Human Gene ADGRG4 (ENST00000370652.5_4) from GENCODE V47lift37
  Description: Orphan receptor. (from UniProt Q8IZF6)
Gencode Transcript: ENST00000370652.5_4
Gencode Gene: ENSG00000156920.11_8
Transcript (Including UTRs)
   Position: hg19 chrX:135,387,012-135,499,047 Size: 112,036 Total Exon Count: 24 Strand: +
Coding Region
   Position: hg19 chrX:135,390,937-135,498,650 Size: 107,714 Coding Exon Count: 23 

Page IndexSequence and LinksUniProtKB CommentsPrimersGene AllelesRNA-Seq Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther Names
Model InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chrX:135,387,012-135,499,047)mRNA (may differ from genome)Protein (3080 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaAlphaFold
BioGPSEnsemblExonPrimerGeneCardsMGIPubMed
UniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: GP112_HUMAN
DESCRIPTION: RecName: Full=Probable G-protein coupled receptor 112; Flags: Precursor;
FUNCTION: Orphan receptor.
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: Detected in fetal retina. Highly expressed in normal enterochromaffin cells and in neuroendocrine carcinoma. Detected in normal liver; highly expressed in primary liver carcinoma.
SIMILARITY: Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.
SIMILARITY: Contains 1 GPS domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 1.04 RPKM in Fallopian Tube
Total median expression: 2.61 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -57.30180-0.318 Picture PostScript Text
3' UTR -57.10397-0.144 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR008985 - ConA-like_lec_gl_sf
IPR013320 - ConA-like_subgrp
IPR017981 - GPCR_2-like
IPR000832 - GPCR_2_secretin-like
IPR017983 - GPCR_2_secretin-like_CS
IPR000203 - GPS_dom
IPR001759 - Pentaxin

Pfam Domains:
PF00002 - 7 transmembrane receptor (Secretin family)
PF00354 - Pentaxin family
PF01825 - GPCR proteolysis site, GPS, motif

SCOP Domains:
49899 - Concanavalin A-like lectins/glucanases
81321 - Family A G protein-coupled receptor-like

ModBase Predicted Comparative 3D Structure on Q8IZF6
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details  Gene Details  
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004871 signal transducer activity
GO:0004888 transmembrane signaling receptor activity
GO:0004930 G-protein coupled receptor activity

Biological Process:
GO:0007165 signal transduction
GO:0007166 cell surface receptor signaling pathway
GO:0007186 G-protein coupled receptor signaling pathway

Cellular Component:
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  AY882585 - Homo sapiens G protein-coupled receptor 112 (GPR112) mRNA, complete cds.
CR936801 - Homo sapiens mRNA; cDNA DKFZp781E1948 (from clone DKFZp781E1948).
BC156126 - Synthetic construct Homo sapiens clone IMAGE:100062412, MGC:190508 G protein-coupled receptor 112 (GPR112) mRNA, encodes complete protein.
AB590036 - Synthetic construct DNA, clone: pF1KE1597, Homo sapiens GPR112 gene for G protein-coupled receptor 112, without stop codon, in Flexi system.
AY140954 - Homo sapiens G-protein coupled receptor GPR112 (GPR112) mRNA, complete cds.
AY255581 - Homo sapiens G protein-coupled receptor GPR112 mRNA, partial cds.

-  Other Names for This Gene
  Alternate Gene Symbols: A2A2J1, A2A2J2, AGRG4_HUMAN, AY882585, ENST00000370652.1, ENST00000370652.2, ENST00000370652.3, ENST00000370652.4, GPR112, Q5EGP2, Q86SM6, Q8IZF6, uc318int.1
UCSC ID: ENST00000370652.5_4
RefSeq Accession: NM_153834.4
Protein: Q8IZF6 (aka GP112_HUMAN or G112_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.