Human Gene GPR87 (ENST00000260843.5_7) from GENCODE V47lift37
  Description: G protein-coupled receptor 87 (from RefSeq NM_023915.4)
Gencode Transcript: ENST00000260843.5_7
Gencode Gene: ENSG00000138271.6_9
Transcript (Including UTRs)
   Position: hg19 chr3:151,011,874-151,034,608 Size: 22,735 Total Exon Count: 3 Strand: -
Coding Region
   Position: hg19 chr3:151,011,957-151,017,888 Size: 5,932 Coding Exon Count: 2 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr3:151,011,874-151,034,608)mRNA (may differ from genome)Protein (358 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
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HGNCMalacardsMGIOMIMPubMedUniProtKB
WikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: GPR87_HUMAN
DESCRIPTION: RecName: Full=G-protein coupled receptor 87; AltName: Full=G-protein coupled receptor 95;
FUNCTION: Receptor for lysophosphatidic acid (LPA). Necessary for p53/TP53-dependent survival in response to DNA damage.
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein (By similarity).
TISSUE SPECIFICITY: Expressed in placenta and prostate. Weaker expression in thymus. Not expressed in thalamus, hippocampus, pons or cerebellum. Overexpressed in squamous cell carcinoma of the lung.
INDUCTION: By expression of p53/TP53 and by DNA damage in a TP53- dependent manner.
SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
SEQUENCE CAUTION: Sequence=AAK29069.1; Type=Erroneous initiation;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: GPR87
Diseases sorted by gene-association score: squamous cell carcinoma (5)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 33.88 RPKM in Esophagus - Mucosa
Total median expression: 142.17 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -85.50333-0.257 Picture PostScript Text
3' UTR -8.2083-0.099 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000276 - 7TM_GPCR_Rhodpsn
IPR017452 - GPCR_Rhodpsn_supfam
IPR002286 - P2_purnocptor
IPR008109 - P2Y13_purnocptor

Pfam Domains:
PF00001 - 7 transmembrane receptor (rhodopsin family)
PF10328 - Serpentine type 7TM GPCR chemoreceptor Srx

SCOP Domains:
81321 - Family A G protein-coupled receptor-like

ModBase Predicted Comparative 3D Structure on Q9BY21
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004871 signal transducer activity
GO:0004930 G-protein coupled receptor activity
GO:0045028 G-protein coupled purinergic nucleotide receptor activity

Biological Process:
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007194 negative regulation of adenylate cyclase activity
GO:0008150 biological_process
GO:0035589 G-protein coupled purinergic nucleotide receptor signaling pathway

Cellular Component:
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  AF345566 - Homo sapiens putative G-protein-coupled receptor FKSG78 (FKSG78) mRNA, complete cds.
AF086432 - Homo sapiens full length insert cDNA clone ZD79H11.
AF237763 - Homo sapiens orphan G protein-coupled receptor 87 (GPR87) mRNA, complete cds.
AB031548 - Homo sapiens KPG_002 mRNA, complete cds.
BC009540 - Homo sapiens G protein-coupled receptor 87, mRNA (cDNA clone IMAGE:3894333), partial cds.
BC112941 - Homo sapiens G protein-coupled receptor 87, mRNA (cDNA clone MGC:131898 IMAGE:4500655), complete cds.
BC117565 - Homo sapiens G protein-coupled receptor 87, mRNA (cDNA clone MGC:131822 IMAGE:4521950), complete cds.
AK027784 - Homo sapiens cDNA FLJ14878 fis, clone PLACE1003238, weakly similar to PROBABLE G PROTEIN-COUPLED RECEPTOR.
BC132888 - Homo sapiens G protein-coupled receptor 87, mRNA (cDNA clone MGC:164519 IMAGE:40146910), complete cds.
BC132890 - Homo sapiens G protein-coupled receptor 87, mRNA (cDNA clone MGC:164521 IMAGE:40146912), complete cds.
AF411114 - Homo sapiens G protein-coupled receptor (GPR95) mRNA, complete cds.
EU883576 - Homo sapiens orphan GPCR 87 (GPR87) mRNA, complete cds.
KJ898959 - Synthetic construct Homo sapiens clone ccsbBroadEn_08353 GPR87 gene, encodes complete protein.
KJ904764 - Synthetic construct Homo sapiens clone ccsbBroadEn_14158 GPR87 gene, encodes complete protein.
HQ258209 - Synthetic construct Homo sapiens clone IMAGE:100072518 G protein-coupled receptor 87 (GPR87) gene, encodes complete protein.
CU679389 - Synthetic construct Homo sapiens gateway clone IMAGE:100018678 5' read GPR87 mRNA.
JD262930 - Sequence 243954 from Patent EP1572962.
JD257511 - Sequence 238535 from Patent EP1572962.
JD056437 - Sequence 37461 from Patent EP1572962.
JD550870 - Sequence 531894 from Patent EP1572962.
JD330705 - Sequence 311729 from Patent EP1572962.
JD507292 - Sequence 488316 from Patent EP1572962.
JD552554 - Sequence 533578 from Patent EP1572962.
JD199136 - Sequence 180160 from Patent EP1572962.
JD296162 - Sequence 277186 from Patent EP1572962.
JD230371 - Sequence 211395 from Patent EP1572962.
JD222035 - Sequence 203059 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000260843.1, ENST00000260843.2, ENST00000260843.3, ENST00000260843.4, FKSG78, GPR87_HUMAN, GPR95, NM_023915, Q5KU35, Q96JZ8, Q9BXC2, Q9BY21, uc317gly.1, uc317gly.2
UCSC ID: ENST00000260843.5_7
RefSeq Accession: NM_023915.4
Protein: Q9BY21 (aka GPR87_HUMAN or GP87_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.