Human Gene GPR173 (ENST00000332582.5_4) from GENCODE V47lift37
  Description: G protein-coupled receptor 173 (from RefSeq NM_018969.6)
Gencode Transcript: ENST00000332582.5_4
Gencode Gene: ENSG00000184194.6_10
Transcript (Including UTRs)
   Position: hg19 chrX:53,077,971-53,109,797 Size: 31,827 Total Exon Count: 2 Strand: +
Coding Region
   Position: hg19 chrX:53,105,804-53,106,925 Size: 1,122 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chrX:53,077,971-53,109,797)mRNA (may differ from genome)Protein (373 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCHuman Cortex Gene ExpressionMGIOMIMPubMedUniProtKB
WikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: GP173_HUMAN
DESCRIPTION: RecName: Full=Probable G-protein coupled receptor 173; AltName: Full=Super conserved receptor expressed in brain 3;
FUNCTION: Orphan receptor.
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein (By similarity).
TISSUE SPECIFICITY: Expressed at high levels in brain and ovary. Lower levels in small intestine. In brain regions, detected in all regions tested. Highest levels in the cerebellum and cerebral cortex.
SIMILARITY: Belongs to the G-protein coupled receptor 1 family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 17.15 RPKM in Pituitary
Total median expression: 200.05 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -395.60793-0.499 Picture PostScript Text
3' UTR -1081.102872-0.376 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000276 - 7TM_GPCR_Rhodpsn
IPR017452 - GPCR_Rhodpsn_supfam

Pfam Domains:
PF00001 - 7 transmembrane receptor (rhodopsin family)
PF13853 - Olfactory receptor

SCOP Domains:
81321 - Family A G protein-coupled receptor-like

ModBase Predicted Comparative 3D Structure on Q9NS66
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
  Ensembl   
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004871 signal transducer activity
GO:0004930 G-protein coupled receptor activity
GO:0004968 gonadotropin-releasing hormone receptor activity

Biological Process:
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0097211 cellular response to gonadotropin-releasing hormone
GO:2001223 negative regulation of neuron migration

Cellular Component:
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  LF211702 - JP 2014500723-A/19205: Polycomb-Associated Non-Coding RNAs.
BC009861 - Homo sapiens G protein-coupled receptor 173, mRNA (cDNA clone MGC:16375 IMAGE:3936037), complete cds.
LF385360 - JP 2014500723-A/192863: Polycomb-Associated Non-Coding RNAs.
MA620937 - JP 2018138019-A/192863: Polycomb-Associated Non-Coding RNAs.
MA447279 - JP 2018138019-A/19205: Polycomb-Associated Non-Coding RNAs.
JD207992 - Sequence 189016 from Patent EP1572962.
JD100708 - Sequence 81732 from Patent EP1572962.
JD210685 - Sequence 191709 from Patent EP1572962.
CU679515 - Synthetic construct Homo sapiens gateway clone IMAGE:100023382 5' read GPR173 mRNA.
AB385590 - Synthetic construct DNA, clone: pF1KB9519, Homo sapiens GPR173 gene for G-protein coupled receptor 173, complete cds, without stop codon, in Flexi system.
DQ893276 - Synthetic construct clone IMAGE:100005906; FLH195866.01X; RZPDo839H02152D G protein-coupled receptor 173 (GPR173) gene, encodes complete protein.
DQ896607 - Synthetic construct Homo sapiens clone IMAGE:100011067; FLH195862.01L; RZPDo839H02151D G protein-coupled receptor 173 (GPR173) gene, encodes complete protein.
KJ898972 - Synthetic construct Homo sapiens clone ccsbBroadEn_08366 GPR173 gene, encodes complete protein.
AB040801 - Homo sapiens mRNA for SREB3, complete cds.
JD382406 - Sequence 363430 from Patent EP1572962.
JD107989 - Sequence 89013 from Patent EP1572962.
JD110166 - Sequence 91190 from Patent EP1572962.
JD399128 - Sequence 380152 from Patent EP1572962.
JD403876 - Sequence 384900 from Patent EP1572962.
JD167104 - Sequence 148128 from Patent EP1572962.
JD404380 - Sequence 385404 from Patent EP1572962.
JD160264 - Sequence 141288 from Patent EP1572962.
JD060695 - Sequence 41719 from Patent EP1572962.
JD566315 - Sequence 547339 from Patent EP1572962.
JD547988 - Sequence 529012 from Patent EP1572962.
JD399061 - Sequence 380085 from Patent EP1572962.
LF382804 - JP 2014500723-A/190307: Polycomb-Associated Non-Coding RNAs.
LF382803 - JP 2014500723-A/190306: Polycomb-Associated Non-Coding RNAs.
LF382802 - JP 2014500723-A/190305: Polycomb-Associated Non-Coding RNAs.
BC013072 - Homo sapiens cDNA clone IMAGE:4151570, partial cds.
MA618381 - JP 2018138019-A/190307: Polycomb-Associated Non-Coding RNAs.
MA618380 - JP 2018138019-A/190306: Polycomb-Associated Non-Coding RNAs.
MA618379 - JP 2018138019-A/190305: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: B1B0A5, ENST00000332582.1, ENST00000332582.2, ENST00000332582.3, ENST00000332582.4, GP173_HUMAN, NM_018969, Q9NS66, SREB3, uc317tlx.1, uc317tlx.2
UCSC ID: ENST00000332582.5_4
RefSeq Accession: NM_018969.6
Protein: Q9NS66 (aka GP173_HUMAN or G173_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.