Human Gene GOSR1 (ENST00000451249.7_6) from GENCODE V47lift37

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Description: golgi SNAP receptor complex member 1, transcript variant 2 (from RefSeq NM_001007025.2)
Gencode Transcript: ENST00000451249.7_6
Gencode Gene: ENSG00000108587.16_11
Transcript (Including UTRs)
Position: hg19 chr17:28,804,426-28,854,610 Size: 50,185 Total Exon Count: 9 Strand: +
Coding Region
Position: hg19 chr17:28,804,452-28,849,396 Size: 44,945 Coding Exon Count: 9

Page Index	Sequence and Links	UniProtKB Comments	Primers	MalaCards	CTD
Gene Alleles	RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species
GO Annotations	mRNA Descriptions	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr17:28,804,426-28,854,610)			mRNA (may differ from genome)		Protein (248 aa)
Gene Sorter	Genome Browser	Other Species FASTA	Gene interactions	Table Schema	AlphaFold
BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards	HGNC
Human Cortex Gene Expression	Malacards	MGI	OMIM	PubMed	UniProtKB
Wikipedia	BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: E9PCW1_HUMAN DESCRIPTION: RecName: Full=Golgi SNAP receptor complex member 1; FUNCTION: Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide- sensitive factor) attachment protein receptor (By similarity). SUBUNIT: Component of several multiprotein Golgi SNARE complexes (By similarity). SUBCELLULAR LOCATION: Golgi apparatus membrane (By similarity). SIMILARITY: Belongs to the GOSR1 family. CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

MalaCards Disease Associations


	MalaCards Gene Search: GOSR1 Diseases sorted by gene-association score: chromosome 17q11.2 deletion syndrome, 1.4-mb (2)

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene C006780 bisphenol A C111118 2',3,3',4',5-pentachloro-4-hydroxybiphenyl C023514 2,6-dinitrotoluene D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide C547126 AZM551248 D000082 Acetaminophen D000643 Ammonium Chloride D001564 Benzo(a)pyrene D002110 Caffeine D002994 Clofibrate more ... click here to view the complete list

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 6.95 RPKM in Cells - EBV-transformed lymphocytes Total median expression: 228.98 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-5.00	26	-0.192	Picture	PostScript	Text
3' UTR	-1721.67	5214	-0.330	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR023601 - Golgi_SNAP_su1

Pfam Domains:
PF12352 - Snare region anchored in the vesicle membrane C-terminus

SCOP Domains:
81923 - Double Clp-N motif
58038 - SNARE fusion complex

ModBase Predicted Comparative 3D Structure on E9PCW1


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	Genome Browser	Genome Browser
Gene Details	Gene Details		Gene Details	Gene Details	Gene Details
Gene Sorter	Gene Sorter		Gene Sorter	Gene Sorter	Gene Sorter
	RGD	Ensembl		WormBase	SGD
				Protein Sequence	Protein Sequence
				Alignment	Alignment

Gene Ontology (GO) Annotations with Structured Vocabulary


	Biological Process: GO:0006888 ER to Golgi vesicle-mediated transport GO:0015031 protein transport GO:0016192 vesicle-mediated transport Cellular Component: GO:0000139 Golgi membrane GO:0005794 Golgi apparatus GO:0005801 cis-Golgi network GO:0016020 membrane GO:0016021 integral component of membrane

