ID:GNAQ_HUMAN DESCRIPTION: RecName: Full=Guanine nucleotide-binding protein G(q) subunit alpha; AltName: Full=Guanine nucleotide-binding protein alpha-q; FUNCTION: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Regulates B-cell selection and survival and is required to prevent B-cell-dependent autoimmunity. Regulates chemotaxis of BM-derived neutrophils and dendritic cells (in vitro) (By similarity). SUBUNIT: G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site. Binds SLC9A3R1. Forms a complex with PECAM1 and BDKRB2. Interacts with PECAM1. INTERACTION: P10276:RARA; NbExp=4; IntAct=EBI-3909604, EBI-413374; SUBCELLULAR LOCATION: Nucleus (By similarity). Membrane (By similarity). Nucleus membrane (By similarity). Note=Colocalizes with the adrenergic receptors, ADREN1A and ADREN1B, at the nuclear membrane of cardiac myocytes (By similarity). TISSUE SPECIFICITY: Predominantly expressed in ovary, prostate, testis and colon. Down-regulated in the peripheral blood lymphocytes (PBLs) of rheumatoid arthritis patients (at protein level). SIMILARITY: Belongs to the G-alpha family. G(q) subfamily.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P50148
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
U40038 - Human GTP-binding protein alpha q subunit (GNAQ) mRNA, complete cds. BC057777 - Homo sapiens guanine nucleotide binding protein (G protein), q polypeptide, mRNA (cDNA clone MGC:71577 IMAGE:30337698), complete cds. BC067850 - Homo sapiens guanine nucleotide binding protein (G protein), q polypeptide, mRNA (cDNA clone MGC:87452 IMAGE:30348883), complete cds. GQ891431 - Homo sapiens clone HEL-S-152 epididymis secretory sperm binding protein mRNA, complete cds. AK298579 - Homo sapiens cDNA FLJ50831 complete cds, highly similar to Guanine nucleotide-binding protein G(q) subunit alpha. U43083 - Human G alpha-q (Gaq) mRNA, complete cds. BC069520 - Homo sapiens guanine nucleotide binding protein (G protein), q polypeptide, mRNA (cDNA clone MGC:97107 IMAGE:7262332), complete cds. BC075097 - Homo sapiens guanine nucleotide binding protein (G protein), q polypeptide, mRNA (cDNA clone MGC:103986 IMAGE:30915394), complete cds. BC075096 - Homo sapiens guanine nucleotide binding protein (G protein), q polypeptide, mRNA (cDNA clone MGC:104147 IMAGE:30915606), complete cds. AF011496 - Homo sapiens GTP-binding protein alpha q (GQ) mRNA, complete cds. AF329284 - Homo sapiens G alpha q protein mRNA, complete cds. AF493896 - Homo sapiens guanine nucleotide binding protein alpha q (GNAQ) mRNA, complete cds. JN184778 - Homo sapiens guanine nucleotide binding protein (GNAQ) mRNA, complete cds. AM392842 - Synthetic construct Homo sapiens clone IMAGE:100002959 for hypothetical protein (GNAQ gene). AM393393 - Synthetic construct Homo sapiens clone IMAGE:100002961 for hypothetical protein (GNAQ gene). AM393764 - Synthetic construct Homo sapiens clone IMAGE:100002960 for hypothetical protein (GNAQ gene). AB463062 - Synthetic construct DNA, clone: pF1KB8436, Homo sapiens GNAQ gene for guanine nucleotide binding protein (G protein), q polypeptide, without stop codon, in Flexi system. L76256 - Homo sapiens G alpha q mRNA, 5' end of cds. CU691228 - Synthetic construct Homo sapiens gateway clone IMAGE:100020872 5' read GNAQ mRNA. AK055619 - Homo sapiens cDNA FLJ31057 fis, clone HSYRA2000787. BC047048 - Homo sapiens cDNA clone IMAGE:5289004. AJ420425 - Homo sapiens mRNA full length insert cDNA clone EUROIMAGE 1693170. AL832747 - Homo sapiens mRNA; cDNA DKFZp686D0521 (from clone DKFZp686D0521). AB073896 - Homo sapiens primary neuroblastoma cDNA, clone:Nbla03199, full insert sequence. JD044074 - Sequence 25098 from Patent EP1572962. JD516888 - Sequence 497912 from Patent EP1572962. JD444052 - Sequence 425076 from Patent EP1572962. JD049558 - Sequence 30582 from Patent EP1572962. L40629 - Homo sapiens (clones T1, T3, T8) GTP-binding protein alpha subunit (GAQ) mRNA, partial cds. JD535584 - Sequence 516608 from Patent EP1572962.
