Human Gene GPR22 (ENST00000304402.6_4) from GENCODE V47lift37
  Description: G protein-coupled receptor 22 (from RefSeq NM_005295.3)
Gencode Transcript: ENST00000304402.6_4
Gencode Gene: ENSG00000172209.6_7
Transcript (Including UTRs)
   Position: hg19 chr7:107,110,502-107,116,129 Size: 5,628 Total Exon Count: 3 Strand: +
Coding Region
   Position: hg19 chr7:107,114,506-107,115,807 Size: 1,302 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr7:107,110,502-107,116,129)mRNA (may differ from genome)Protein (433 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsHGNC
Human Cortex Gene ExpressionMGIOMIMPubMedUniProtKBWikipedia
BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: GPR22_HUMAN
DESCRIPTION: RecName: Full=Probable G-protein coupled receptor 22;
FUNCTION: Orphan receptor.
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: In the brain regions frontal cortex, caudate, putamen and thalamus; not in pons, hypothalamus and hippocampus.
SIMILARITY: Belongs to the G-protein coupled receptor 1 family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 6.77 RPKM in Brain - Frontal Cortex (BA9)
Total median expression: 42.98 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -273.301346-0.203 Picture PostScript Text
3' UTR -52.50322-0.163 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000276 - 7TM_GPCR_Rhodpsn
IPR017452 - GPCR_Rhodpsn_supfam

Pfam Domains:
PF00001 - 7 transmembrane receptor (rhodopsin family)

SCOP Domains:
81321 - Family A G protein-coupled receptor-like

ModBase Predicted Comparative 3D Structure on Q99680
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004871 signal transducer activity
GO:0004930 G-protein coupled receptor activity
GO:0042277 peptide binding

Biological Process:
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0032870 cellular response to hormone stimulus
GO:1901652 response to peptide

Cellular Component:
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  AK307393 - Homo sapiens cDNA, FLJ97341.
AK122621 - Homo sapiens cDNA FLJ16041 fis, clone BRACE2006937, highly similar to Probable G-protein coupled receptor 22.
BC045823 - Homo sapiens G protein-coupled receptor 22, mRNA (cDNA clone IMAGE:5261153), with apparent retained intron.
BX647649 - Homo sapiens mRNA; cDNA DKFZp686D02199 (from clone DKFZp686D02199).
AB209270 - Homo sapiens mRNA for G protein-coupled receptor 22 variant protein.
AB384903 - Synthetic construct DNA, clone: pF1KB4126, Homo sapiens GPR22 gene for G-protein coupled receptor 22, complete cds, without stop codon, in Flexi system.
KJ896919 - Synthetic construct Homo sapiens clone ccsbBroadEn_06313 GPR22 gene, encodes complete protein.
BC107128 - Homo sapiens G protein-coupled receptor 22, mRNA (cDNA clone MGC:129847 IMAGE:40024013), complete cds.
HQ995527 - Homo sapiens G protein-coupled receptor 22 (GPR22) mRNA, complete cds.

-  Other Names for This Gene
  Alternate Gene Symbols: A4D0R8, ENST00000304402.1, ENST00000304402.2, ENST00000304402.3, ENST00000304402.4, ENST00000304402.5, GPR22 , GPR22_HUMAN, NM_005295, O14554, Q99680, uc317nkp.1, uc317nkp.2
UCSC ID: ENST00000304402.6_4
RefSeq Accession: NM_005295.3
Protein: Q99680 (aka GPR22_HUMAN or GP22_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.