Human Gene GP5 (ENST00000692618.1_3) from GENCODE V47lift37
  Description: glycoprotein V platelet (from RefSeq NM_004488.2)
Gencode Transcript: ENST00000692618.1_3
Gencode Gene: ENSG00000178732.6_8
Transcript (Including UTRs)
   Position: hg19 chr3:194,115,550-194,119,995 Size: 4,446 Total Exon Count: 2 Strand: -
Coding Region
   Position: hg19 chr3:194,117,329-194,119,011 Size: 1,683 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr3:194,115,550-194,119,995)mRNA (may differ from genome)Protein (560 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsHGNC
MalacardsMGIOMIMPubMedReactomeUniProtKB
WikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: GPV_HUMAN
DESCRIPTION: RecName: Full=Platelet glycoprotein V; Short=GPV; AltName: Full=Glycoprotein 5; AltName: CD_antigen=CD42d; Flags: Precursor;
FUNCTION: The GPIb-V-IX complex functions as the vWF receptor and mediates vWF-dependent platelet adhesion to blood vessels. The adhesion of platelets to injured vascular surfaces in the arterial circulation is a critical initiating event in hemostasis.
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
TISSUE SPECIFICITY: Platelets and megakaryocytes.
PTM: The N-terminus is blocked.
SIMILARITY: Contains 13 LRR (leucine-rich) repeats.
SIMILARITY: Contains 1 LRRCT domain.
SIMILARITY: Contains 1 LRRNT domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: GP5
Diseases sorted by gene-association score: ureter inverted papilloma (6), ureter urothelial papilloma (6), bernard-soulier syndrome, type c (5), cervical adenosarcoma (3), blood platelet disease (3), vulva cancer (3), gray platelet syndrome (3), inverted follicular keratosis (2), cervix uteri carcinoma in situ (2), cervical carcinosarcoma (2), female reproductive organ cancer (2), cervical clear cell adenocarcinoma (1), tonsil cancer (1), reproductive organ cancer (1), chronic laryngitis (1), tonsil squamous cell carcinoma (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -6.4031-0.206 Picture PostScript Text
3' UTR -568.801779-0.320 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000483 - Cys-rich_flank_reg_C
IPR001611 - Leu-rich_rpt
IPR003591 - Leu-rich_rpt_typical-subtyp
IPR000372 - LRR-contain_N

Pfam Domains:
PF00560 - Leucine Rich Repeat
PF01463 - Leucine rich repeat C-terminal domain
PF13306 - BspA type Leucine rich repeat region (6 copies)
PF13855 - Leucine rich repeat

SCOP Domains:
52047 - RNI-like
52058 - L domain-like
52075 - Outer arm dynein light chain 1

ModBase Predicted Comparative 3D Structure on P40197
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
  Ensembl   
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding

Biological Process:
GO:0007155 cell adhesion
GO:0007409 axonogenesis
GO:0007596 blood coagulation
GO:0007597 blood coagulation, intrinsic pathway
GO:0007599 hemostasis
GO:0030168 platelet activation

Cellular Component:
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0070062 extracellular exosome


