Human Gene GPR146 (ENST00000397095.2_2) from GENCODE V47lift37
  Description: G protein-coupled receptor 146, transcript variant 2 (from RefSeq NM_138445.4)
Gencode Transcript: ENST00000397095.2_2
Gencode Gene: ENSG00000164849.10_8
Transcript (Including UTRs)
   Position: hg19 chr7:1,094,921-1,098,897 Size: 3,977 Total Exon Count: 2 Strand: +
Coding Region
   Position: hg19 chr7:1,097,152-1,098,153 Size: 1,002 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr7:1,094,921-1,098,897)mRNA (may differ from genome)Protein (333 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsHGNC
MGIPubMedUniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: GP146_HUMAN
DESCRIPTION: RecName: Full=Probable G-protein coupled receptor 146; AltName: Full=G-protein coupled receptor PGR8;
FUNCTION: Orphan receptor.
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
SIMILARITY: Belongs to the G-protein coupled receptor 1 family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene
  • D013749 Tetrachlorodibenzodioxin
  • D001564 Benzo(a)pyrene
  • C006780 bisphenol A
  • C028474 1,4-bis(2-(3,5-dichloropyridyloxy))benzene
  • C014211 2,3,7,8-tetrachlorodibenzofuran
  • C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester
  • C532162 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine
  • D000082 Acetaminophen
  • D000535 Aluminum
  • D016572 Cyclosporine
          more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 21.73 RPKM in Adipose - Subcutaneous
Total median expression: 270.84 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -98.90223-0.443 Picture PostScript Text
3' UTR -215.70744-0.290 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000276 - 7TM_GPCR_Rhodpsn
IPR017452 - GPCR_Rhodpsn_supfam

Pfam Domains:
PF00001 - 7 transmembrane receptor (rhodopsin family)

SCOP Domains:
81321 - Family A G protein-coupled receptor-like

ModBase Predicted Comparative 3D Structure on Q96CH1
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGDEnsembl   
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004871 signal transducer activity
GO:0004930 G-protein coupled receptor activity

Biological Process:
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway

Cellular Component:
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  AK313171 - Homo sapiens cDNA, FLJ93668, Homo sapiens G protein-coupled receptor 146 (GPR146), mRNA.
AK300166 - Homo sapiens cDNA FLJ51301 complete cds, highly similar to Probable G-protein-coupled receptor 146.
BD295650 - WO 2003030936-A/1: Therapeutic Agent for Life-Style Related Diseases or Anorexia Nervosa, and Method for Screening Same.
BC014241 - Homo sapiens G protein-coupled receptor 146, mRNA (cDNA clone MGC:20737 IMAGE:4563636), complete cds.
AB464540 - Synthetic construct DNA, clone: pF1KB8797, Homo sapiens GPR146 gene for G protein-coupled receptor 146, without stop codon, in Flexi system.
DQ895899 - Synthetic construct Homo sapiens clone IMAGE:100010359; FLH188726.01L; RZPDo839F0663D G protein-coupled receptor 146 (GPR146) gene, encodes complete protein.
DQ892659 - Synthetic construct clone IMAGE:100005289; FLH188730.01X; RZPDo839F0673D G protein-coupled receptor 146 (GPR146) gene, encodes complete protein.
KJ895284 - Synthetic construct Homo sapiens clone ccsbBroadEn_04678 GPR146 gene, encodes complete protein.
AY255535 - Homo sapiens G protein-coupled receptor PGR8 mRNA, partial cds.
DQ593223 - Homo sapiens piRNA piR-33335, complete sequence.
JD468480 - Sequence 449504 from Patent EP1572962.
JD491733 - Sequence 472757 from Patent EP1572962.
JD048488 - Sequence 29512 from Patent EP1572962.
JD072787 - Sequence 53811 from Patent EP1572962.
JD271252 - Sequence 252276 from Patent EP1572962.
JD053299 - Sequence 34323 from Patent EP1572962.
JD111822 - Sequence 92846 from Patent EP1572962.
JD453945 - Sequence 434969 from Patent EP1572962.
JD410362 - Sequence 391386 from Patent EP1572962.
JD503032 - Sequence 484056 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000397095.1, GP146_HUMAN, NM_138445, PGR8, Q86SP5, Q96CH1, uc318ysx.1
UCSC ID: ENST00000397095.2_2
RefSeq Accession: NM_138445.4
Protein: Q96CH1 (aka GP146_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.