Human Gene GPR26 (ENST00000284674.2_4) from GENCODE V47lift37
  Description: G protein-coupled receptor 26 (from RefSeq NM_153442.4)
Gencode Transcript: ENST00000284674.2_4
Gencode Gene: ENSG00000154478.4_7
Transcript (Including UTRs)
   Position: hg19 chr10:125,425,871-125,456,915 Size: 31,045 Total Exon Count: 3 Strand: +
Coding Region
   Position: hg19 chr10:125,425,924-125,447,676 Size: 21,753 Coding Exon Count: 3 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr10:125,425,871-125,456,915)mRNA (may differ from genome)Protein (337 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMGIOMIMPubMedUniProtKBWikipedia
BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: GPR26_HUMAN
DESCRIPTION: RecName: Full=G-protein coupled receptor 26;
FUNCTION: Orphan receptor. Displays a significant level of constitutive activity. Its effect is mediated by G(s)-alpha protein that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP.
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: Highly expressed in the CNS, the highest expression is seen in the amygdala, hippocampus and thalamus. Weak expression is detected in testis. Down-regulated in glioblastoma.
SIMILARITY: Belongs to the G-protein coupled receptor 1 family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 1.21 RPKM in Brain - Frontal Cortex (BA9)
Total median expression: 7.47 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -27.4053-0.517 Picture PostScript Text
3' UTR -3037.209239-0.329 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000276 - 7TM_GPCR_Rhodpsn
IPR017452 - GPCR_Rhodpsn_supfam

Pfam Domains:
PF00001 - 7 transmembrane receptor (rhodopsin family)
PF10320 - Serpentine type 7TM GPCR chemoreceptor Srsx

SCOP Domains:
81321 - Family A G protein-coupled receptor-like

ModBase Predicted Comparative 3D Structure on Q8NDV2
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGDEnsembl   
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004871 signal transducer activity
GO:0004930 G-protein coupled receptor activity

