Human Gene GPR45 (ENST00000258456.3_4) from GENCODE V47lift37
  Description: G protein-coupled receptor 45 (from RefSeq NM_007227.3)
Gencode Transcript: ENST00000258456.3_4
Gencode Gene: ENSG00000135973.3_7
Transcript (Including UTRs)
   Position: hg19 chr2:105,858,200-105,859,924 Size: 1,725 Total Exon Count: 1 Strand: +
Coding Region
   Position: hg19 chr2:105,858,316-105,859,434 Size: 1,119 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr2:105,858,200-105,859,924)mRNA (may differ from genome)Protein (372 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMGIOMIMPubMedReactomeUniProtKB
WikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: GPR45_HUMAN
DESCRIPTION: RecName: Full=Probable G-protein coupled receptor 45; AltName: Full=PSP24-1; AltName: Full=PSP24-alpha;
FUNCTION: Orphan receptor. May play a role in brain function.
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: Expressed in brain; detected in the basal forebrain, frontal cortex, and caudate, but not in thalamus, hippocampus, or putamen.
SIMILARITY: Belongs to the G-protein coupled receptor 1 family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 0.72 RPKM in Brain - Cortex
Total median expression: 7.20 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -32.10116-0.277 Picture PostScript Text
3' UTR -181.90490-0.371 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000276 - 7TM_GPCR_Rhodpsn
IPR017452 - GPCR_Rhodpsn_supfam

Pfam Domains:
PF00001 - 7 transmembrane receptor (rhodopsin family)

SCOP Domains:
81321 - Family A G protein-coupled receptor-like

ModBase Predicted Comparative 3D Structure on Q9Y5Y3
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004871 signal transducer activity
GO:0004930 G-protein coupled receptor activity

Biological Process:
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway

Cellular Component:
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  BC066879 - Homo sapiens G protein-coupled receptor 45, mRNA (cDNA clone MGC:79286 IMAGE:6971748), complete cds.
BC066880 - Homo sapiens G protein-coupled receptor 45, mRNA (cDNA clone MGC:79288 IMAGE:6971750), complete cds.
BC067455 - Homo sapiens G protein-coupled receptor 45, mRNA (cDNA clone MGC:79287 IMAGE:6971749), complete cds.
U92642 - Homo sapiens high-affinity lysophosphatidic acid receptor homolog mRNA, complete cds.
JD103131 - Sequence 84155 from Patent EP1572962.
JD328825 - Sequence 309849 from Patent EP1572962.
JD474640 - Sequence 455664 from Patent EP1572962.
CU688176 - Synthetic construct Homo sapiens gateway clone IMAGE:100022900 5' read GPR45 mRNA.
KJ893263 - Synthetic construct Homo sapiens clone ccsbBroadEn_02657 GPR45 gene, encodes complete protein.
EU883573 - Homo sapiens orphan GPCR 45 (GPR45) mRNA, complete cds.
JD219504 - Sequence 200528 from Patent EP1572962.
JD279023 - Sequence 260047 from Patent EP1572962.
JD277776 - Sequence 258800 from Patent EP1572962.
JD108317 - Sequence 89341 from Patent EP1572962.
JD443280 - Sequence 424304 from Patent EP1572962.
JD197632 - Sequence 178656 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q9Y5Y3 (Reactome details) participates in the following event(s):

R-HSA-744887 Liganded Gs-activating GPCRs bind inactive heterotrimeric Gs
R-HSA-744886 The Ligand:GPCR:Gs complex dissociates
R-HSA-379044 Liganded Gs-activating GPCR acts as a GEF for Gs
R-HSA-418555 G alpha (s) signalling events
R-HSA-388396 GPCR downstream signalling
R-HSA-372790 Signaling by GPCR
R-HSA-162582 Signal Transduction

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000258456.1, ENST00000258456.2, GPR45_HUMAN, NM_007227, Q6NWS4, Q6NXU6, Q9Y5Y3, uc317gcx.1, uc317gcx.2
UCSC ID: ENST00000258456.3_4
RefSeq Accession: NM_007227.3
Protein: Q9Y5Y3 (aka GPR45_HUMAN or GP45_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.