ID:GOLP3_HUMAN DESCRIPTION: RecName: Full=Golgi phosphoprotein 3; AltName: Full=Coat protein GPP34; AltName: Full=Mitochondrial DNA absence factor; Short=MIDAS; FUNCTION: Mediates the cis and medial Golgi localization of mannosyltransferases through direct binding of their cytosolic domains. Involved in modulation of mTOR signaling. Involved in the regulation of mitochondrial lipids, leading to increase of mitochondrial mass. Potential oncogene. SUBUNIT: Homodimer. Interacts with VPS35. INTERACTION: Q92614:MYO18A; NbExp=4; IntAct=EBI-2465479, EBI-949059; P12520:vpr (xeno); NbExp=3; IntAct=EBI-2465479, EBI-6164519; SUBCELLULAR LOCATION: Cell membrane (By similarity). Endosome (By similarity). Cytoplasm. Golgi apparatus, Golgi stack membrane; Peripheral membrane protein; Cytoplasmic side. Mitochondrion intermembrane space. Note=Phosphatidylinositol 4-phosphate (PtdIns4P) binding is essential for Golgi localization. TISSUE SPECIFICITY: Detected in muscle fibers of patients with mitochondrial diseases; not detected in normal muscle fibers. INDUCTION: Activated by depletion of mitochondrial DNA. PTM: Phosphorylated (By similarity). MISCELLANEOUS: Modulates sensitivity to rapamycin. Tumors expressing this protein are more sensitive to rapamycin in vivo. SIMILARITY: Belongs to the GOLPH3/VPS74 family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9H4A6
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006890 retrograde vesicle-mediated transport, Golgi to ER GO:0007030 Golgi organization GO:0008283 cell proliferation GO:0009101 glycoprotein biosynthetic process GO:0009306 protein secretion GO:0010467 gene expression GO:0010821 regulation of mitochondrion organization GO:0015031 protein transport GO:0016477 cell migration GO:0030032 lamellipodium assembly GO:0032008 positive regulation of TOR signaling GO:0043001 Golgi to plasma membrane protein transport GO:0043066 negative regulation of apoptotic process GO:0045053 protein retention in Golgi apparatus GO:0048194 Golgi vesicle budding GO:0050714 positive regulation of protein secretion GO:0050901 leukocyte tethering or rolling GO:0060352 cell adhesion molecule production GO:0090161 Golgi ribbon formation GO:0090164 asymmetric Golgi ribbon formation
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
