ID:GASP1_HUMAN DESCRIPTION: RecName: Full=G-protein coupled receptor-associated sorting protein 1; Short=GASP-1; FUNCTION: May modulate lysosomal sorting and functional down- regulation of a variety of G-protein coupled receptors. Targets receptors for degradation in lysosomes. SUBUNIT: Interacts with cytoplasmic tails of a variety of G- protein coupled receptors such as D2 dopamine receptor/DRD2 (By similarity), delta opioid receptor/OPRD1, beta-2 adrenergic receptor/ADRB2 and D4 dopamine receptor/DRD4. Interacts with PER1. INTERACTION: P41143:OPRD1; NbExp=2; IntAct=EBI-2514717, EBI-2624456; SUBCELLULAR LOCATION: Cytoplasm. TISSUE SPECIFICITY: Expressed in the brain, with lower expression in medulla, spinal cord and substantia nigra. SIMILARITY: Belongs to the GPRASP family. SEQUENCE CAUTION: Sequence=BAA23715.3; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q5JY77
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