Biological Process:
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway

Cellular Component:
GO:0005622 intracellular
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  KJ896923 - Synthetic construct Homo sapiens clone ccsbBroadEn_06317 GPR26 gene, encodes complete protein.
AJ505757 - Homo sapiens mRNA for putative orphan G protein-coupled receptor 26 (GPR26 gene).
BC113462 - Homo sapiens G protein-coupled receptor 26, mRNA (cDNA clone MGC:142022 IMAGE:8322514), complete cds.
BC112011 - Homo sapiens G protein-coupled receptor 26, mRNA (cDNA clone MGC:138216 IMAGE:8327479), complete cds.
JD154934 - Sequence 135958 from Patent EP1572962.
JD383295 - Sequence 364319 from Patent EP1572962.
JD279595 - Sequence 260619 from Patent EP1572962.
JD131338 - Sequence 112362 from Patent EP1572962.
JD338150 - Sequence 319174 from Patent EP1572962.
JD533360 - Sequence 514384 from Patent EP1572962.
JD263792 - Sequence 244816 from Patent EP1572962.
JD188061 - Sequence 169085 from Patent EP1572962.
JD149906 - Sequence 130930 from Patent EP1572962.
JD518605 - Sequence 499629 from Patent EP1572962.
JD448546 - Sequence 429570 from Patent EP1572962.
JD268534 - Sequence 249558 from Patent EP1572962.
JD353899 - Sequence 334923 from Patent EP1572962.
JD120183 - Sequence 101207 from Patent EP1572962.
JD295983 - Sequence 277007 from Patent EP1572962.
JD138369 - Sequence 119393 from Patent EP1572962.
JD247470 - Sequence 228494 from Patent EP1572962.
JD326082 - Sequence 307106 from Patent EP1572962.
JD153805 - Sequence 134829 from Patent EP1572962.
JD528548 - Sequence 509572 from Patent EP1572962.
JD553582 - Sequence 534606 from Patent EP1572962.
JD293196 - Sequence 274220 from Patent EP1572962.
JD559421 - Sequence 540445 from Patent EP1572962.
JD157176 - Sequence 138200 from Patent EP1572962.
JD352263 - Sequence 333287 from Patent EP1572962.
JD341562 - Sequence 322586 from Patent EP1572962.
JD364106 - Sequence 345130 from Patent EP1572962.
JD419531 - Sequence 400555 from Patent EP1572962.
JD171275 - Sequence 152299 from Patent EP1572962.
JD380854 - Sequence 361878 from Patent EP1572962.
JD512197 - Sequence 493221 from Patent EP1572962.
JD381451 - Sequence 362475 from Patent EP1572962.
JD555491 - Sequence 536515 from Patent EP1572962.
JD408740 - Sequence 389764 from Patent EP1572962.
JD047222 - Sequence 28246 from Patent EP1572962.
JD092857 - Sequence 73881 from Patent EP1572962.
JD147919 - Sequence 128943 from Patent EP1572962.
JD201800 - Sequence 182824 from Patent EP1572962.
JD165525 - Sequence 146549 from Patent EP1572962.
JD096623 - Sequence 77647 from Patent EP1572962.
JD093785 - Sequence 74809 from Patent EP1572962.
JD257285 - Sequence 238309 from Patent EP1572962.
JD362993 - Sequence 344017 from Patent EP1572962.
JD316746 - Sequence 297770 from Patent EP1572962.
JD096010 - Sequence 77034 from Patent EP1572962.
JD471336 - Sequence 452360 from Patent EP1572962.
JD451318 - Sequence 432342 from Patent EP1572962.
JD342736 - Sequence 323760 from Patent EP1572962.
JD228106 - Sequence 209130 from Patent EP1572962.
JD356839 - Sequence 337863 from Patent EP1572962.
JD559691 - Sequence 540715 from Patent EP1572962.
JD273619 - Sequence 254643 from Patent EP1572962.
JD078231 - Sequence 59255 from Patent EP1572962.
JD245853 - Sequence 226877 from Patent EP1572962.
JD277835 - Sequence 258859 from Patent EP1572962.
JD258697 - Sequence 239721 from Patent EP1572962.
JD067845 - Sequence 48869 from Patent EP1572962.
JD547158 - Sequence 528182 from Patent EP1572962.
JD486473 - Sequence 467497 from Patent EP1572962.
JD507766 - Sequence 488790 from Patent EP1572962.
JD394256 - Sequence 375280 from Patent EP1572962.
JD514542 - Sequence 495566 from Patent EP1572962.
JD077001 - Sequence 58025 from Patent EP1572962.
JD449339 - Sequence 430363 from Patent EP1572962.
JD093733 - Sequence 74757 from Patent EP1572962.
JD466419 - Sequence 447443 from Patent EP1572962.
JD041487 - Sequence 22511 from Patent EP1572962.
JD078576 - Sequence 59600 from Patent EP1572962.
JD485966 - Sequence 466990 from Patent EP1572962.
JD071841 - Sequence 52865 from Patent EP1572962.
JD561884 - Sequence 542908 from Patent EP1572962.
JD499237 - Sequence 480261 from Patent EP1572962.
JD417827 - Sequence 398851 from Patent EP1572962.
JD278982 - Sequence 260006 from Patent EP1572962.
