ID:GNAZ_HUMAN DESCRIPTION: RecName: Full=Guanine nucleotide-binding protein G(z) subunit alpha; AltName: Full=G(x) alpha chain; AltName: Full=Gz-alpha; FUNCTION: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. SUBUNIT: G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site. SUBCELLULAR LOCATION: Membrane; Lipid-anchor. SIMILARITY: Belongs to the G-alpha family. G(i/o/t/z) subfamily.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P19086
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
BC037333 - Homo sapiens guanine nucleotide binding protein (G protein), alpha z polypeptide, mRNA (cDNA clone MGC:43258 IMAGE:5264642), complete cds. BC026342 - Homo sapiens guanine nucleotide binding protein (G protein), alpha z polypeptide, mRNA (cDNA clone MGC:26547 IMAGE:4814858), complete cds. AK312519 - Homo sapiens cDNA, FLJ92884, Homo sapiens guanine nucleotide binding protein (G protein), alphaz polypeptide (GNAZ), mRNA. AK293653 - Homo sapiens cDNA FLJ51798 complete cds, highly similar to Guanine nucleotide-binding protein G(z) subunit alpha. BC078163 - Homo sapiens guanine nucleotide binding protein (G protein), alpha z polypeptide, mRNA (cDNA clone MGC:88028 IMAGE:6180193), complete cds. CR456495 - Homo sapiens GNAZ full length open reading frame (ORF) cDNA clone (cDNA clone C22ORF:pGEM.GNAZ.V4). J03260 - Human transducin alpha-subunit (GNAZ) mRNA, complete cds. CU013380 - Homo sapiens GNAZ, mRNA (cDNA clone IMAGE:100000255), complete cds, without stop codon, in Gateway system. DQ892386 - Synthetic construct clone IMAGE:100005016; FLH185839.01X; RZPDo839F08148D guanine nucleotide binding protein (G protein), alpha z polypeptide (GNAZ) gene, encodes complete protein. EU176512 - Synthetic construct Homo sapiens clone IMAGE:100011490; FLH185838.01L; RZPDo839F05253D guanine nucleotide binding protein (G protein), alpha z polypeptide (GNAZ) gene, encodes complete protein. BC096828 - Homo sapiens guanine nucleotide binding protein (G protein), alpha z polypeptide, mRNA (cDNA clone MGC:111695 IMAGE:6519151), complete cds. CU013092 - Homo sapiens GNAZ, mRNA (cDNA clone IMAGE:100000351), complete cds, with stop codon, in Gateway system. AB463061 - Synthetic construct DNA, clone: pF1KB4667, Homo sapiens GNAZ gene for guanine nucleotide binding protein (G protein), alpha z polypeptide, without stop codon, in Flexi system. CU687322 - Synthetic construct Homo sapiens gateway clone IMAGE:100022954 5' read GNAZ mRNA. KJ896900 - Synthetic construct Homo sapiens clone ccsbBroadEn_06294 GNAZ gene, encodes complete protein. KJ896901 - Synthetic construct Homo sapiens clone ccsbBroadEn_06295 GNAZ gene, encodes complete protein. KJ896902 - Synthetic construct Homo sapiens clone ccsbBroadEn_06296 GNAZ gene, encodes complete protein. AF493899 - Homo sapiens guanine nucleotide binding protein alpha z (GNAZ) mRNA, complete cds. AK309397 - Homo sapiens cDNA, FLJ99438. JD541578 - Sequence 522602 from Patent EP1572962. JD419463 - Sequence 400487 from Patent EP1572962. JD261036 - Sequence 242060 from Patent EP1572962. JD432307 - Sequence 413331 from Patent EP1572962. JD151992 - Sequence 133016 from Patent EP1572962. JD323464 - Sequence 304488 from Patent EP1572962. JD477294 - Sequence 458318 from Patent EP1572962. JD193746 - Sequence 174770 from Patent EP1572962. JD450788 - Sequence 431812 from Patent EP1572962. JD097278 - Sequence 78302 from Patent EP1572962. JD069415 - Sequence 50439 from Patent EP1572962. JD409181 - Sequence 390205 from Patent EP1572962. JD503569 - Sequence 484593 from Patent EP1572962. JD357851 - Sequence 338875 from Patent EP1572962. JD494070 - Sequence 475094 from Patent EP1572962. JD353619 - Sequence 334643 from Patent EP1572962. JD110027 - Sequence 91051 from Patent EP1572962. JD528934 - Sequence 509958 from Patent EP1572962. JD245352 - Sequence 226376 from Patent EP1572962. JD083840 - Sequence 64864 from Patent EP1572962. JD458859 - Sequence 439883 from Patent EP1572962. JD443348 - Sequence 424372 from Patent EP1572962. JD394209 - Sequence 375233 from Patent EP1572962. JD162323 - Sequence 143347 from Patent EP1572962. JD229680 - Sequence 210704 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein P19086 (Reactome details) participates in the following event(s):
R-HSA-392064 G alpha (z) inhibits adenylate cyclase R-HSA-392133 G alpha (z) auto-inactivates by hydrolysing GTP to GDP R-HSA-8982703 PKC binds active G alpha (z) R-HSA-751024 The Ligand:GPCR:Gz complex dissociates R-HSA-750988 Inactive G alpha (z) reassociates with G beta:gamma R-HSA-8850560 G-protein alpha releases G-protein heterotrimer from PDCL R-HSA-8982709 G-alpha(z):PKC dissociates to give phosphorylated G alpha (z) R-HSA-751040 PKC phosphorylates G alpha (z) R-HSA-749446 Liganded Gz-activating GPCRs bind inactive heterotrimeric G-protein Gz R-HSA-167433 G-protein beta-gamma subunits rebind the alpha-GDP subunit R-HSA-112037 Inactivation of PLC beta R-HSA-167415 G-protein alpha subunit is inactivated R-HSA-111870 Activation of PLC beta-1/4 R-HSA-112271 The receptor:G-protein complex dissociates R-HSA-167429 The receptor:G-protein complex binds GTP R-HSA-749453 Liganded Gz-activating GPCR acts as a GEF for Gz R-HSA-167408 The high affinity receptor complex binds to G-protein R-HSA-167419 The receptor:G-protein complex releases GDP R-HSA-111879 PIP2 hydrolysis R-HSA-418597 G alpha (z) signalling events R-HSA-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-388396 GPCR downstream signalling R-HSA-202040 G-protein activation R-HSA-112043 PLC beta mediated events R-HSA-390466 Chaperonin-mediated protein folding R-HSA-372790 Signaling by GPCR R-HSA-111885 Opioid Signalling R-HSA-112040 G-protein mediated events R-HSA-391251 Protein folding R-HSA-162582 Signal Transduction R-HSA-418594 G alpha (i) signalling events R-HSA-392499 Metabolism of proteins
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
