Human Gene GPR155 (ENST00000392552.7_11) from GENCODE V47lift37

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Description: G protein-coupled receptor 155, transcript variant 3 (from RefSeq NM_152529.7)
Gencode Transcript: ENST00000392552.7_11
Gencode Gene: ENSG00000163328.14_13
Transcript (Including UTRs)
Position: hg19 chr2:175,296,299-175,351,757 Size: 55,459 Total Exon Count: 16 Strand: -
Coding Region
Position: hg19 chr2:175,300,844-175,346,684 Size: 45,841 Coding Exon Count: 15

Page Index	Sequence and Links	UniProtKB Comments	Primers	CTD	Gene Alleles
RNA-Seq Expression	RNA Structure	Protein Structure	Other Species	GO Annotations	mRNA Descriptions
Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr2:175,296,299-175,351,757)			mRNA (may differ from genome)		Protein (870 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	MGI	PubMed	UniProtKB	Wikipedia	BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: GP155_HUMAN DESCRIPTION: RecName: Full=Integral membrane protein GPR155; AltName: Full=G-protein coupled receptor PGR22; SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. SIMILARITY: Contains 1 DEP domain. SEQUENCE CAUTION: Sequence=BAB71170.1; Type=Erroneous initiation;

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D013749 Tetrachlorodibenzodioxin C016403 2,4-dinitrotoluene C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester C028451 3,4,3',4'-tetrachlorobiphenyl D000082 Acetaminophen D016604 Aflatoxin B1 D001104 Arbutin D002251 Carbon Tetrachloride D002794 Choline D002922 Ciguatoxins more ... click here to view the complete list

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 11.96 RPKM in Stomach Total median expression: 189.89 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-83.60	188	-0.445	Picture	PostScript	Text
3' UTR	-1195.40	4545	-0.263	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR004776 - Auxin_eff
IPR000591 - DEP_dom
IPR011991 - WHTH_trsnscrt_rep_DNA-bd

Pfam Domains:
PF00610 - Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP)
PF03547 - Membrane transport protein

SCOP Domains:
46785 - "Winged helix" DNA-binding domain

ModBase Predicted Comparative 3D Structure on Q7Z3F1


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details
Gene Sorter	Gene Sorter
	RGD

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0003674 molecular_function Biological Process: GO:0035556 intracellular signal transduction GO:0050890 cognition GO:0055085 transmembrane transport Cellular Component: GO:0005737 cytoplasm GO:0016020 membrane GO:0016021 integral component of membrane GO:0070062 extracellular exosome