-  Descriptions from all associated GenBank mRNAs
  L11238 - Homo sapiens platelet membrane glycoprotein V mRNA, complete cds.
BC152810 - Synthetic construct Homo sapiens clone IMAGE:100016057, MGC:184129 glycoprotein V (platelet) (GP5) mRNA, encodes complete protein.
AB527338 - Synthetic construct DNA, clone: pF1KE0070, Homo sapiens GP5 gene for glycoprotein V, without stop codon, in Flexi system.
JD449801 - Sequence 430825 from Patent EP1572962.
JD538109 - Sequence 519133 from Patent EP1572962.
JD163663 - Sequence 144687 from Patent EP1572962.
JD344503 - Sequence 325527 from Patent EP1572962.
JD349654 - Sequence 330678 from Patent EP1572962.
JD290250 - Sequence 271274 from Patent EP1572962.
JD201972 - Sequence 182996 from Patent EP1572962.
JD424260 - Sequence 405284 from Patent EP1572962.
JD465607 - Sequence 446631 from Patent EP1572962.
JD499939 - Sequence 480963 from Patent EP1572962.
JD269205 - Sequence 250229 from Patent EP1572962.
JD255389 - Sequence 236413 from Patent EP1572962.
JD166356 - Sequence 147380 from Patent EP1572962.
JD195352 - Sequence 176376 from Patent EP1572962.
JD042284 - Sequence 23308 from Patent EP1572962.
JD197161 - Sequence 178185 from Patent EP1572962.
JD553319 - Sequence 534343 from Patent EP1572962.
JD296647 - Sequence 277671 from Patent EP1572962.
JD255509 - Sequence 236533 from Patent EP1572962.
JD151228 - Sequence 132252 from Patent EP1572962.
JD360667 - Sequence 341691 from Patent EP1572962.
JD455883 - Sequence 436907 from Patent EP1572962.
JD225422 - Sequence 206446 from Patent EP1572962.
JD500824 - Sequence 481848 from Patent EP1572962.
JD409804 - Sequence 390828 from Patent EP1572962.
JD337050 - Sequence 318074 from Patent EP1572962.
JD196435 - Sequence 177459 from Patent EP1572962.
JD476387 - Sequence 457411 from Patent EP1572962.
JD276124 - Sequence 257148 from Patent EP1572962.
JD162669 - Sequence 143693 from Patent EP1572962.
JD153484 - Sequence 134508 from Patent EP1572962.
JD198548 - Sequence 179572 from Patent EP1572962.
JD338375 - Sequence 319399 from Patent EP1572962.
JD388957 - Sequence 369981 from Patent EP1572962.
JD293448 - Sequence 274472 from Patent EP1572962.
JD457527 - Sequence 438551 from Patent EP1572962.
JD457528 - Sequence 438552 from Patent EP1572962.
JD523082 - Sequence 504106 from Patent EP1572962.
JD497280 - Sequence 478304 from Patent EP1572962.
JD145983 - Sequence 127007 from Patent EP1572962.
JD405628 - Sequence 386652 from Patent EP1572962.
JD457526 - Sequence 438550 from Patent EP1572962.
JD162668 - Sequence 143692 from Patent EP1572962.
JD050685 - Sequence 31709 from Patent EP1572962.
JD491078 - Sequence 472102 from Patent EP1572962.
JD061267 - Sequence 42291 from Patent EP1572962.
JD236172 - Sequence 217196 from Patent EP1572962.
JD398475 - Sequence 379499 from Patent EP1572962.
JD297697 - Sequence 278721 from Patent EP1572962.
JD402571 - Sequence 383595 from Patent EP1572962.
JD290320 - Sequence 271344 from Patent EP1572962.
JD524543 - Sequence 505567 from Patent EP1572962.
JD254337 - Sequence 235361 from Patent EP1572962.
JD127064 - Sequence 108088 from Patent EP1572962.
JD465220 - Sequence 446244 from Patent EP1572962.
JD429359 - Sequence 410383 from Patent EP1572962.
JD311375 - Sequence 292399 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein P40197 (Reactome details) participates in the following event(s):

R-HSA-114670 GPIb-IX-V binds to vWF:Collagen complex
R-HSA-158145 factor XI + platelet glycoprotein (GP) Ib:IX:V complex -> factor XI:platelet glycoprotein (GP) Ib:IX:V complex
R-HSA-158300 factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (XIIa catalyst)
R-HSA-158419 factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (thrombin catalyst)
R-HSA-429529 Thrombin binding to GP1b:IX:V
R-HSA-430076 GP1b-IX-V binds 14-3-3-zeta
R-HSA-430096 GP1b-IX-V binds filamin
R-HSA-430073 GPIb-IX-V binding to 14-3-3 zeta is reduced by shear stress
R-HSA-158333 factor IX -> factor IXa + factor IX activation peptide (factor XIa catalyst)
R-HSA-443402 GP1b-IX-V:13-3-3-zeta complexes with p85 PI3K
R-HSA-75892 Platelet Adhesion to exposed collagen
R-HSA-140837 Intrinsic Pathway of Fibrin Clot Formation
R-HSA-76009 Platelet Aggregation (Plug Formation)
R-HSA-430116 GP1b-IX-V activation signalling
R-HSA-109582 Hemostasis
R-HSA-140877 Formation of Fibrin Clot (Clotting Cascade)
R-HSA-76002 Platelet activation, signaling and aggregation

-  Other Names for This Gene
  Alternate Gene Symbols: D1MER9, GPV_HUMAN, NM_004488, P40197, uc330xmp.1, uc330xmp.2
UCSC ID: ENST00000692618.1_3
RefSeq Accession: NM_004488.2
Protein: P40197 (aka GPV_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.