Human Gene GPR83 (ENST00000243673.7_7) from GENCODE V47lift37
  Description: G protein-coupled receptor 83, transcript variant 1 (from RefSeq NM_016540.4)
Gencode Transcript: ENST00000243673.7_7
Gencode Gene: ENSG00000123901.9_15
Transcript (Including UTRs)
   Position: hg19 chr11:94,110,482-94,134,585 Size: 24,104 Total Exon Count: 4 Strand: -
Coding Region
   Position: hg19 chr11:94,113,315-94,134,413 Size: 21,099 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr11:94,110,482-94,134,585)mRNA (may differ from genome)Protein (423 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCHuman Cortex Gene ExpressionMGIOMIMPubMedReactome
UniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: GPR83_HUMAN
DESCRIPTION: RecName: Full=Probable G-protein coupled receptor 83; AltName: Full=G-protein coupled receptor 72; Flags: Precursor;
FUNCTION: Orphan receptor. Could be a neuropeptide Y receptor.
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: Brain specific.
SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
SEQUENCE CAUTION: Sequence=BAA96064.1; Type=Erroneous initiation;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 10.92 RPKM in Brain - Cerebellar Hemisphere
Total median expression: 41.01 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -87.60172-0.509 Picture PostScript Text
3' UTR -865.602833-0.306 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000276 - 7TM_GPCR_Rhodpsn
IPR017452 - GPCR_Rhodpsn_supfam
IPR000611 - NPY_rcpt

Pfam Domains:
PF00001 - 7 transmembrane receptor (rhodopsin family)
PF10320 - Serpentine type 7TM GPCR chemoreceptor Srsx
PF13853 - Olfactory receptor

SCOP Domains:
81321 - Family A G protein-coupled receptor-like

ModBase Predicted Comparative 3D Structure on Q9NYM4
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004871 signal transducer activity
GO:0004930 G-protein coupled receptor activity
GO:0004983 neuropeptide Y receptor activity

Biological Process:
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007218 neuropeptide signaling pathway
GO:0051384 response to glucocorticoid

Cellular Component:
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0097730 non-motile cilium


-  Descriptions from all associated GenBank mRNAs
  AB040973 - Homo sapiens KIAA1540 mRNA for KIAA1540 protein.
JD531618 - Sequence 512642 from Patent EP1572962.
AF236081 - Homo sapiens orphan G-protein coupled receptor GPR72 (GPR72) mRNA, complete cds.
BC067473 - Homo sapiens G protein-coupled receptor 83, mRNA (cDNA clone MGC:79307 IMAGE:6971838), complete cds.
BC067474 - Homo sapiens G protein-coupled receptor 83, mRNA (cDNA clone MGC:79308 IMAGE:6971839), complete cds.
JD470756 - Sequence 451780 from Patent EP1572962.
JD419153 - Sequence 400177 from Patent EP1572962.
JD528632 - Sequence 509656 from Patent EP1572962.
JD234673 - Sequence 215697 from Patent EP1572962.
EU432120 - Homo sapiens G protein-coupled receptor 83 (GPR83) mRNA, complete cds.
AK315161 - Homo sapiens cDNA, FLJ96135, highly similar to Homo sapiens G protein-coupled receptor 72 (GPR72), mRNA.
AB384231 - Synthetic construct DNA, clone: pF1KSDA1540, Homo sapiens GPR83 gene for G-protein coupled receptor 83, complete cds, without stop codon, in Flexi system.
HQ447569 - Synthetic construct Homo sapiens clone IMAGE:100070910; CCSB014583_01 G protein-coupled receptor 83 (GPR83) gene, encodes complete protein.
KJ898305 - Synthetic construct Homo sapiens clone ccsbBroadEn_07699 GPR83 gene, encodes complete protein.
CU688300 - Synthetic construct Homo sapiens gateway clone IMAGE:100022946 5' read GPR83 mRNA.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q9NYM4 (Reactome details) participates in the following event(s):

R-HSA-744887 Liganded Gs-activating GPCRs bind inactive heterotrimeric Gs
R-HSA-744886 The Ligand:GPCR:Gs complex dissociates
R-HSA-379044 Liganded Gs-activating GPCR acts as a GEF for Gs
R-HSA-418555 G alpha (s) signalling events
R-HSA-388396 GPCR downstream signalling
R-HSA-372790 Signaling by GPCR
R-HSA-162582 Signal Transduction

-  Other Names for This Gene
  Alternate Gene Symbols: B0M0K5, ENST00000243673.1, ENST00000243673.2, ENST00000243673.3, ENST00000243673.4, ENST00000243673.5, ENST00000243673.6, F5GZ43, GPR72 , GPR83 , GPR83_HUMAN, JP05 , KIAA1540 , NM_016540, Q6NWR4, Q9NYM4, Q9P1Y8, uc317emu.1, uc317emu.2
UCSC ID: ENST00000243673.7_7
RefSeq Accession: NM_016540.4
Protein: Q9NYM4 (aka GPR83_HUMAN or GP83_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.