Descriptions from all associated GenBank mRNAs


	BC036681 - Homo sapiens G protein-coupled receptor 155, mRNA (cDNA clone IMAGE:5263578), complete cds. JD125131 - Sequence 106155 from Patent EP1572962. JD529337 - Sequence 510361 from Patent EP1572962. JD169541 - Sequence 150565 from Patent EP1572962. JD445229 - Sequence 426253 from Patent EP1572962. JD040936 - Sequence 21960 from Patent EP1572962. JD319824 - Sequence 300848 from Patent EP1572962. JD169018 - Sequence 150042 from Patent EP1572962. JD529041 - Sequence 510065 from Patent EP1572962. JD557275 - Sequence 538299 from Patent EP1572962. JD179046 - Sequence 160070 from Patent EP1572962. JD421435 - Sequence 402459 from Patent EP1572962. JD472383 - Sequence 453407 from Patent EP1572962. JD199441 - Sequence 180465 from Patent EP1572962. JD209030 - Sequence 190054 from Patent EP1572962. JD209031 - Sequence 190055 from Patent EP1572962. JD275818 - Sequence 256842 from Patent EP1572962. JD159104 - Sequence 140128 from Patent EP1572962. BC035037 - Homo sapiens G protein-coupled receptor 155, mRNA (cDNA clone MGC:33995 IMAGE:5260361), complete cds. JD105740 - Sequence 86764 from Patent EP1572962. JD511542 - Sequence 492566 from Patent EP1572962. JD558327 - Sequence 539351 from Patent EP1572962. JD522354 - Sequence 503378 from Patent EP1572962. JD564403 - Sequence 545427 from Patent EP1572962. JD556420 - Sequence 537444 from Patent EP1572962. JD319520 - Sequence 300544 from Patent EP1572962. JD118751 - Sequence 99775 from Patent EP1572962. JD188033 - Sequence 169057 from Patent EP1572962. JD475792 - Sequence 456816 from Patent EP1572962. AK096665 - Homo sapiens cDNA FLJ39346 fis, clone PEBLM1000024. BX537947 - Homo sapiens mRNA; cDNA DKFZp686D1686 (from clone DKFZp686D1686); complete cds. JD220771 - Sequence 201795 from Patent EP1572962. BC028730 - Homo sapiens G protein-coupled receptor 155, mRNA (cDNA clone MGC:33390 IMAGE:4813561), complete cds. JD287449 - Sequence 268473 from Patent EP1572962. JD292822 - Sequence 273846 from Patent EP1572962. AL834154 - Homo sapiens mRNA; cDNA DKFZp761A1011 (from clone DKFZp761A1011). AK056381 - Homo sapiens cDNA FLJ31819 fis, clone NT2RP6000032. JD517247 - Sequence 498271 from Patent EP1572962. JD344765 - Sequence 325789 from Patent EP1572962. JD344766 - Sequence 325790 from Patent EP1572962. JD194352 - Sequence 175376 from Patent EP1572962. JD353683 - Sequence 334707 from Patent EP1572962. JD071134 - Sequence 52158 from Patent EP1572962. JD048284 - Sequence 29308 from Patent EP1572962. JD443750 - Sequence 424774 from Patent EP1572962. JD171715 - Sequence 152739 from Patent EP1572962. JD530873 - Sequence 511897 from Patent EP1572962. JD430687 - Sequence 411711 from Patent EP1572962. JD179790 - Sequence 160814 from Patent EP1572962. JD294024 - Sequence 275048 from Patent EP1572962. JD481470 - Sequence 462494 from Patent EP1572962. JD303018 - Sequence 284042 from Patent EP1572962. JD174215 - Sequence 155239 from Patent EP1572962. JD142969 - Sequence 123993 from Patent EP1572962. AK315125 - Homo sapiens cDNA, FLJ96088. DQ891729 - Synthetic construct clone IMAGE:100004359; FLH179472.01X; RZPDo839G11130D G protein-coupled receptor 155 (GPR155) gene, encodes complete protein. DQ894906 - Synthetic construct Homo sapiens clone IMAGE:100009366; FLH179468.01L; RZPDo839G11129D G protein-coupled receptor 155 (GPR155) gene, encodes complete protein. AM393210 - Synthetic construct Homo sapiens clone IMAGE:100002474 for hypothetical protein (GPR155 gene). AK091200 - Homo sapiens cDNA FLJ33881 fis, clone CTONG2007168. AX746845 - Sequence 370 from Patent EP1308459. AY255528 - Homo sapiens G protein-coupled receptor PGR22 mRNA, partial cds. AK307896 - Homo sapiens cDNA, FLJ97844. JD194583 - Sequence 175607 from Patent EP1572962. JD292623 - Sequence 273647 from Patent EP1572962. JD560296 - Sequence 541320 from Patent EP1572962. JD525839 - Sequence 506863 from Patent EP1572962. JD537754 - Sequence 518778 from Patent EP1572962. JD424516 - Sequence 405540 from Patent EP1572962. JD058052 - Sequence 39076 from Patent EP1572962. JD173674 - Sequence 154698 from Patent EP1572962. JD058289 - Sequence 39313 from Patent EP1572962.

Other Names for This Gene


	Alternate Gene Symbols: B2RCI2, D3DPE2, ENST00000392552.1, ENST00000392552.2, ENST00000392552.3, ENST00000392552.4, ENST00000392552.5, ENST00000392552.6, GPR155 , LYCHS_HUMAN, NM_152529, PGR22 , Q4G0Y6, Q53SJ3, Q53TA8, Q69YG8, Q7Z3F1, Q86SP9, Q8N261, Q8N639, Q8N8K3, Q96MV6, uc318ven.1, uc318ven.2 UCSC ID: ENST00000392552.7_11 RefSeq Accession: NM_152529.7 Protein: Q7Z3F1 (aka GP155_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


	Click here for details on how this gene model was made and data restrictions if any.