ID:GNAL_HUMAN DESCRIPTION: RecName: Full=Guanine nucleotide-binding protein G(olf) subunit alpha; AltName: Full=Adenylate cyclase-stimulating G alpha protein, olfactory type; FUNCTION: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. G(olf) alpha mediates signal transduction within the olfactory neuroepithelium and the basal ganglia. May be involved in some aspect of visual transduction, and in mediating the effect of one or more hormones/neurotransmitters. SUBUNIT: G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site. TISSUE SPECIFICITY: Detected in olfactory neuroepithelium, brain, testis, and to a lower extent in retina, lung alveoli, spleen. Trace amounts where seen in kidney, adrenal gland and liver. Found to be expressed in all the insulinomas examined. SIMILARITY: Belongs to the G-alpha family. G(s) subfamily.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P38405
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
KJ905205 - Synthetic construct Homo sapiens clone ccsbBroadEn_14657 GNAL gene, encodes complete protein. AK295088 - Homo sapiens cDNA FLJ55310 complete cds, highly similar to Guanine nucleotide-binding protein G(olf) subunit alpha. BC050021 - Homo sapiens guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type, mRNA (cDNA clone MGC:51307 IMAGE:5297878), complete cds. CU690628 - Synthetic construct Homo sapiens gateway clone IMAGE:100020896 5' read GNAL mRNA. HQ448004 - Synthetic construct Homo sapiens clone IMAGE:100071374; CCSB010675_02 guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory typ (GNAL) gene, encodes complete protein. AK090868 - Homo sapiens cDNA FLJ33549 fis, clone BRAMY2009013, highly similar to GUANINE NUCLEOTIDE-BINDING PROTEIN G. AK313902 - Homo sapiens cDNA, FLJ94539, Homo sapiens guanine nucleotide binding protein (G protein), alphaactivating activity polypeptide, olfactory type (GNAL), transcriptvariant 2, mRNA. AK290054 - Homo sapiens cDNA FLJ78702 complete cds, highly similar to Homo sapiens guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type (GNAL), transcript variant 2, mRNA. L10665 - Human GTP-binding protein superfamily, G protein alpha-olf subunit (olfactory) mRNA, complete cds. AF493893 - Homo sapiens guanine nucleotide binding protein alpha olf (GNAL) mRNA, complete cds. AK307260 - Homo sapiens cDNA, FLJ97208. AK316141 - Homo sapiens cDNA, FLJ79040 complete cds, highly similar to Guanine nucleotide-binding protein G(olf) subunit alpha. JD137805 - Sequence 118829 from Patent EP1572962. JD383467 - Sequence 364491 from Patent EP1572962. JD252070 - Sequence 233094 from Patent EP1572962. JD121659 - Sequence 102683 from Patent EP1572962. JD137895 - Sequence 118919 from Patent EP1572962. JD250523 - Sequence 231547 from Patent EP1572962. JD271215 - Sequence 252239 from Patent EP1572962. JD205726 - Sequence 186750 from Patent EP1572962. JD314777 - Sequence 295801 from Patent EP1572962. JD288383 - Sequence 269407 from Patent EP1572962. JD249204 - Sequence 230228 from Patent EP1572962. JD178049 - Sequence 159073 from Patent EP1572962. JD271071 - Sequence 252095 from Patent EP1572962. JD396664 - Sequence 377688 from Patent EP1572962. JD403679 - Sequence 384703 from Patent EP1572962. JD380757 - Sequence 361781 from Patent EP1572962. JD066480 - Sequence 47504 from Patent EP1572962. JD180683 - Sequence 161707 from Patent EP1572962. JD059542 - Sequence 40566 from Patent EP1572962. JD408532 - Sequence 389556 from Patent EP1572962. CU687285 - Synthetic construct Homo sapiens gateway clone IMAGE:100022915 3' read MPPE1 mRNA.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein P38405 (Reactome details) participates in the following event(s):
R-HSA-381749 G Protein trimer formation (olfactory) R-HSA-170671 G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex R-HSA-170672 Galpha-olf:GTP binds to adenylate cyclase and activates it R-HSA-170674 Dissociation of the Gi alpha:G olf complex R-HSA-170677 The G alpha-olf:GDP:Adenylate cyclase complex dissociates R-HSA-381750 Olfactory Receptor - G Protein olfactory trimer complex formation R-HSA-170685 Adenylaye cyclase increases the GTPase activity of G alpha-olf R-HSA-170666 Adenylate cyclase increases the GTPase activity of G alpha-olf R-HSA-170686 Adenylate cyclase increases the GTPase activity of Gi alpha R-HSA-170676 Adenylate cyclase converts ATP into cyclic AMP R-HSA-381753 Olfactory Signaling Pathway R-HSA-170670 Adenylate cyclase inhibitory pathway R-HSA-170660 Adenylate cyclase activating pathway R-HSA-418555 G alpha (s) signalling events R-HSA-112040 G-protein mediated events R-HSA-997269 Inhibition of adenylate cyclase pathway R-HSA-388396 GPCR downstream signalling R-HSA-111885 Opioid Signalling R-HSA-991365 Activation of GABAB receptors R-HSA-372790 Signaling by GPCR R-HSA-418594 G alpha (i) signalling events R-HSA-977444 GABA B receptor activation R-HSA-162582 Signal Transduction R-HSA-977443 GABA receptor activation R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112315 Transmission across Chemical Synapses R-HSA-112316 Neuronal System
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
