Human Gene GPR88 (ENST00000315033.5_4) from GENCODE V47lift37
  Description: G protein-coupled receptor 88 (from RefSeq NM_022049.3)
Gencode Transcript: ENST00000315033.5_4
Gencode Gene: ENSG00000181656.7_7
Transcript (Including UTRs)
   Position: hg19 chr1:101,003,695-101,007,577 Size: 3,883 Total Exon Count: 2 Strand: +
Coding Region
   Position: hg19 chr1:101,004,523-101,005,677 Size: 1,155 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:101,003,695-101,007,577)mRNA (may differ from genome)Protein (384 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCHuman Cortex Gene ExpressionMalacardsMGIOMIMPubMed
UniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: GPR88_HUMAN
DESCRIPTION: RecName: Full=Probable G-protein coupled receptor 88; AltName: Full=Striatum-specific G-protein coupled receptor;
FUNCTION: Orphan receptor.
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: Expressed almost exclusively in striatum.
SIMILARITY: Belongs to the G-protein coupled receptor 1 family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: GPR88
Diseases sorted by gene-association score: chorea, childhood-onset, with psychomotor retardation* (969), choreatic disease (4)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 51.57 RPKM in Brain - Putamen (basal ganglia)
Total median expression: 153.73 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -159.70437-0.365 Picture PostScript Text
3' UTR -466.401900-0.245 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000276 - 7TM_GPCR_Rhodpsn
IPR017452 - GPCR_Rhodpsn_supfam

Pfam Domains:
PF00001 - 7 transmembrane receptor (rhodopsin family)

SCOP Domains:
81321 - Family A G protein-coupled receptor-like
103473 - MFS general substrate transporter

ModBase Predicted Comparative 3D Structure on Q9GZN0
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003774 motor activity
GO:0004871 signal transducer activity
GO:0004930 G-protein coupled receptor activity

Biological Process:
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007218 neuropeptide signaling pathway
GO:0007268 chemical synaptic transmission
GO:0007626 locomotory behavior
GO:0007631 feeding behavior
GO:0019228 neuronal action potential
GO:0050885 neuromuscular process controlling balance
GO:0061743 motor learning

Cellular Component:
GO:0005575 cellular_component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  AB042410 - Homo sapiens strg mRNA for striatum-specific G protein-coupled receptor, complete cds.
BC036775 - Homo sapiens G protein-coupled receptor 88, mRNA (cDNA clone IMAGE:5729354), partial cds.
JD220350 - Sequence 201374 from Patent EP1572962.
JD334026 - Sequence 315050 from Patent EP1572962.
JD556778 - Sequence 537802 from Patent EP1572962.
JD272562 - Sequence 253586 from Patent EP1572962.
JD055047 - Sequence 36071 from Patent EP1572962.
JD124696 - Sequence 105720 from Patent EP1572962.
JD228467 - Sequence 209491 from Patent EP1572962.
JD156290 - Sequence 137314 from Patent EP1572962.
JD348255 - Sequence 329279 from Patent EP1572962.
JD151138 - Sequence 132162 from Patent EP1572962.
JD292207 - Sequence 273231 from Patent EP1572962.
JD491452 - Sequence 472476 from Patent EP1572962.
AK225748 - Homo sapiens mRNA for G-protein coupled receptor 88 variant, clone: FCC135G11.
BC172248 - Synthetic construct Homo sapiens clone IMAGE:100068942, MGC:198953 G protein-coupled receptor 88 (GPR88) mRNA, encodes complete protein.
JD129634 - Sequence 110658 from Patent EP1572962.
JD462961 - Sequence 443985 from Patent EP1572962.
JD225924 - Sequence 206948 from Patent EP1572962.
JD168936 - Sequence 149960 from Patent EP1572962.
JD146381 - Sequence 127405 from Patent EP1572962.
JD299953 - Sequence 280977 from Patent EP1572962.
JD383023 - Sequence 364047 from Patent EP1572962.
JD062976 - Sequence 44000 from Patent EP1572962.
JD337127 - Sequence 318151 from Patent EP1572962.
JD332889 - Sequence 313913 from Patent EP1572962.
JD263292 - Sequence 244316 from Patent EP1572962.
JD437593 - Sequence 418617 from Patent EP1572962.
JD539466 - Sequence 520490 from Patent EP1572962.
AF086060 - Homo sapiens full length insert cDNA clone YZ01B11.
JD249359 - Sequence 230383 from Patent EP1572962.
JD240537 - Sequence 221561 from Patent EP1572962.
JD237740 - Sequence 218764 from Patent EP1572962.
JD090043 - Sequence 71067 from Patent EP1572962.
JD073109 - Sequence 54133 from Patent EP1572962.
JD538871 - Sequence 519895 from Patent EP1572962.
JD104107 - Sequence 85131 from Patent EP1572962.
JD214997 - Sequence 196021 from Patent EP1572962.
JD091347 - Sequence 72371 from Patent EP1572962.
JD296352 - Sequence 277376 from Patent EP1572962.
JD320526 - Sequence 301550 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000315033.1, ENST00000315033.2, ENST00000315033.3, ENST00000315033.4, GPR88_HUMAN, NM_022049, Q29S24, Q6VN48, Q9GZN0, STRG, uc317psz.1, uc317psz.2
UCSC ID: ENST00000315033.5_4
RefSeq Accession: NM_022049.3
Protein: Q9GZN0 (aka GPR88_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.