Human Gene GPR161 (ENST00000682931.1_4) from GENCODE V47lift37
  Description: G protein-coupled receptor 161, transcript variant 15 (from RefSeq NM_001381909.1)
Gencode Transcript: ENST00000682931.1_4
Gencode Gene: ENSG00000143147.15_12
Transcript (Including UTRs)
   Position: hg19 chr1:168,048,780-168,106,168 Size: 57,389 Total Exon Count: 6 Strand: -
Coding Region
   Position: hg19 chr1:168,054,769-168,074,088 Size: 19,320 Coding Exon Count: 5 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:168,048,780-168,106,168)mRNA (may differ from genome)Protein (529 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCHuman Cortex Gene ExpressionMalacardsMGIOMIMPubMed
ReactomeUniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: GP161_HUMAN
DESCRIPTION: RecName: Full=G-protein coupled receptor 161; AltName: Full=G-protein coupled receptor RE2;
FUNCTION: Orphan receptor. Plays a role in neurulation and lens development (By similarity).
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
SIMILARITY: Belongs to the G-protein coupled receptor 1 family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: GPR161
Diseases sorted by gene-association score: pituitary stalk interruption syndrome* (175), spindle cell hemangioma (5)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
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+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -124.70236-0.528 Picture PostScript Text
3' UTR -1993.105989-0.333 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000276 - 7TM_GPCR_Rhodpsn
IPR017452 - GPCR_Rhodpsn_supfam

Pfam Domains:
PF00001 - 7 transmembrane receptor (rhodopsin family)

SCOP Domains:
81321 - Family A G protein-coupled receptor-like

ModBase Predicted Comparative 3D Structure on Q8N6U8
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004871 signal transducer activity
GO:0004930 G-protein coupled receptor activity

Biological Process:
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007275 multicellular organism development
GO:0030819 positive regulation of cAMP biosynthetic process
GO:1901621 negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning

Cellular Component:
GO:0005886 plasma membrane
GO:0005929 cilium
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030666 endocytic vesicle membrane
GO:0042995 cell projection
GO:0055037 recycling endosome
GO:0060170 ciliary membrane


-  Descriptions from all associated GenBank mRNAs
  AK091271 - Homo sapiens cDNA FLJ33952 fis, clone CTONG2018614.
AX746887 - Sequence 412 from Patent EP1308459.
AK026059 - Homo sapiens cDNA: FLJ22406 fis, clone HRC08351.
AK095302 - Homo sapiens cDNA FLJ37983 fis, clone CTONG2010649.
JD063049 - Sequence 44073 from Patent EP1572962.
JD204571 - Sequence 185595 from Patent EP1572962.
JD147494 - Sequence 128518 from Patent EP1572962.
JD197069 - Sequence 178093 from Patent EP1572962.
JD395744 - Sequence 376768 from Patent EP1572962.
JD107682 - Sequence 88706 from Patent EP1572962.
DQ591555 - Homo sapiens piRNA piR-58667, complete sequence.
JD020489 - Sequence 1513 from Patent EP1572962.
JD034220 - Sequence 15244 from Patent EP1572962.
JD030206 - Sequence 11230 from Patent EP1572962.
BC028163 - Homo sapiens G protein-coupled receptor 161, mRNA (cDNA clone MGC:39957 IMAGE:5246359), complete cds.
JD043764 - Sequence 24788 from Patent EP1572962.
JD323910 - Sequence 304934 from Patent EP1572962.
JD209855 - Sequence 190879 from Patent EP1572962.
JD186197 - Sequence 167221 from Patent EP1572962.
JD261809 - Sequence 242833 from Patent EP1572962.
JD411383 - Sequence 392407 from Patent EP1572962.
JD536641 - Sequence 517665 from Patent EP1572962.
JD233109 - Sequence 214133 from Patent EP1572962.
JD454592 - Sequence 435616 from Patent EP1572962.
JD216115 - Sequence 197139 from Patent EP1572962.
AK091869 - Homo sapiens cDNA FLJ34550 fis, clone HLUNG2009303.
AX747230 - Sequence 755 from Patent EP1308459.
AK056040 - Homo sapiens cDNA FLJ31478 fis, clone NT2NE2001626, highly similar to Probable G-protein coupled receptor 161.
AK298797 - Homo sapiens cDNA FLJ56129 complete cds, highly similar to Probable G-protein coupled receptor 161.
AK299634 - Homo sapiens cDNA FLJ55903 complete cds, highly similar to Probable G-protein coupled receptor 161.
AK298850 - Homo sapiens cDNA FLJ56130 complete cds, highly similar to Probable G-protein coupled receptor 161.
AK122656 - Homo sapiens cDNA FLJ16090 fis, clone OCBBF2001323, highly similar to Probable G-protein coupled receptor 161.
JD297420 - Sequence 278444 from Patent EP1572962.
JD287784 - Sequence 268808 from Patent EP1572962.
AK310019 - Homo sapiens cDNA, FLJ17061.
JD370844 - Sequence 351868 from Patent EP1572962.
JD368296 - Sequence 349320 from Patent EP1572962.
JD112663 - Sequence 93687 from Patent EP1572962.
JD407029 - Sequence 388053 from Patent EP1572962.
KJ893372 - Synthetic construct Homo sapiens clone ccsbBroadEn_02766 GPR161 gene, encodes complete protein.
AY275468 - Homo sapiens G-protein coupled receptor RE2 mRNA, complete cds.
DQ893369 - Synthetic construct clone IMAGE:100005999; FLH196690.01X; RZPDo839G07156D G protein-coupled receptor 161 (GPR161) gene, encodes complete protein.
DQ896689 - Synthetic construct Homo sapiens clone IMAGE:100011149; FLH196686.01L; RZPDo839G07155D G protein-coupled receptor 161 (GPR161) gene, encodes complete protein.
AF091890 - Homo sapiens G-protein coupled receptor RE2 mRNA, complete cds.
JD185566 - Sequence 166590 from Patent EP1572962.
JD121642 - Sequence 102666 from Patent EP1572962.
JD383234 - Sequence 364258 from Patent EP1572962.
JD375329 - Sequence 356353 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q8N6U8 (Reactome details) participates in the following event(s):

R-HSA-5610725 TULP3 is required for GPR161 localization in the cilium
R-HSA-5610787 Hedgehog 'off' state
R-HSA-5632684 Hedgehog 'on' state
R-HSA-5358351 Signaling by Hedgehog
R-HSA-162582 Signal Transduction

-  Other Names for This Gene
  Alternate Gene Symbols: B3KV34, B7Z5D7, B7Z5E8, B7Z5Z6, F5GXD6, F5H6J7, GP161_HUMAN, NM_001381909, O75963, Q5TGK0, Q5TGK1, Q5TGK2, Q8N6U8, uc330kqn.1, uc330kqn.2
UCSC ID: ENST00000682931.1_4
RefSeq Accession: NM_001375883.1
Protein: Q8N6U8 (aka GP161_HUMAN or G161_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.