ID:GNL3_HUMAN DESCRIPTION: RecName: Full=Guanine nucleotide-binding protein-like 3; AltName: Full=E2-induced gene 3 protein; AltName: Full=Novel nucleolar protein 47; Short=NNP47; AltName: Full=Nucleolar GTP-binding protein 3; AltName: Full=Nucleostemin; FUNCTION: May be required to maintain the proliferative capacity of stem cells. Stabilizes MDM2 by preventing its ubiquitination, and hence proteasomal degradation (By similarity). SUBUNIT: Interacts with MDM2; this interaction stabilizes MDM2. Interaction with MDM2 occurs in the nucleoplasm and is triggered by a nucleolar release mechanism, such as mitosis-induced nucleolar disassembly (By similarity). Indirectly interacts with TP53, via MDM2-binding (By similarity). INTERACTION: Q00987:MDM2; NbExp=3; IntAct=EBI-641642, EBI-389668; Q15172:PPP2R5A; NbExp=3; IntAct=EBI-641642, EBI-641666; P40763:STAT3; NbExp=2; IntAct=EBI-641642, EBI-518675; SUBCELLULAR LOCATION: Nucleus (By similarity). Nucleus, nucleolus (By similarity). Note=Shuttles between the nucleus and nucleolus (By similarity). TISSUE SPECIFICITY: Increased levels in lung tissue in cancer patients. DOMAIN: The basic domain (B) allows nucleolar localization in the absence of GTP. The intermediate domain (I) inhibits nucleolar localization by the B domain and is required for exit from the nucleolus. Exit from the nucleolus to the nucleoplasm requires both the I and the acidic (A) domains, and may be triggered by GTP hydrolysis (By similarity). DOMAIN: In contrast to other GTP-binding proteins, this family is characterized by a circular permutation of the GTPase motifs described by a G4-G1-G3 pattern. SIMILARITY: Belongs to the MMR1/HSR1 GTP-binding protein family. SIMILARITY: Contains 1 G (guanine nucleotide-binding) domain. SEQUENCE CAUTION: Sequence=AAF09482.1; Type=Frameshift; Positions=516;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9BVP2
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0008283 cell proliferation GO:0017145 stem cell division GO:0019827 stem cell population maintenance GO:0032206 positive regulation of telomere maintenance GO:0033235 positive regulation of protein sumoylation GO:0042127 regulation of cell proliferation GO:0042254 ribosome biogenesis GO:1902895 positive regulation of pri-miRNA transcription from RNA polymerase II promoter GO:1904816 positive regulation of protein localization to chromosome, telomeric region
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
