Human Gene GPR174 (ENST00000645147.2_4) from GENCODE V47lift37
  Description: G protein-coupled receptor 174 (from RefSeq NM_032553.3)
Gencode Transcript: ENST00000645147.2_4
Gencode Gene: ENSG00000147138.3_8
Transcript (Including UTRs)
   Position: hg19 chrX:78,400,185-78,430,815 Size: 30,631 Total Exon Count: 3 Strand: +
Coding Region
   Position: hg19 chrX:78,426,505-78,427,506 Size: 1,002 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsGene Alleles
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chrX:78,400,185-78,430,815)mRNA (may differ from genome)Protein (333 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
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HGNCMalacardsMGIOMIMPubMedUniProtKB
WikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: GP174_HUMAN
DESCRIPTION: RecName: Full=Probable G-protein coupled receptor 174;
FUNCTION: Putative receptor for purines coupled to G-proteins (By similarity).
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
SIMILARITY: Belongs to the G-protein coupled receptor 1 family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: GPR174
Diseases sorted by gene-association score: autoimmune polyendocrine syndrome, type ii (8), autoimmune disease of endocrine system (5)

+  Common Gene Haplotype Alleles
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+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -236.501183-0.200 Picture PostScript Text
3' UTR -810.403309-0.245 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000276 - 7TM_GPCR_Rhodpsn
IPR017452 - GPCR_Rhodpsn_supfam
IPR002286 - P2_purnocptor

Pfam Domains:
PF00001 - 7 transmembrane receptor (rhodopsin family)

SCOP Domains:
81321 - Family A G protein-coupled receptor-like

ModBase Predicted Comparative 3D Structure on Q9BXC1
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004871 signal transducer activity
GO:0004930 G-protein coupled receptor activity

Biological Process:
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway

Cellular Component:
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  BC104922 - Homo sapiens G protein-coupled receptor 174, mRNA (cDNA clone MGC:132582 IMAGE:8143925), complete cds.
BC104924 - Homo sapiens G protein-coupled receptor 174, mRNA (cDNA clone MGC:132584 IMAGE:8143927), complete cds.
AF345567 - Homo sapiens putative purinergic receptor (FKSG79) mRNA, complete cds.
KJ899813 - Synthetic construct Homo sapiens clone ccsbBroadEn_09207 GPR174 gene, encodes complete protein.
JD168869 - Sequence 149893 from Patent EP1572962.
JD510597 - Sequence 491621 from Patent EP1572962.
JD062098 - Sequence 43122 from Patent EP1572962.
JD360881 - Sequence 341905 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000645147.1, FKSG79, GP174_HUMAN, GPCR17, NM_032553, Q2M3F7, Q9BXC1, uc328lho.1, uc328lho.2
UCSC ID: ENST00000645147.2_4
RefSeq Accession: NM_032553.3
Protein: Q9BXC1 (aka GP174_HUMAN or FK79_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.