Human Gene ADGRF3 (ENST00000311519.5_10) from GENCODE V47lift37
  Description: adhesion G protein-coupled receptor F3, transcript variant 1 (from RefSeq NM_001145168.1)
Gencode Transcript: ENST00000311519.5_10
Gencode Gene: ENSG00000173567.16_18
Transcript (Including UTRs)
   Position: hg19 chr2:26,532,812-26,541,917 Size: 9,106 Total Exon Count: 13 Strand: -
Coding Region
   Position: hg19 chr2:26,532,812-26,541,917 Size: 9,106 Coding Exon Count: 13 

Page IndexSequence and LinksUniProtKB CommentsPrimersGene AllelesRNA-Seq Expression
Protein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther NamesModel Information
Methods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr2:26,532,812-26,541,917)mRNA (may differ from genome)Protein (1079 aa)
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-  Comments and Description Text from UniProtKB
  ID: GP113_HUMAN
DESCRIPTION: RecName: Full=Probable G-protein coupled receptor 113; AltName: Full=G-protein coupled receptor PGR23; Flags: Precursor;
FUNCTION: Orphan receptor.
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
SIMILARITY: Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.
SIMILARITY: Contains 1 GPS domain.
SEQUENCE CAUTION: Sequence=BAB89332.1; Type=Erroneous initiation; Sequence=BAC45265.1; Type=Erroneous gene model prediction;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 0.73 RPKM in Testis
Total median expression: 7.88 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR022624 - DUF3497
IPR017981 - GPCR_2-like
IPR001879 - GPCR_2_extracellular_dom
IPR000832 - GPCR_2_secretin-like
IPR017983 - GPCR_2_secretin-like_CS
IPR000203 - GPS_dom

Pfam Domains:
PF00002 - 7 transmembrane receptor (Secretin family)
PF01825 - GPCR proteolysis site, GPS, motif

SCOP Domains:
48726 - Immunoglobulin
81321 - Family A G protein-coupled receptor-like
111418 - Hormone receptor domain

ModBase Predicted Comparative 3D Structure on Q8IZF5
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004871 signal transducer activity
GO:0004888 transmembrane signaling receptor activity
GO:0004930 G-protein coupled receptor activity

Biological Process:
GO:0007165 signal transduction
GO:0007166 cell surface receptor signaling pathway
GO:0007186 G-protein coupled receptor signaling pathway

Cellular Component:
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  BC043211 - Homo sapiens cDNA clone IMAGE:5295143, containing frame-shift errors.
AK122995 - Homo sapiens cDNA FLJ16767 fis, clone BRAWH3015260, highly similar to Probable G-protein coupled receptor 113 precursor.
AY358172 - Homo sapiens clone DNA203528 GPR113 (UNQ9196) mRNA, complete cds.
AY358214 - Homo sapiens clone DNA173909 GPR113 (UNQ9196) precursor RNA, partial cds.
AK293887 - Homo sapiens cDNA FLJ57026 complete cds, highly similar to Probable G-protein coupled receptor 113 precursor.
AY140955 - Homo sapiens G-protein coupled receptor GPR113 (GPR113) mRNA, complete cds.
BC148416 - Synthetic construct Homo sapiens clone IMAGE:100015421, MGC:183029 G protein-coupled receptor 113 (GPR113) mRNA, encodes complete protein.
BC152988 - Synthetic construct Homo sapiens clone IMAGE:100016228, MGC:184240 G protein-coupled receptor 113 (GPR113) mRNA, encodes complete protein.
AB527153 - Synthetic construct DNA, clone: pF1KB7350, Homo sapiens GPR113 gene for G protein-coupled receptor 113, without stop codon, in Flexi system.
AY255611 - Homo sapiens G protein-coupled receptor PGR23 mRNA, partial cds.

-  Other Names for This Gene
  Alternate Gene Symbols: AGRF3_HUMAN, B4DF15, E9PEV1, ENST00000311519.1, ENST00000311519.2, ENST00000311519.3, ENST00000311519.4, GPR113, NM_001145168, PGR23, Q53TA5, Q6UXT7, Q6UXX3, Q86SL7, Q8IXD8, Q8IZF5, Q8TDT3, uc317pad.1, uc317pad.2, UNQ9196/PRO34000
UCSC ID: ENST00000311519.5_10
RefSeq Accession: NM_001145168.1
Protein: Q8IZF5 (aka GP113_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.