ID:GP126_HUMAN DESCRIPTION: RecName: Full=G-protein coupled receptor 126; AltName: Full=Developmentally regulated G-protein-coupled receptor; AltName: Full=Vascular inducible G protein-coupled receptor; Flags: Precursor; FUNCTION: Orphan receptor. May be required for normal differentiation of promyelinating Schwann cells and for normal myelination of axons. Signals probably through G-proteins to transiently elevate cAMP levels (By similarity). SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Note=Detected on the cell surface of activated but not resting umbilical vein. TISSUE SPECIFICITY: Expressed in placenta and to a lower extent in pancreas and liver. Detected in aortic endothelial cells but not in skin microvascular endothelial cells. INDUCTION: Up-regulated by bacterial lipopolysaccharides (LPS) and thrombin, but not by other inflammatory stimuli in primary umbilical veins. PTM: Proteolytically cleaved into 2 conserved sites: one in the GPS domain (S1 site) and the other in the middle of the extracellular domain (S2 site). The proteolytic cleavage at S1 site generates an extracellular subunit and a seven-transmembrane subunit. Furin is involved in the cleavage of the S2 site generating a soluble fragment. Processing at the GPS domain occurred independent of and probably prior to the cleavage at the S2 site. POLYMORPHISM: Genetic variations in GPR126 influences stature as a quantitative trait (STQTL) [MIM:606255]. Adult height is an easily observable and highly heritable complex continuous trait. Because of this, it is a model trait for studying genetic influence on quantitative traits. SIMILARITY: Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily. SIMILARITY: Contains 1 CUB domain. SIMILARITY: Contains 1 GPS domain. SIMILARITY: Contains 1 pentaxin domain. SEQUENCE CAUTION: Sequence=AAO13250.1; Type=Miscellaneous discrepancy; Note=Sequencing errors; Sequence=BAB55406.1; Type=Erroneous initiation; Sequence=BAC11393.1; Type=Erroneous initiation; Sequence=CAE45930.1; Type=Erroneous initiation; Sequence=CAI20053.1; Type=Erroneous gene model prediction;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
SCOP Domains: 81296 - E set domains 49854 - Spermadhesin, CUB domain 49899 - Concanavalin A-like lectins/glucanases 81321 - Family A G protein-coupled receptor-like
ModBase Predicted Comparative 3D Structure on Q86SQ4
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
