ID:GPVI_HUMAN DESCRIPTION: RecName: Full=Platelet glycoprotein VI; Short=GPVI; AltName: Full=Glycoprotein 6; Flags: Precursor; FUNCTION: Collagen receptor involved in collagen-induced platelet adhesion and activation. Plays a key role in platelet procoagulant activity and subsequent thrombin and fibrin formation. This procoagulant function may contribute to arterial and venous thrombus formation. The signaling pathway involves the FcR gamma- chain, the Src kinases (likely Fyn/Lyn), the adapter protein LAT and leads to the activation of phospholipase C gamma2. SUBUNIT: Associated with Fc receptor gamma chain. The GPVI- FcRgamma complex is associated with the Src kinase family Fyn and Lyn. INTERACTION: P07948:LYN; NbExp=2; IntAct=EBI-515278, EBI-79452; SUBCELLULAR LOCATION: Isoform 1: Cell membrane; Single-pass membrane protein. SUBCELLULAR LOCATION: Isoform 2: Cell membrane; Single-pass membrane protein. TISSUE SPECIFICITY: Megakaryocytes and platelets. PTM: N-linked glycosylation at Asn-92 is not required for the cell surface expression, but contributes to maximal adhesion to type I collagen, collagen-related peptide (CRP), and, to a lesser extent, to the snake venom C-type lectin convulxin (CVX). DISEASE: Defects in GP6 are the cause of bleeding disorder platelet-type 11 (BDPLT11) [MIM:614201]. BDPLT11 is a mild to moderate bleeding disorder caused by defective platelet activation and aggregation in response to collagen. SIMILARITY: Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9HCN6
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