Descriptions from all associated GenBank mRNAs


	AK291381 - Homo sapiens cDNA FLJ77138 complete cds, highly similar to Homo sapiens golgi SNAP receptor complex member 1 (GOSR1), transcript variant 1, mRNA. AK000606 - Homo sapiens cDNA FLJ20599 fis, clone KAT07688, highly similar to AF047438 Homo sapiens GOS28/P28 protein mRNA. AK298714 - Homo sapiens cDNA FLJ58038 complete cds, highly similar to Golgi SNAP receptor complex member 1. AF047438 - Homo sapiens GOS28/P28 protein mRNA, complete cds. AF073926 - Homo sapiens cis-Golgi SNARE p28 (GS28) mRNA, complete cds. BC040471 - Homo sapiens golgi SNAP receptor complex member 1, mRNA (cDNA clone MGC:32615 IMAGE:4697067), complete cds. KC119452 - Homo sapiens cell-line SeAx androgen-induced 1/Golgi SNAP receptor complex member 1 variant 2 fusion protein (AIG1/GOSR1 fusion) mRNA, partial cds. BC012620 - Homo sapiens golgi SNAP receptor complex member 1, mRNA (cDNA clone MGC:13657 IMAGE:4250494), complete cds. KJ904628 - Synthetic construct Homo sapiens clone ccsbBroadEn_14022 GOSR1 gene, encodes complete protein. AK128816 - Homo sapiens cDNA FLJ46071 fis, clone TESOP2009247. KC119451 - Homo sapiens cell-line SeAx androgen-induced 1/Golgi SNAP receptor complex member 1 variant 1 fusion protein (AIG1/GOSR1 fusion) mRNA, partial cds. DQ578909 - Homo sapiens piRNA piR-47021, complete sequence. JD550456 - Sequence 531480 from Patent EP1572962. JD162035 - Sequence 143059 from Patent EP1572962. JD267127 - Sequence 248151 from Patent EP1572962. JD319128 - Sequence 300152 from Patent EP1572962. JD088967 - Sequence 69991 from Patent EP1572962. DQ579541 - Homo sapiens piRNA piR-47653, complete sequence. JD375681 - Sequence 356705 from Patent EP1572962. JD309952 - Sequence 290976 from Patent EP1572962. JD352968 - Sequence 333992 from Patent EP1572962. JD526283 - Sequence 507307 from Patent EP1572962. JD256763 - Sequence 237787 from Patent EP1572962. JD152665 - Sequence 133689 from Patent EP1572962. JD159742 - Sequence 140766 from Patent EP1572962. JD213013 - Sequence 194037 from Patent EP1572962. JD213012 - Sequence 194036 from Patent EP1572962. DQ583196 - Homo sapiens piRNA piR-50308, complete sequence. JD321888 - Sequence 302912 from Patent EP1572962. JD134506 - Sequence 115530 from Patent EP1572962. JD416230 - Sequence 397254 from Patent EP1572962. DQ575471 - Homo sapiens piRNA piR-43583, complete sequence. BC017035 - Homo sapiens cDNA clone IMAGE:3847788, partial cds. JD271373 - Sequence 252397 from Patent EP1572962. JD412581 - Sequence 393605 from Patent EP1572962. DQ599726 - Homo sapiens piRNA piR-37792, complete sequence. DQ574987 - Homo sapiens piRNA piR-43099, complete sequence. JD311576 - Sequence 292600 from Patent EP1572962. DQ575296 - Homo sapiens piRNA piR-43408, complete sequence. DQ577286 - Homo sapiens piRNA piR-45398, complete sequence. DQ601422 - Homo sapiens piRNA piR-39488, complete sequence. DQ588541 - Homo sapiens piRNA piR-55653, complete sequence. DQ571050 - Homo sapiens piRNA piR-31162, complete sequence. JD265711 - Sequence 246735 from Patent EP1572962. BC040072 - Homo sapiens golgi SNAP receptor complex member 1, mRNA (cDNA clone IMAGE:5001859). DQ578550 - Homo sapiens piRNA piR-46662, complete sequence. DQ591787 - Homo sapiens piRNA piR-58899, complete sequence. DQ591044 - Homo sapiens piRNA piR-58156, complete sequence. DQ586319 - Homo sapiens piRNA piR-53431, complete sequence. DQ586320 - Homo sapiens piRNA piR-53432, complete sequence. JD549343 - Sequence 530367 from Patent EP1572962. JD180503 - Sequence 161527 from Patent EP1572962. JD046598 - Sequence 27622 from Patent EP1572962. JD174076 - Sequence 155100 from Patent EP1572962. JD048092 - Sequence 29116 from Patent EP1572962. AK074298 - Homo sapiens cDNA FLJ23718 fis, clone HEP13678. AL049346 - Homo sapiens mRNA; cDNA DKFZp566B213 (from clone DKFZp566B213). JD274818 - Sequence 255842 from Patent EP1572962.

Other Names for This Gene


	Alternate Gene Symbols: E9PCW1, E9PCW1_HUMAN, ENST00000451249.1, ENST00000451249.2, ENST00000451249.3, ENST00000451249.4, ENST00000451249.5, ENST00000451249.6, GOSR1 , NM_001007025, uc320sqg.1, uc320sqg.2 UCSC ID: ENST00000451249.7_6 RefSeq Accession: NM_001007025.2 Protein: E9PCW1

Gene Model Information


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Methods, Credits, and Use Restrictions


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