Human Gene ADGRF1 (ENST00000283297.5_6) from GENCODE V47lift37
  Description: Orphan receptor. (from UniProt Q5T601)
Gencode Transcript: ENST00000283297.5_6
Gencode Gene: ENSG00000153292.16_11
Transcript (Including UTRs)
   Position: hg19 chr6:46,967,959-46,986,235 Size: 18,277 Total Exon Count: 9 Strand: -
Coding Region
   Position: hg19 chr6:46,967,959-46,986,235 Size: 18,277 Coding Exon Count: 9 

Page IndexSequence and LinksUniProtKB CommentsPrimersGene AllelesRNA-Seq Expression
Protein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther NamesModel Information
Methods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr6:46,967,959-46,986,235)mRNA (may differ from genome)Protein (713 aa)
Gene SorterGenome BrowserOther Species FASTATable SchemaAlphaFoldBioGPS
EnsemblExonPrimerGeneCardsMGIPubMedUniProtKB
Wikipedia

-  Comments and Description Text from UniProtKB
  ID: GP110_HUMAN
DESCRIPTION: RecName: Full=Probable G-protein coupled receptor 110; AltName: Full=G-protein coupled receptor KPG_012; AltName: Full=G-protein coupled receptor PGR19; Flags: Precursor;
FUNCTION: Orphan receptor.
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
SIMILARITY: Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.
SIMILARITY: Contains 1 GPS domain.
SIMILARITY: Contains 1 SEA domain.
SEQUENCE CAUTION: Sequence=BAB70874.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAB70874.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact; Sequence=BAC45260.1; Type=Erroneous gene model prediction; Sequence=CAI13873.1; Type=Erroneous gene model prediction;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 10.67 RPKM in Kidney - Cortex
Total median expression: 33.97 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR017981 - GPCR_2-like
IPR008078 - GPCR_2_Ig-hepta_rcpt
IPR000832 - GPCR_2_secretin-like
IPR000203 - GPS_dom
IPR000082 - SEA

Pfam Domains:
PF00002 - 7 transmembrane receptor (Secretin family)
PF01825 - GPCR proteolysis site, GPS, motif

ModBase Predicted Comparative 3D Structure on Q5T601
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004871 signal transducer activity
GO:0004888 transmembrane signaling receptor activity
GO:0004930 G-protein coupled receptor activity

Biological Process:
GO:0007165 signal transduction
GO:0007166 cell surface receptor signaling pathway
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway
GO:0007416 synapse assembly
GO:0007613 memory
GO:0031175 neuron projection development
GO:0032793 positive regulation of CREB transcription factor activity

Cellular Component:
GO:0005576 extracellular region
GO:0005622 intracellular
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  CR627234 - Homo sapiens mRNA; cDNA DKFZp781C1512 (from clone DKFZp781C1512).
BC144253 - Homo sapiens cDNA clone IMAGE:9052773, with apparent retained intron.
BC160016 - Synthetic construct Homo sapiens clone IMAGE:100063952, MGC:193131 G protein-coupled receptor 110 (GPR110) mRNA, encodes complete protein.
AY140952 - Homo sapiens G-protein coupled receptor GPR110 (GPR110) mRNA, complete cds.
AB045123 - Homo sapiens mRNA for KPG_012 protein, complete cds.
AY255595 - Homo sapiens G protein-coupled receptor PGR19 mRNA, partial cds.
BC029358 - Homo sapiens G protein-coupled receptor 110, mRNA (cDNA clone IMAGE:4612868), partial cds.
AK095348 - Homo sapiens cDNA FLJ38029 fis, clone CTONG2013284.

-  Other Names for This Gene
  Alternate Gene Symbols: ADGRF1 , AGRF1_HUMAN, AY140952, ENST00000283297.1, ENST00000283297.2, ENST00000283297.3, ENST00000283297.4, GPR110, PGR19, Q5KU15, Q5T5Z9, Q5T600, Q5T601, Q86SM1, Q8IXE3, Q8IZF8, Q96DQ1, Q9H615, uc317kci.1
UCSC ID: ENST00000283297.5_6
RefSeq Accession: NM_153840.4
Protein: Q5T601 (aka GP110_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.