ID:GPC4_HUMAN DESCRIPTION: RecName: Full=Glypican-4; AltName: Full=K-glypican; Contains: RecName: Full=Secreted glypican-4; Flags: Precursor; FUNCTION: Cell surface proteoglycan that bears heparan sulfate. May be involved in the development of kidney tubules and of the central nervous system (By similarity). SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side (By similarity). SUBCELLULAR LOCATION: Secreted glypican-4: Secreted, extracellular space (By similarity). SIMILARITY: Belongs to the glypican family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O75487
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
AF030186 - Homo sapiens glypican-4 (GPC4) mRNA, complete cds. AY358507 - Homo sapiens clone DNA56436 glypican 4 (UNQ474) mRNA, complete cds. BC017166 - Homo sapiens glypican 4, mRNA (cDNA clone MGC:9107 IMAGE:3922774), complete cds. AK304207 - Homo sapiens cDNA FLJ51457 complete cds, highly similar to Glypican-4 precursor. AF064826 - Homo sapiens glypican 4 (GPC4) mRNA, complete cds. AY052833 - Homo sapiens glypican-4 (GPC4) mRNA, complete cds. AK312605 - Homo sapiens cDNA, FLJ92982, Homo sapiens glypican 4 (GPC4), mRNA. DQ891809 - Synthetic construct clone IMAGE:100004439; FLH180143.01X; RZPDo839G05132D glypican 4 (GPC4) gene, encodes complete protein. KJ891159 - Synthetic construct Homo sapiens clone ccsbBroadEn_00553 GPC4 gene, encodes complete protein. DQ894992 - Synthetic construct Homo sapiens clone IMAGE:100009452; FLH180140.01L; RZPDo839G05131D glypican 4 (GPC4) gene, encodes complete protein. AB528412 - Synthetic construct DNA, clone: pF1KB3124, Homo sapiens GPC4 gene for glypican 4, without stop codon, in Flexi system. CU677845 - Synthetic construct Homo sapiens gateway clone IMAGE:100019859 5' read GPC4 mRNA. AF088063 - Homo sapiens full length insert cDNA clone ZD74F11. JD486860 - Sequence 467884 from Patent EP1572962. JD410188 - Sequence 391212 from Patent EP1572962. JD173787 - Sequence 154811 from Patent EP1572962. JD047834 - Sequence 28858 from Patent EP1572962. JD220638 - Sequence 201662 from Patent EP1572962. JD089104 - Sequence 70128 from Patent EP1572962. JD089648 - Sequence 70672 from Patent EP1572962. JD306250 - Sequence 287274 from Patent EP1572962. JD510173 - Sequence 491197 from Patent EP1572962. JD345903 - Sequence 326927 from Patent EP1572962. JD041776 - Sequence 22800 from Patent EP1572962. JD145826 - Sequence 126850 from Patent EP1572962. JD062066 - Sequence 43090 from Patent EP1572962. JD493794 - Sequence 474818 from Patent EP1572962. JD230998 - Sequence 212022 from Patent EP1572962. JD508589 - Sequence 489613 from Patent EP1572962. JD453705 - Sequence 434729 from Patent EP1572962. JD236911 - Sequence 217935 from Patent EP1572962. JD051986 - Sequence 33010 from Patent EP1572962. JD173864 - Sequence 154888 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein O75487 (Reactome details) participates in the following event(s):
R-HSA-1878002 XYLTs transfer Xyl to core protein R-HSA-1889955 B3GATs transfer GlcA to tetrasaccharide linker R-HSA-1889978 B3GALT6 transfers Gal to the tetrasaccharide linker R-HSA-1889981 B4GALT7 transfers Gal group to xylosyl-unit of the tetrasaccharide linker R-HSA-2022919 EXT1:EXT2 transfers GlcNAc to the terminal GlcA residue R-HSA-2076508 HS2ST1 sulfates IdoA at C2 in heparan sulfate R-HSA-2024100 GLCE epimerises GlcA to IdoA R-HSA-2076371 GLCE epimerises more GlcA to IdoA as sulfate content rises R-HSA-2076383 HS3ST1 sulfates GlcN at C3 in heparan sulfate R-HSA-2076611 HS3STs sulfate GlcN at C3 in heparan sulfate R-HSA-2022860 NDST1-4 can sulfate a glucosamine residue in heparan to form heparan sulfate (HS) R-HSA-2022887 NDST1-4 N-deacetylates GlcNAc residues in heparan R-HSA-2022856 EXT1:EXT2 transfers GlcNAc to heparan R-HSA-2076419 HS6STs sulfate GlcN at C6 in heparan sulfate/heparin R-HSA-2076392 EXT1:EXT2 transfers GlcA to heparan R-HSA-2022851 EXT1:EXT2 transfer GlcNAc to the heparan chain R-HSA-1678694 Heparanase 2 (HPSE2) cleaves heparan sulfate from its proteoglycan (plasma membrane) R-HSA-1667005 Heparanase (HPSE) cleaves heparan sulfate from its proteoglycan (lysosome) R-HSA-2423785 CR:atREs binds apoE and HSPG R-HSA-2429643 NREH hydrolyses atREs (HSPG:apoE) to atROL and FAs R-HSA-2404131 LRPs transport extracellular CR:atREs:HSPG:apoE to cytosol R-HSA-1971475 A tetrasaccharide linker sequence is required for GAG synthesis R-HSA-3560801 Defective B3GAT3 causes JDSSDHD R-HSA-4420332 Defective B3GALT6 causes EDSP2 and SEMDJL1 R-HSA-3560783 Defective B4GALT7 causes EDS, progeroid type R-HSA-2022928 HS-GAG biosynthesis R-HSA-3656253 Defective EXT1 causes exostoses 1, TRPS2 and CHDS R-HSA-3656237 Defective EXT2 causes exostoses 2 R-HSA-2024096 HS-GAG degradation R-HSA-1638091 Heparan sulfate/heparin (HS-GAG) metabolism R-HSA-1793185 Chondroitin sulfate/dermatan sulfate metabolism R-HSA-3560782 Diseases associated with glycosaminoglycan metabolism R-HSA-975634 Retinoid metabolism and transport R-HSA-1630316 Glycosaminoglycan metabolism R-HSA-3781865 Diseases of glycosylation R-HSA-2187338 Visual phototransduction R-HSA-6806667 Metabolism of fat-soluble vitamins R-HSA-71387 Metabolism of carbohydrates R-HSA-1643685 Disease R-HSA-418594 G alpha (i) signalling events R-HSA-196854 Metabolism of vitamins and cofactors R-HSA-1430728 Metabolism R-HSA-388396 GPCR downstream signalling R-HSA-372790 Signaling by GPCR R-HSA-162582 Signal Transduction
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
