Human Gene GNMT (ENST00000372808.4_4) from GENCODE V47lift37
  Description: glycine N-methyltransferase, transcript variant 3 (from RefSeq NR_134899.2)
Gencode Transcript: ENST00000372808.4_4
Gencode Gene: ENSG00000124713.6_7
Transcript (Including UTRs)
   Position: hg19 chr6:42,928,492-42,931,618 Size: 3,127 Total Exon Count: 6 Strand: +
Coding Region
   Position: hg19 chr6:42,928,506-42,931,444 Size: 2,939 Coding Exon Count: 6 

Page IndexSequence and LinksPrimersMalaCardsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureOther SpeciesmRNA DescriptionsOther Names
Model InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr6:42,928,492-42,931,618)mRNA (may differ from genome)Protein (295 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsHGNC
MalacardsMGIOMIMPubMedUniProtKBWikipedia
BioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: GNMT
Diseases sorted by gene-association score: glycine n-methyltransferase deficiency* (1703), hypermethioninemia* (300), hepatocellular carcinoma (2)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 216.05 RPKM in Pancreas
Total median expression: 343.02 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
3' UTR -62.50174-0.359 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details Gene Details  
Gene SorterGene Sorter Gene Sorter  
 RGDEnsembl   
      
      

-  Descriptions from all associated GenBank mRNAs
  X62250 - H.sapiens mRNA for liver glycine methyltransferase.
BC032627 - Homo sapiens glycine N-methyltransferase, mRNA (cDNA clone MGC:45044 IMAGE:5229272), complete cds.
AF101477 - Homo sapiens glycine N-methyltransferase (GNMT) mRNA, complete cds.
FJ224320 - Homo sapiens epididymis secretory sperm binding protein Li 182mP (HEL-S-182mP) mRNA, complete cds.
AB590322 - Synthetic construct DNA, clone: pFN21AE1438, Homo sapiens GNMT gene for glycine N-methyltransferase, without stop codon, in Flexi system.
KU178603 - Homo sapiens glycine N-methyltransferase isoform 1 (GNMT) mRNA, partial cds.
KU178604 - Homo sapiens glycine N-methyltransferase isoform 3 (GNMT) mRNA, partial cds, alternatively spliced.
KU178605 - Homo sapiens glycine N-methyltransferase isoform 4 (GNMT) mRNA, complete cds, alternatively spliced.
DQ890819 - Synthetic construct clone IMAGE:100003449; FLH166204.01X; RZPDo839D1286D glycine N-methyltransferase (GNMT) gene, encodes complete protein.
DQ893974 - Synthetic construct Homo sapiens clone IMAGE:100008434; FLH166200.01L; RZPDo839D1285D glycine N-methyltransferase (GNMT) gene, encodes complete protein.
KJ893614 - Synthetic construct Homo sapiens clone ccsbBroadEn_03008 GNMT gene, encodes complete protein.
KR710867 - Synthetic construct Homo sapiens clone CCSBHm_00017726 GNMT (GNMT) mRNA, encodes complete protein.
KR710868 - Synthetic construct Homo sapiens clone CCSBHm_00017727 GNMT (GNMT) mRNA, encodes complete protein.
KR710869 - Synthetic construct Homo sapiens clone CCSBHm_00017728 GNMT (GNMT) mRNA, encodes complete protein.
JD527788 - Sequence 508812 from Patent EP1572962.
JD105189 - Sequence 86213 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000372808.1, ENST00000372808.2, ENST00000372808.3, GNMT , HEL-S-182mP , NR_134899, uc318kfq.1, uc318kfq.2, V9HW60, V9HW60_HUMAN
UCSC ID: ENST00000372808.4_4
RefSeq Accession: NM_018960.6

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.