Human Gene GPN1 (ENST00000264718.7_7) from GENCODE V47lift37
Description: Small GTPase required for proper nuclear import of RNA polymerase II (RNAPII) (PubMed:20855544, PubMed:21768307). May act at an RNAP assembly step prior to nuclear import (PubMed:21768307). Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding proteins, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation (PubMed:17643375). May be involved in nuclear localization of XPA (PubMed:11058119). (from UniProt Q9HCN4) Gencode Transcript: ENST00000264718.7_7 Gencode Gene: ENSG00000198522.14_15 Transcript (Including UTRs) Position: hg19 chr2:27,851,863-27,874,375 Size: 22,513 Total Exon Count: 14 Strand: + Coding Region Position: hg19 chr2:27,851,884-27,873,067 Size: 21,184 Coding Exon Count: 14
ID:GPN1_HUMAN DESCRIPTION: RecName: Full=GPN-loop GTPase 1; AltName: Full=MBD2-interacting protein; Short=MBDin; AltName: Full=XPA-binding protein 1; FUNCTION: Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding protein, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation. May be involved in nuclear localization of XPA. SUBUNIT: Tightly associated with the RNA polymerase II complex. Interacts with XPA. SUBCELLULAR LOCATION: Cytoplasm. TISSUE SPECIFICITY: Expressed ubiquitously. SIMILARITY: Belongs to the GPN-loop GTPase family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9HCN4
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