JD221686 - Sequence 202710 from Patent EP1572962.
JD322240 - Sequence 303264 from Patent EP1572962.
JD528781 - Sequence 509805 from Patent EP1572962.
JD450357 - Sequence 431381 from Patent EP1572962.
JD051888 - Sequence 32912 from Patent EP1572962.
JD500715 - Sequence 481739 from Patent EP1572962.
JD432140 - Sequence 413164 from Patent EP1572962.
JD177006 - Sequence 158030 from Patent EP1572962.
JD372032 - Sequence 353056 from Patent EP1572962.
JD543615 - Sequence 524639 from Patent EP1572962.
JD479254 - Sequence 460278 from Patent EP1572962.
JD135104 - Sequence 116128 from Patent EP1572962.
JD041797 - Sequence 22821 from Patent EP1572962.
JD060682 - Sequence 41706 from Patent EP1572962.
JD304929 - Sequence 285953 from Patent EP1572962.
JD367166 - Sequence 348190 from Patent EP1572962.
JD241958 - Sequence 222982 from Patent EP1572962.
JD341584 - Sequence 322608 from Patent EP1572962.
JD501716 - Sequence 482740 from Patent EP1572962.
JD136773 - Sequence 117797 from Patent EP1572962.
JD200135 - Sequence 181159 from Patent EP1572962.
JD260412 - Sequence 241436 from Patent EP1572962.
JD445357 - Sequence 426381 from Patent EP1572962.
JD073244 - Sequence 54268 from Patent EP1572962.
JD202224 - Sequence 183248 from Patent EP1572962.
JD263467 - Sequence 244491 from Patent EP1572962.
JD274748 - Sequence 255772 from Patent EP1572962.
JD543609 - Sequence 524633 from Patent EP1572962.
JD479235 - Sequence 460259 from Patent EP1572962.
JD204870 - Sequence 185894 from Patent EP1572962.
JD140925 - Sequence 121949 from Patent EP1572962.
JD159729 - Sequence 140753 from Patent EP1572962.
JD053747 - Sequence 34771 from Patent EP1572962.
JD305361 - Sequence 286385 from Patent EP1572962.
JD049043 - Sequence 30067 from Patent EP1572962.
JD221035 - Sequence 202059 from Patent EP1572962.
JD201025 - Sequence 182049 from Patent EP1572962.
JD176020 - Sequence 157044 from Patent EP1572962.
JD527595 - Sequence 508619 from Patent EP1572962.
JD070777 - Sequence 51801 from Patent EP1572962.
JD497154 - Sequence 478178 from Patent EP1572962.
JD148652 - Sequence 129676 from Patent EP1572962.
JD114079 - Sequence 95103 from Patent EP1572962.
JD145320 - Sequence 126344 from Patent EP1572962.
JD078597 - Sequence 59621 from Patent EP1572962.
JD485959 - Sequence 466983 from Patent EP1572962.
JD486262 - Sequence 467286 from Patent EP1572962.
JD076939 - Sequence 57963 from Patent EP1572962.
JD061550 - Sequence 42574 from Patent EP1572962.
JD072558 - Sequence 53582 from Patent EP1572962.
JD170473 - Sequence 151497 from Patent EP1572962.
JD214477 - Sequence 195501 from Patent EP1572962.
JD451002 - Sequence 432026 from Patent EP1572962.
JD355879 - Sequence 336903 from Patent EP1572962.
JD065248 - Sequence 46272 from Patent EP1572962.
JD302017 - Sequence 283041 from Patent EP1572962.
JD302018 - Sequence 283042 from Patent EP1572962.
JD043527 - Sequence 24551 from Patent EP1572962.
AK091093 - Homo sapiens cDNA FLJ33774 fis, clone BRSSN2000244.
AL713636 - Homo sapiens mRNA; cDNA DKFZp761H2121 (from clone DKFZp761H2121).
JD281919 - Sequence 262943 from Patent EP1572962.
JD115369 - Sequence 96393 from Patent EP1572962.
JD563029 - Sequence 544053 from Patent EP1572962.
JD315745 - Sequence 296769 from Patent EP1572962.
JD273125 - Sequence 254149 from Patent EP1572962.
JD090177 - Sequence 71201 from Patent EP1572962.
JD345147 - Sequence 326171 from Patent EP1572962.
JD185555 - Sequence 166579 from Patent EP1572962.
JD096552 - Sequence 77576 from Patent EP1572962.
JD486791 - Sequence 467815 from Patent EP1572962.
JD282043 - Sequence 263067 from Patent EP1572962.
JD292293 - Sequence 273317 from Patent EP1572962.
JD454447 - Sequence 435471 from Patent EP1572962.
JD106579 - Sequence 87603 from Patent EP1572962.
JD251081 - Sequence 232105 from Patent EP1572962.
JD561581 - Sequence 542605 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  BioCarta from NCI Cancer Genome Anatomy Project
h_akap13Pathway - Rho-Selective Guanine Exchange Factor AKAP13 Mediates Stress Fiber Formation

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000284674.1, GPR26_HUMAN, NM_153442, Q2M2E2, Q8NDV2, uc317kfs.1, uc317kfs.2
UCSC ID: ENST00000284674.2_4
RefSeq Accession: NM_153442.4
Protein: Q8NDV2 (aka GPR26_HUMAN or GP26_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.