ID:GOSR2_HUMAN DESCRIPTION: RecName: Full=Golgi SNAP receptor complex member 2; AltName: Full=27 kDa Golgi SNARE protein; AltName: Full=Membrin; FUNCTION: Involved in transport of proteins from the cis/medial- Golgi to the trans-Golgi network. SUBUNIT: Identified in a unique SNARE complex composed of the Golgi SNAREs GOSR1, STX5 and YKT6 (By similarity). SUBCELLULAR LOCATION: Golgi apparatus membrane; Single-pass type IV membrane protein (Potential). DISEASE: Defects in GOSR2 are the cause of progressive myoclonic epilepsy type 6 (EPM6) [MIM:614018]. A neurologic disorder characterized by onset of ataxia in the first years of life, followed by action myoclonus and seizures later in childhood, and loss of independent ambulation in the second decade. Cognition is not usually affected, although mild memory difficulties may occur in the third decade. SIMILARITY: Belongs to the GOSR2 family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
Pfam Domains: PF12352 - Snare region anchored in the vesicle membrane C-terminus
ModBase Predicted Comparative 3D Structure on O14653
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006623 protein targeting to vacuole GO:0006888 ER to Golgi vesicle-mediated transport GO:0006891 intra-Golgi vesicle-mediated transport GO:0006896 Golgi to vacuole transport GO:0015031 protein transport GO:0016192 vesicle-mediated transport GO:0036498 IRE1-mediated unfolded protein response GO:0042147 retrograde transport, endosome to Golgi GO:0048208 COPII vesicle coating GO:0048280 vesicle fusion with Golgi apparatus
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
