Human Gene ADGRD1 (ENST00000261654.10_11) from GENCODE V47lift37

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Description: adhesion G protein-coupled receptor D1, transcript variant 1 (from RefSeq NM_198827.5)
Gencode Transcript: ENST00000261654.10_11
Gencode Gene: ENSG00000111452.13_16
Transcript (Including UTRs)
Position: hg19 chr12:131,438,452-131,626,014 Size: 187,563 Total Exon Count: 25 Strand: +
Coding Region
Position: hg19 chr12:131,439,011-131,623,808 Size: 184,798 Coding Exon Count: 25

Page Index	Sequence and Links	UniProtKB Comments	Primers	MalaCards	Gene Alleles
RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species	GO Annotations
mRNA Descriptions	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr12:131,438,452-131,626,014)			mRNA (may differ from genome)		Protein (874 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Table Schema	AlphaFold
BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards	Malacards
MGI	OMIM	PubMed	UniProtKB	Wikipedia	BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: GP133_HUMAN DESCRIPTION: RecName: Full=Probable G-protein coupled receptor 133; AltName: Full=G-protein coupled receptor PGR25; Flags: Precursor; FUNCTION: Orphan receptor. SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. SIMILARITY: Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily. SIMILARITY: Contains 1 GPS domain.

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

MalaCards Disease Associations


	MalaCards Gene Search: ADGRD1 Diseases sorted by gene-association score: glioblastoma (4)

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 21.10 RPKM in Heart - Atrial Appendage Total median expression: 259.25 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-182.30	559	-0.326	Picture	PostScript	Text
3' UTR	-872.40	2206	-0.395	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR008985 - ConA-like_lec_gl_sf
IPR013320 - ConA-like_subgrp
IPR017981 - GPCR_2-like
IPR000832 - GPCR_2_secretin-like
IPR017983 - GPCR_2_secretin-like_CS
IPR000203 - GPS_dom

Pfam Domains:
PF00002 - 7 transmembrane receptor (Secretin family)
PF01825 - GPCR proteolysis site, GPS, motif
PF05462 - Slime mold cyclic AMP receptor
PF13385 - Concanavalin A-like lectin/glucanases superfamily

SCOP Domains:
49899 - Concanavalin A-like lectins/glucanases
50965 - Galactose oxidase, central domain
81321 - Family A G protein-coupled receptor-like

ModBase Predicted Comparative 3D Structure on Q6QNK2


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details
Gene Sorter	Gene Sorter
	RGD

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0004871 signal transducer activity GO:0004888 transmembrane signaling receptor activity GO:0004930 G-protein coupled receptor activity Biological Process: GO:0007165 signal transduction GO:0007166 cell surface receptor signaling pathway GO:0007186 G-protein coupled receptor signaling pathway GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway Cellular Component: GO:0005622 intracellular GO:0005886 plasma membrane GO:0016020 membrane GO:0016021 integral component of membrane

