Human Gene GPR15 (ENST00000284311.5_4) from GENCODE V47lift37
  Description: G protein-coupled receptor 15 (from RefSeq NM_005290.4)
Gencode Transcript: ENST00000284311.5_4
Gencode Gene: ENSG00000154165.5_7
Transcript (Including UTRs)
   Position: hg19 chr3:98,250,822-98,253,525 Size: 2,704 Total Exon Count: 1 Strand: +
Coding Region
   Position: hg19 chr3:98,250,878-98,251,960 Size: 1,083 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr3:98,250,822-98,253,525)mRNA (may differ from genome)Protein (360 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedReactome
UniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: GPR15_HUMAN
DESCRIPTION: RecName: Full=G-protein coupled receptor 15; AltName: Full=Brother of Bonzo; Short=BoB;
FUNCTION: Probable chemokine receptor. Alternative coreceptor with CD4 for HIV-1 infection.
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
SIMILARITY: Belongs to the G-protein coupled receptor 1 family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: GPR15
Diseases sorted by gene-association score: mediastinal malignant lymphoma (1), mediastinal gray zone lymphoma (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 103.73 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 120.35 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -9.4056-0.168 Picture PostScript Text
3' UTR -334.801565-0.214 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000276 - 7TM_GPCR_Rhodpsn
IPR017452 - GPCR_Rhodpsn_supfam
IPR002286 - P2_purnocptor

Pfam Domains:
PF00001 - 7 transmembrane receptor (rhodopsin family)
PF02118 - Srg family chemoreceptor
PF10323 - Serpentine type 7TM GPCR chemoreceptor Srv

SCOP Domains:
81321 - Family A G protein-coupled receptor-like

ModBase Predicted Comparative 3D Structure on P49685
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0001618 virus receptor activity
GO:0004871 signal transducer activity
GO:0004930 G-protein coupled receptor activity
GO:0005515 protein binding
GO:0015026 coreceptor activity

Biological Process:
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0046718 viral entry into host cell
GO:0072678 T cell migration

Cellular Component:
GO:0005768 endosome
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  AK313375 - Homo sapiens cDNA, FLJ93906, highly similar to Homo sapiens G protein-coupled receptor 15 (GPR15), mRNA.
BC101779 - Homo sapiens G protein-coupled receptor 15, mRNA (cDNA clone MGC:126828 IMAGE:8069285), complete cds.
BC101781 - Homo sapiens G protein-coupled receptor 15, mRNA (cDNA clone MGC:126830 IMAGE:8069287), complete cds.
CU686810 - Synthetic construct Homo sapiens gateway clone IMAGE:100022622 5' read GPR15 mRNA.
HQ447483 - Synthetic construct Homo sapiens clone IMAGE:100070813; CCSB013877_01 G protein-coupled receptor 15 (GPR15) gene, encodes complete protein.
KJ896916 - Synthetic construct Homo sapiens clone ccsbBroadEn_06310 GPR15 gene, encodes complete protein.
BC069437 - Homo sapiens G protein-coupled receptor 15, mRNA (cDNA clone MGC:97025 IMAGE:7262234), complete cds.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein P49685 (Reactome details) participates in the following event(s):

R-HSA-744887 Liganded Gs-activating GPCRs bind inactive heterotrimeric Gs
R-HSA-744886 The Ligand:GPCR:Gs complex dissociates
R-HSA-379044 Liganded Gs-activating GPCR acts as a GEF for Gs
R-HSA-418555 G alpha (s) signalling events
R-HSA-388396 GPCR downstream signalling
R-HSA-372790 Signaling by GPCR
R-HSA-162582 Signal Transduction

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000284311.1, ENST00000284311.2, ENST00000284311.3, ENST00000284311.4, GPR15_HUMAN, NM_005290, P49685, Q3MIL4, Q6ISN6, uc317kes.1, uc317kes.2
UCSC ID: ENST00000284311.5_4
RefSeq Accession: NM_005290.4
Protein: P49685 (aka GPR15_HUMAN or GP15_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.