Human Gene GPR88 (ENST00000315033.5_4) from GENCODE V47lift37

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Description: G protein-coupled receptor 88 (from RefSeq NM_022049.3)
Gencode Transcript: ENST00000315033.5_4
Gencode Gene: ENSG00000181656.7_7
Transcript (Including UTRs)
Position: hg19 chr1:101,003,695-101,007,577 Size: 3,883 Total Exon Count: 2 Strand: +
Coding Region
Position: hg19 chr1:101,004,523-101,005,677 Size: 1,155 Coding Exon Count: 1

Page Index	Sequence and Links	UniProtKB Comments	Primers	MalaCards	CTD
Gene Alleles	RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species
GO Annotations	mRNA Descriptions	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr1:101,003,695-101,007,577)			mRNA (may differ from genome)		Protein (384 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	Human Cortex Gene Expression	Malacards	MGI	OMIM	PubMed
UniProtKB	Wikipedia	BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: GPR88_HUMAN DESCRIPTION: RecName: Full=Probable G-protein coupled receptor 88; AltName: Full=Striatum-specific G-protein coupled receptor; FUNCTION: Orphan receptor. SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Expressed almost exclusively in striatum. SIMILARITY: Belongs to the G-protein coupled receptor 1 family.

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

MalaCards Disease Associations


	MalaCards Gene Search: GPR88 Diseases sorted by gene-association score: chorea, childhood-onset, with psychomotor retardation* (969), choreatic disease (4) * = Manually curated disease association

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene C111118 2',3,3',4',5-pentachloro-4-hydroxybiphenyl D016604 Aflatoxin B1 D000643 Ammonium Chloride D001564 Benzo(a)pyrene D003042 Cocaine D016572 Cyclosporine D000431 Ethanol D004997 Ethinyl Estradiol D005419 Flavonoids D009020 Morphine more ... click here to view the complete list

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 51.57 RPKM in Brain - Putamen (basal ganglia) Total median expression: 153.73 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-159.70	437	-0.365	Picture	PostScript	Text
3' UTR	-466.40	1900	-0.245	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR000276 - 7TM_GPCR_Rhodpsn
IPR017452 - GPCR_Rhodpsn_supfam

Pfam Domains:
PF00001 - 7 transmembrane receptor (rhodopsin family)

SCOP Domains:
81321 - Family A G protein-coupled receptor-like
103473 - MFS general substrate transporter

ModBase Predicted Comparative 3D Structure on Q9GZN0


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details
Gene Sorter	Gene Sorter
	RGD

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0003774 motor activity GO:0004871 signal transducer activity GO:0004930 G-protein coupled receptor activity Biological Process: GO:0007165 signal transduction GO:0007186 G-protein coupled receptor signaling pathway GO:0007218 neuropeptide signaling pathway GO:0007268 chemical synaptic transmission GO:0007626 locomotory behavior GO:0007631 feeding behavior GO:0019228 neuronal action potential GO:0050885 neuromuscular process controlling balance GO:0061743 motor learning Cellular Component: GO:0005575 cellular_component GO:0005634 nucleus GO:0005737 cytoplasm GO:0005886 plasma membrane GO:0016020 membrane GO:0016021 integral component of membrane

Descriptions from all associated GenBank mRNAs


	AB042410 - Homo sapiens strg mRNA for striatum-specific G protein-coupled receptor, complete cds. BC036775 - Homo sapiens G protein-coupled receptor 88, mRNA (cDNA clone IMAGE:5729354), partial cds. JD220350 - Sequence 201374 from Patent EP1572962. JD334026 - Sequence 315050 from Patent EP1572962. JD556778 - Sequence 537802 from Patent EP1572962. JD272562 - Sequence 253586 from Patent EP1572962. JD055047 - Sequence 36071 from Patent EP1572962. JD124696 - Sequence 105720 from Patent EP1572962. JD228467 - Sequence 209491 from Patent EP1572962. JD156290 - Sequence 137314 from Patent EP1572962. JD348255 - Sequence 329279 from Patent EP1572962. JD151138 - Sequence 132162 from Patent EP1572962. JD292207 - Sequence 273231 from Patent EP1572962. JD491452 - Sequence 472476 from Patent EP1572962. AK225748 - Homo sapiens mRNA for G-protein coupled receptor 88 variant, clone: FCC135G11. BC172248 - Synthetic construct Homo sapiens clone IMAGE:100068942, MGC:198953 G protein-coupled receptor 88 (GPR88) mRNA, encodes complete protein. JD129634 - Sequence 110658 from Patent EP1572962. JD462961 - Sequence 443985 from Patent EP1572962. JD225924 - Sequence 206948 from Patent EP1572962. JD168936 - Sequence 149960 from Patent EP1572962. JD146381 - Sequence 127405 from Patent EP1572962. JD299953 - Sequence 280977 from Patent EP1572962. JD383023 - Sequence 364047 from Patent EP1572962. JD062976 - Sequence 44000 from Patent EP1572962. JD337127 - Sequence 318151 from Patent EP1572962. JD332889 - Sequence 313913 from Patent EP1572962. JD263292 - Sequence 244316 from Patent EP1572962. JD437593 - Sequence 418617 from Patent EP1572962. JD539466 - Sequence 520490 from Patent EP1572962. AF086060 - Homo sapiens full length insert cDNA clone YZ01B11. JD249359 - Sequence 230383 from Patent EP1572962. JD240537 - Sequence 221561 from Patent EP1572962. JD237740 - Sequence 218764 from Patent EP1572962. JD090043 - Sequence 71067 from Patent EP1572962. JD073109 - Sequence 54133 from Patent EP1572962. JD538871 - Sequence 519895 from Patent EP1572962. JD104107 - Sequence 85131 from Patent EP1572962. JD214997 - Sequence 196021 from Patent EP1572962. JD091347 - Sequence 72371 from Patent EP1572962. JD296352 - Sequence 277376 from Patent EP1572962. JD320526 - Sequence 301550 from Patent EP1572962.

Other Names for This Gene


	Alternate Gene Symbols: ENST00000315033.1, ENST00000315033.2, ENST00000315033.3, ENST00000315033.4, GPR88_HUMAN, NM_022049, Q29S24, Q6VN48, Q9GZN0, STRG, uc317psz.1, uc317psz.2 UCSC ID: ENST00000315033.5_4 RefSeq Accession: NM_022049.3 Protein: Q9GZN0 (aka GPR88_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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