Descriptions from all associated GenBank mRNAs


	KJ906476 - Synthetic construct Homo sapiens clone ccsbBroadEn_16146 GPR133 gene, encodes complete protein. BX649116 - Homo sapiens mRNA; cDNA DKFZp686M24109 (from clone DKFZp686M24109). AY532280 - Homo sapiens G protein coupled receptor 133 (GPR133) mRNA, complete cds. EU523118 - Homo sapiens G protein coupled receptor 133 variant 2 (GPR133) mRNA, complete cds, alternatively spliced. BC112307 - Homo sapiens G protein-coupled receptor 133, mRNA (cDNA clone MGC:138512 IMAGE:8327775), complete cds. BC112309 - Homo sapiens G protein-coupled receptor 133, mRNA (cDNA clone MGC:138514 IMAGE:8327777), complete cds. BC143775 - Homo sapiens G protein-coupled receptor 133, mRNA (cDNA clone MGC:177306 IMAGE:9052289), complete cds. AK131538 - Homo sapiens cDNA FLJ16770 fis, clone BRAWH3028645, weakly similar to Rattus norvegicus CL1BA protein (CL1BA). AY255587 - Homo sapiens G protein-coupled receptor PGR25 mRNA, partial cds. AL162032 - Homo sapiens mRNA; cDNA DKFZp434B1272 (from clone DKFZp434B1272); partial cds. AY278561 - Homo sapiens G-protein coupled receptor GPR133 (GPR133) mRNA, complete cds. BC047951 - Homo sapiens G protein-coupled receptor 133, mRNA (cDNA clone IMAGE:5766895), partial cds. JD404139 - Sequence 385163 from Patent EP1572962. JD416967 - Sequence 397991 from Patent EP1572962. JD547794 - Sequence 528818 from Patent EP1572962. JD283048 - Sequence 264072 from Patent EP1572962. JD218341 - Sequence 199365 from Patent EP1572962. JD464473 - Sequence 445497 from Patent EP1572962. JD523228 - Sequence 504252 from Patent EP1572962. JD396812 - Sequence 377836 from Patent EP1572962. JD466831 - Sequence 447855 from Patent EP1572962. HQ258637 - Synthetic construct Homo sapiens clone IMAGE:100073193 Unknown protein gene, encodes complete protein. JD475764 - Sequence 456788 from Patent EP1572962. JD380143 - Sequence 361167 from Patent EP1572962. JD116434 - Sequence 97458 from Patent EP1572962. JD132764 - Sequence 113788 from Patent EP1572962. JD144419 - Sequence 125443 from Patent EP1572962. JD180862 - Sequence 161886 from Patent EP1572962. JD495688 - Sequence 476712 from Patent EP1572962. JD182859 - Sequence 163883 from Patent EP1572962. JD133319 - Sequence 114343 from Patent EP1572962. JD076253 - Sequence 57277 from Patent EP1572962. JD530797 - Sequence 511821 from Patent EP1572962. JD211714 - Sequence 192738 from Patent EP1572962. JD443493 - Sequence 424517 from Patent EP1572962. JD445168 - Sequence 426192 from Patent EP1572962. JD422758 - Sequence 403782 from Patent EP1572962. JD471083 - Sequence 452107 from Patent EP1572962. JD133565 - Sequence 114589 from Patent EP1572962. JD282039 - Sequence 263063 from Patent EP1572962. JD070631 - Sequence 51655 from Patent EP1572962. JD232484 - Sequence 213508 from Patent EP1572962. JD346900 - Sequence 327924 from Patent EP1572962. JD540977 - Sequence 522001 from Patent EP1572962. JD483086 - Sequence 464110 from Patent EP1572962. JD202068 - Sequence 183092 from Patent EP1572962. JD318071 - Sequence 299095 from Patent EP1572962. JD173088 - Sequence 154112 from Patent EP1572962. JD355107 - Sequence 336131 from Patent EP1572962. JD482112 - Sequence 463136 from Patent EP1572962. JD470497 - Sequence 451521 from Patent EP1572962. JD297053 - Sequence 278077 from Patent EP1572962. JD501425 - Sequence 482449 from Patent EP1572962. JD187988 - Sequence 169012 from Patent EP1572962. JD276254 - Sequence 257278 from Patent EP1572962. JD091005 - Sequence 72029 from Patent EP1572962. JD439538 - Sequence 420562 from Patent EP1572962. JD040989 - Sequence 22013 from Patent EP1572962. JD378525 - Sequence 359549 from Patent EP1572962. JD311445 - Sequence 292469 from Patent EP1572962. JD504163 - Sequence 485187 from Patent EP1572962.

Other Names for This Gene


	Alternate Gene Symbols: AGRD1_HUMAN, B2CKK9, B7ZLF7, ENST00000261654.1, ENST00000261654.2, ENST00000261654.3, ENST00000261654.4, ENST00000261654.5, ENST00000261654.6, ENST00000261654.7, ENST00000261654.8, ENST00000261654.9, GPR133, NM_198827, PGR25, Q2M1L3, Q6QNK2, Q6ZMQ1, Q7Z7M2, Q86SM4, uc317gse.1, uc317gse.2 UCSC ID: ENST00000261654.10_11 RefSeq Accession: NM_198827.5 Protein: Q6QNK2 (aka GP133_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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