Human Gene GPR101 (ENST00000651716.2_6) from GENCODE V47lift37
  Description: G protein-coupled receptor 101 (from RefSeq NM_054021.2)
Gencode Transcript: ENST00000651716.2_6
Gencode Gene: ENSG00000165370.3_10
Transcript (Including UTRs)
   Position: hg19 chrX:136,106,088-136,116,154 Size: 10,067 Total Exon Count: 2 Strand: -
Coding Region
   Position: hg19 chrX:136,112,307-136,113,833 Size: 1,527 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesGeneReviewsModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chrX:136,106,088-136,116,154)mRNA (may differ from genome)Protein (508 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCHuman Cortex Gene ExpressionMalacardsMGIOMIMPubMed
UniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: GP101_HUMAN
DESCRIPTION: RecName: Full=Probable G-protein coupled receptor 101;
FUNCTION: Orphan receptor.
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
SEQUENCE CAUTION: Sequence=BAC06152.1; Type=Erroneous initiation;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: GPR101
Diseases sorted by gene-association score: pituitary adenoma, growth hormone-secreting 2* (1230), chromosome xq26.3 duplication syndrome* (525), acromegaly* (29), pituitary adenoma, growth hormone-secreting (18), gigantism (16), pituitary adenoma (10), carney complex variant (4), adenoma (4)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
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+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -145.80286-0.510 Picture PostScript Text
3' UTR -1574.406219-0.253 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000276 - 7TM_GPCR_Rhodpsn
IPR017452 - GPCR_Rhodpsn_supfam

Pfam Domains:
PF00001 - 7 transmembrane receptor (rhodopsin family)
PF10323 - Serpentine type 7TM GPCR chemoreceptor Srv

SCOP Domains:
81321 - Family A G protein-coupled receptor-like

ModBase Predicted Comparative 3D Structure on Q96P66
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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 RGDEnsembl   
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004871 signal transducer activity
GO:0004930 G-protein coupled receptor activity
GO:0004935 adrenergic receptor activity

Biological Process:
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007267 cell-cell signaling
GO:0071880 adenylate cyclase-activating adrenergic receptor signaling pathway

Cellular Component:
GO:0005622 intracellular
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0043235 receptor complex


-  Descriptions from all associated GenBank mRNAs
  BC069439 - Homo sapiens G protein-coupled receptor 101, mRNA (cDNA clone MGC:97123 IMAGE:7262356), complete cds.
KJ899706 - Synthetic construct Homo sapiens clone ccsbBroadEn_09100 GPR101 gene, encodes complete protein.
CU686814 - Synthetic construct Homo sapiens gateway clone IMAGE:100022686 5' read GPR101 mRNA.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000651716.1, GP101_HUMAN, NM_054021, Q5JSM8, Q8NG93, Q96P66, uc328tii.1, uc328tii.2
UCSC ID: ENST00000651716.2_6
RefSeq Accession: NM_054021.2
Protein: Q96P66 (aka GP101_HUMAN or G101_HUMAN)

-  GeneReviews for This Gene
  GeneReviews article(s) related to gene GPR101:
x-ag (X-Linked Acrogigantism)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.