Human Gene ADGRA1 (ENST00000392606.2_2) from GENCODE V47lift37
  Description: adhesion G protein-coupled receptor A1, transcript variant 2 (from RefSeq NM_001291085.2)
Gencode Transcript: ENST00000392606.2_2
Gencode Gene: ENSG00000197177.16_9
Transcript (Including UTRs)
   Position: hg19 chr10:134,915,750-134,944,932 Size: 29,183 Total Exon Count: 4 Strand: +
Coding Region
   Position: hg19 chr10:134,916,237-134,943,015 Size: 26,779 Coding Exon Count: 3 

Page IndexSequence and LinksUniProtKB CommentsPrimersGene AllelesRNA-Seq Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther Names
Model InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr10:134,915,750-134,944,932)mRNA (may differ from genome)Protein (463 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsMGI
OMIMPubMedUniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: GP123_HUMAN
DESCRIPTION: RecName: Full=Probable G-protein coupled receptor 123;
FUNCTION: Orphan receptor.
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
SIMILARITY: Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.
SEQUENCE CAUTION: Sequence=BAB47457.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 12.05 RPKM in Brain - Cortex
Total median expression: 67.74 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -39.40129-0.305 Picture PostScript Text
3' UTR -722.801917-0.377 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR017981 - GPCR_2-like
IPR000832 - GPCR_2_secretin-like
IPR017983 - GPCR_2_secretin-like_CS

ModBase Predicted Comparative 3D Structure on Q86SQ6
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004871 signal transducer activity
GO:0004888 transmembrane signaling receptor activity
GO:0004930 G-protein coupled receptor activity

Biological Process:
GO:0007165 signal transduction
GO:0007166 cell surface receptor signaling pathway
GO:0007186 G-protein coupled receptor signaling pathway

Cellular Component:
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  AB527154 - Synthetic construct DNA, clone: pF1KB7324, Homo sapiens GPR123 gene for G protein-coupled receptor 123, without stop codon, in Flexi system.
AY181241 - Homo sapiens G protein-coupled receptor 123 (GPR123) mRNA, complete cds.
BC146320 - Synthetic construct Homo sapiens clone IMAGE:100015186, MGC:180240 G protein-coupled receptor 123 (GPR123) mRNA, encodes complete protein.
AK124728 - Homo sapiens cDNA FLJ42738 fis, clone BRAWH2016221, weakly similar to T-CELL RECEPTOR BETA CHAIN ANA 11.
EF536972 - Homo sapiens G protein-coupled receptor 123 (GPR123) mRNA, complete cds.
AB058731 - Homo sapiens KIAA1828 mRNA for KIAA1828 protein.
AY255564 - Homo sapiens G protein-coupled receptor KIAA1828 protein mRNA, partial cds.
AK090982 - Homo sapiens cDNA FLJ33663 fis, clone BRAMY2027114.
AX746717 - Sequence 242 from Patent EP1308459.
AK094675 - Homo sapiens cDNA FLJ37356 fis, clone BRAMY2022984.
BC044247 - Homo sapiens, clone IMAGE:5764216, mRNA.
JD394475 - Sequence 375499 from Patent EP1572962.
JD105045 - Sequence 86069 from Patent EP1572962.
JD207042 - Sequence 188066 from Patent EP1572962.
AK098741 - Homo sapiens cDNA FLJ25875 fis, clone CBR02521.

-  Other Names for This Gene
  Alternate Gene Symbols: A5HL16, A6NG50, ADGRA1 , AGRA1_HUMAN, ENST00000392606.1, GPR123, KIAA1828, NM_001291085, Q5T234, Q86SN7, Q86SQ6, Q96JJ9, uc318vfs.1
UCSC ID: ENST00000392606.2_2
RefSeq Accession: NM_001291085.2
Protein: Q86SQ6 (aka GP123_HUMAN or G123_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.