Biochemical and Signaling Pathways
BioCarta from NCI Cancer Genome Anatomy Project h_At1rPathway - Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling h_calcineurinPathway - Effects of calcineurin in Keratinocyte Differentiation h_Ccr5Pathway - Pertussis toxin-insensitive CCR5 Signaling in Macrophage h_Par1Pathway - Thrombin signaling and protease-activated receptors h_myosinPathway - PKC-catalyzed phosphorylation of inhibitory phosphoprotein of myosin phosphatase h_pyk2Pathway - Links between Pyk2 and Map Kinases h_tubbyPathway - G-Protein Signaling Through Tubby Proteins h_pkcPathway - Activation of PKC through G protein coupled receptor h_CCR3Pathway - CCR3 signaling in Eosinophils h_cxcr4Pathway - CXCR4 Signaling Pathway h_gpcrPathway - Signaling Pathway from G-Protein Families h_vipPathway - Neuropeptides VIP and PACAP inhibit the apoptosis of activated T cells
Reactome (by CSHL, EBI, and GO)
Protein P50148 (Reactome details) participates in the following event(s):
R-HSA-398188 PLC beta is activated by G alpha (q) R-HSA-400586 G alpha (q) binds to Trio family RhoGEFs R-HSA-416358 G alpha (q) inhibits PI3K alpha R-HSA-416510 GRK5 sequesters activated Gq R-HSA-416516 GRK2 sequesters activated Gq R-HSA-418582 G alpha (q) auto-inactivates by hydrolysing GTP to GDP R-HSA-397835 Dissociation of the PAR:Gq complex R-HSA-418576 Dissociation of the P2Y purinoceptor 1:Gq complex R-HSA-428752 Dissociation of the TP:Gq complex R-HSA-749452 The Ligand:GPCR:Gq complex dissociates R-HSA-750993 Inactive G alpha (q) reassociates with G beta:gamma R-HSA-400023 Gq alpha activates Phospholipase C beta R-HSA-400027 Gq alpha:G beta:G gamma dissociates to Gq alpha:GTP and G beta:G gamma R-HSA-396996 Thrombin-activated PAR binds G-protein Gq R-HSA-418581 Activated P2Y purinoceptor 1 binds G-protein Gq R-HSA-428749 Activated TP receptor binds G-proten Gq R-HSA-749448 Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq R-HSA-399995 Muscarinic Acetylcholine Receptor M3 activates Gq R-HSA-416530 GPR40:fatty acid activates Gq R-HSA-114558 Gq activation by PAR R-HSA-418579 Gq activation by P2Y purinoceptor 1 R-HSA-428750 Gq activation by TP receptor R-HSA-379048 Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 R-HSA-114688 PLC-beta hydrolyses PIP2 to DAG and IP3 R-HSA-399998 Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate R-HSA-416476 G alpha (q) signalling events R-HSA-456926 Thrombin signalling through proteinase activated receptors (PARs) R-HSA-418592 ADP signalling through P2Y purinoceptor 1 R-HSA-428930 Thromboxane signalling through TP receptor R-HSA-399997 Acetylcholine regulates insulin secretion R-HSA-434316 Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-388396 GPCR downstream signalling R-HSA-76002 Platelet activation, signaling and aggregation R-HSA-392518 Signal amplification R-HSA-422356 Regulation of insulin secretion R-HSA-400451 Free fatty acids regulate insulin secretion R-HSA-372790 Signaling by GPCR R-HSA-109582 Hemostasis R-HSA-163685 Energy Metabolism R-HSA-162582 Signal Transduction R-HSA-1430728 Metabolism
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
