Human Gene GPR50 (ENST00000218316.4_5) from GENCODE V47lift37
  Description: G protein-coupled receptor 50 (from RefSeq NM_004224.3)
Gencode Transcript: ENST00000218316.4_5
Gencode Gene: ENSG00000102195.10_8
Transcript (Including UTRs)
   Position: hg19 chrX:150,345,056-150,349,937 Size: 4,882 Total Exon Count: 2 Strand: +
Coding Region
   Position: hg19 chrX:150,345,194-150,349,909 Size: 4,716 Coding Exon Count: 2 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chrX:150,345,056-150,349,937)mRNA (may differ from genome)Protein (617 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCHuman Cortex Gene ExpressionMGIOMIMPubMedUniProtKB
WikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: MTR1L_HUMAN
DESCRIPTION: RecName: Full=Melatonin-related receptor; AltName: Full=G protein-coupled receptor 50; AltName: Full=H9;
FUNCTION: Does not bind melatonin.
SUBUNIT: Homodimer, and heterodimer with MTNR1A and MTNR1B.
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: Hypothalamus and pituitary.
SIMILARITY: Belongs to the G-protein coupled receptor 1 family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 12.71 RPKM in Pituitary
Total median expression: 13.03 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -54.40138-0.394 Picture PostScript Text
3' UTR -3.6028-0.129 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000276 - 7TM_GPCR_Rhodpsn
IPR017452 - GPCR_Rhodpsn_supfam
IPR002280 - Mel_rcpt_1X
IPR000025 - Melatonin_rcpt

Pfam Domains:
PF00001 - 7 transmembrane receptor (rhodopsin family)
PF10320 - Serpentine type 7TM GPCR chemoreceptor Srsx
PF10328 - Serpentine type 7TM GPCR chemoreceptor Srx

SCOP Domains:
81321 - Family A G protein-coupled receptor-like

ModBase Predicted Comparative 3D Structure on Q13585
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004871 signal transducer activity
GO:0004930 G-protein coupled receptor activity
GO:0005515 protein binding
GO:0008502 melatonin receptor activity
GO:0042802 identical protein binding

Biological Process:
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007267 cell-cell signaling

Cellular Component:
GO:0005654 nucleoplasm
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  U52219 - Human melatonin-related receptor mRNA, complete cds.
BC103696 - Homo sapiens G protein-coupled receptor 50, mRNA (cDNA clone MGC:125342 IMAGE:40006713), complete cds.
BC105683 - Homo sapiens G protein-coupled receptor 50, mRNA (cDNA clone MGC:125344 IMAGE:40006718), complete cds.
BC105684 - Homo sapiens G protein-coupled receptor 50, mRNA (cDNA clone MGC:125343 IMAGE:40006715), complete cds.
JD123818 - Sequence 104842 from Patent EP1572962.
EU432118 - Homo sapiens G protein-coupled receptor 50 (GPR50) mRNA, complete cds.
AY114101 - Homo sapiens G protein-coupled receptor 50 variant b (GPR50) mRNA, partial cds; alternatively spliced.
AY114102 - Homo sapiens G protein-coupled receptor 50 variant c (GPR50) mRNA, partial cds; alternatively spliced.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000218316.1, ENST00000218316.2, ENST00000218316.3, MTR1L_HUMAN, NM_004224, Q0VGG3, Q13585, Q3ZAR0, uc317cvj.1, uc317cvj.2
UCSC ID: ENST00000218316.4_5
RefSeq Accession: NM_004224.3
Protein: Q13585 (aka MTR1L_HUMAN or ML1X_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.