ID:GPC3_HUMAN DESCRIPTION: RecName: Full=Glypican-3; AltName: Full=GTR2-2; AltName: Full=Intestinal protein OCI-5; AltName: Full=MXR7; Contains: RecName: Full=Secreted glypican-3; Flags: Precursor; FUNCTION: Cell surface proteoglycan that bears heparan sulfate. Inhibits the dipeptidyl peptidase activity of DPP4. May be involved in the suppression/modulation of growth in the predominantly mesodermal tissues and organs. May play a role in the modulation of IGF2 interactions with its receptor and thereby modulate its function. May regulate growth and tumor predisposition. SUBUNIT: Interacts with DPP4. SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side (By similarity). SUBCELLULAR LOCATION: Secreted glypican-3: Secreted, extracellular space (By similarity). TISSUE SPECIFICITY: Highly expressed in lung, liver and kidney. DISEASE: Defects in GPC3 are the cause of Simpson-Golabi-Behmel syndrome type 1 (SGBS1) [MIM:312870]; also known as Simpson dysmorphia syndrome (SDYS). SGBS is a condition characterized by pre- and postnatal overgrowth (gigantism) with visceral and skeletal anomalies. SIMILARITY: Belongs to the glypican family. WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/GPC3ID156.html"; WEB RESOURCE: Name=GeneReviews; URL="http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/GPC3";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P51654
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Protein P51654 (Reactome details) participates in the following event(s):
R-HSA-1878002 XYLTs transfer Xyl to core protein R-HSA-1889955 B3GATs transfer GlcA to tetrasaccharide linker R-HSA-1889978 B3GALT6 transfers Gal to the tetrasaccharide linker R-HSA-2022919 EXT1:EXT2 transfers GlcNAc to the terminal GlcA residue R-HSA-1889981 B4GALT7 transfers Gal group to xylosyl-unit of the tetrasaccharide linker R-HSA-2022851 EXT1:EXT2 transfer GlcNAc to the heparan chain R-HSA-2022856 EXT1:EXT2 transfers GlcNAc to heparan R-HSA-2022887 NDST1-4 N-deacetylates GlcNAc residues in heparan R-HSA-2076392 EXT1:EXT2 transfers GlcA to heparan R-HSA-2022860 NDST1-4 can sulfate a glucosamine residue in heparan to form heparan sulfate (HS) R-HSA-2076419 HS6STs sulfate GlcN at C6 in heparan sulfate/heparin R-HSA-2076371 GLCE epimerises more GlcA to IdoA as sulfate content rises R-HSA-2076508 HS2ST1 sulfates IdoA at C2 in heparan sulfate R-HSA-2024100 GLCE epimerises GlcA to IdoA R-HSA-2076383 HS3ST1 sulfates GlcN at C3 in heparan sulfate R-HSA-2076611 HS3STs sulfate GlcN at C3 in heparan sulfate R-HSA-1678694 Heparanase 2 (HPSE2) cleaves heparan sulfate from its proteoglycan (plasma membrane) R-HSA-1667005 Heparanase (HPSE) cleaves heparan sulfate from its proteoglycan (lysosome) R-HSA-2423785 CR:atREs binds apoE and HSPG R-HSA-2429643 NREH hydrolyses atREs (HSPG:apoE) to atROL and FAs R-HSA-8952289 FAM20C phosphorylates FAM20C substrates R-HSA-2404131 LRPs transport extracellular CR:atREs:HSPG:apoE to cytosol R-HSA-1971475 A tetrasaccharide linker sequence is required for GAG synthesis R-HSA-3560801 Defective B3GAT3 causes JDSSDHD R-HSA-2022928 HS-GAG biosynthesis R-HSA-3656253 Defective EXT1 causes exostoses 1, TRPS2 and CHDS R-HSA-3656237 Defective EXT2 causes exostoses 2 R-HSA-3560783 Defective B4GALT7 causes EDS, progeroid type R-HSA-4420332 Defective B3GALT6 causes EDSP2 and SEMDJL1 R-HSA-2024096 HS-GAG degradation R-HSA-1638091 Heparan sulfate/heparin (HS-GAG) metabolism R-HSA-1793185 Chondroitin sulfate/dermatan sulfate metabolism R-HSA-3560782 Diseases associated with glycosaminoglycan metabolism R-HSA-975634 Retinoid metabolism and transport R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-8957275 Post-translational protein phosphorylation R-HSA-1630316 Glycosaminoglycan metabolism R-HSA-3781865 Diseases of glycosylation R-HSA-2187338 Visual phototransduction R-HSA-6806667 Metabolism of fat-soluble vitamins R-HSA-392499 Metabolism of proteins R-HSA-597592 Post-translational protein modification R-HSA-71387 Metabolism of carbohydrates R-HSA-1643685 Disease R-HSA-418594 G alpha (i) signalling events R-HSA-196854 Metabolism of vitamins and cofactors R-HSA-1430728 Metabolism R-HSA-388396 GPCR downstream signalling R-HSA-372790 Signaling by GPCR R-HSA-162582 Signal Transduction
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Common Gene Haplotype Alleles 
