Human Gene GPRC5A (ENST00000014914.6_7) from GENCODE V47lift37
Description: G protein-coupled receptor class C group 5 member A (from RefSeq NM_003979.4)Gencode Transcript: ENST00000014914.6_7Gencode Gene: ENSG00000013588.10_13Transcript (Including UTRs) Position: hg19 chr12:13,044,496-13,070,871 Size: 26,376 Total Exon Count: 4 Strand: +Coding Region Position: hg19 chr12:13,061,184-13,065,473 Size: 4,290 Coding Exon Count: 3
Data last updated at UCSC: 2024-08-22 23:36:26
Sequence and Links to Tools and Databases
Comments and Description Text from UniProtKB
ID: RAI3_HUMAN DESCRIPTION: RecName: Full=Retinoic acid-induced protein 3; AltName: Full=G-protein coupled receptor family C group 5 member A; AltName: Full=Orphan G-protein-coupling receptor PEIG-1; AltName: Full=Retinoic acid-induced gene 1 protein; Short=RAIG-1;FUNCTION: Unknown. This G-protein coupled receptor could be involved in modulating differentiation and maintaining homeostasis of epithelial cells. The comparable expression level in fetal lung and kidney with adult tissues suggests a possible role in embryonic development and maturation of these organs. This retinoic acid-inducible GPCR provide evidence for a possible interaction between retinoid and G-protein signaling pathways.SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Note=Localized in the plasma membrane and perinuclear vesicles.TISSUE SPECIFICITY: Expressed at high level in fetal and adult lung tissues. Constitutively expressed in fetal kidney and adult placenta, kidney, prostate, testis, ovary, small intestine, colon, stomach, and spinal chord at low to moderate levels. Not detectable in fetal heart, brain, and liver and adult heart, brain, liver, skeletal muscle, pancreas, spleen, thymus, and peripheral leukocytes. According to PubMed:10783259, expressed at low but detectable level in pancreas and heart.INDUCTION: By all-trans retinoic acid (ATRA).SIMILARITY: Belongs to the G-protein coupled receptor 3 family.
Primer design for this transcript
MalaCards Disease Associations
MalaCards Gene Search: GPRC5A
Diseases sorted by gene-association score: lung cancer (2)
Comparative Toxicogenomics Database (CTD)
Common Gene Haplotype Alleles
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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR017978 - GPCR_3_CPfam Domains: PF00003 - 7 transmembrane sweet-taste receptor of 3 GCPRModBase Predicted Comparative 3D Structure on Q8NFJ5 The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Descriptions from all associated GenBank mRNAs
AK122672 - Homo sapiens cDNA FLJ16117 fis, clone ASTRO2003632, highly similar to Retinoic acid-induced protein 3 (G-proteincoupled receptor family C group 5 member A).LF384198 - JP 2014500723-A/191701: Polycomb-Associated Non-Coding RNAs.AK001761 - Homo sapiens cDNA FLJ10899 fis, clone NT2RP5003506.JD251099 - Sequence 232123 from Patent EP1572962.AF095448 - Homo sapiens putative G protein-coupled receptor (RAIG1) mRNA, complete cds.BC003665 - Homo sapiens G protein-coupled receptor, family C, group 5, member A, mRNA (cDNA clone MGC:923 IMAGE:2988011), complete cds.JD387196 - Sequence 368220 from Patent EP1572962.AK291171 - Homo sapiens cDNA FLJ78217 complete cds.AB590795 - Synthetic construct DNA, clone: pFN21AE1136, Homo sapiens GPRC5A gene for G protein-coupled receptor, family C, group 5, member A, without stop codon, in Flexi system.LF366121 - JP 2014500723-A/173624: Polycomb-Associated Non-Coding RNAs.AK172760 - Homo sapiens cDNA FLJ23921 fis, clone COL02043, highly similar to Homo sapiens retinoic acid induced 3 (RAI3).LF366122 - JP 2014500723-A/173625: Polycomb-Associated Non-Coding RNAs.LF366123 - JP 2014500723-A/173626: Polycomb-Associated Non-Coding RNAs.LF366124 - JP 2014500723-A/173627: Polycomb-Associated Non-Coding RNAs.LF366125 - JP 2014500723-A/173628: Polycomb-Associated Non-Coding RNAs.LF366126 - JP 2014500723-A/173629: Polycomb-Associated Non-Coding RNAs.LF366127 - JP 2014500723-A/173630: Polycomb-Associated Non-Coding RNAs.JD041804 - Sequence 22828 from Patent EP1572962.JD168855 - Sequence 149879 from Patent EP1572962.JD040354 - Sequence 21378 from Patent EP1572962.JD358632 - Sequence 339656 from Patent EP1572962.JD263380 - Sequence 244404 from Patent EP1572962.JD263381 - Sequence 244405 from Patent EP1572962.JD431855 - Sequence 412879 from Patent EP1572962.JD272021 - Sequence 253045 from Patent EP1572962.JD198369 - Sequence 179393 from Patent EP1572962.JD153081 - Sequence 134105 from Patent EP1572962.JD160934 - Sequence 141958 from Patent EP1572962.JD160935 - Sequence 141959 from Patent EP1572962.JD281492 - Sequence 262516 from Patent EP1572962.JD281493 - Sequence 262517 from Patent EP1572962.JD492097 - Sequence 473121 from Patent EP1572962.JD513661 - Sequence 494685 from Patent EP1572962.JD389021 - Sequence 370045 from Patent EP1572962.JD389022 - Sequence 370046 from Patent EP1572962.JD081166 - Sequence 62190 from Patent EP1572962.JD525259 - Sequence 506283 from Patent EP1572962.JD251521 - Sequence 232545 from Patent EP1572962.JD376640 - Sequence 357664 from Patent EP1572962.JD069742 - Sequence 50766 from Patent EP1572962.JD069741 - Sequence 50765 from Patent EP1572962.JD172891 - Sequence 153915 from Patent EP1572962.JD406295 - Sequence 387319 from Patent EP1572962.JD414838 - Sequence 395862 from Patent EP1572962.JD476735 - Sequence 457759 from Patent EP1572962.JD414837 - Sequence 395861 from Patent EP1572962.JD379689 - Sequence 360713 from Patent EP1572962.JD311819 - Sequence 292843 from Patent EP1572962.JD311820 - Sequence 292844 from Patent EP1572962.JD081615 - Sequence 62639 from Patent EP1572962.JD087844 - Sequence 68868 from Patent EP1572962.JD438259 - Sequence 419283 from Patent EP1572962.JD143790 - Sequence 124814 from Patent EP1572962.JD048364 - Sequence 29388 from Patent EP1572962.JD421233 - Sequence 402257 from Patent EP1572962.JD209932 - Sequence 190956 from Patent EP1572962.JD359908 - Sequence 340932 from Patent EP1572962.LF366128 - JP 2014500723-A/173631: Polycomb-Associated Non-Coding RNAs.JD042085 - Sequence 23109 from Patent EP1572962.JD054659 - Sequence 35683 from Patent EP1572962.JD259160 - Sequence 240184 from Patent EP1572962.JD200399 - Sequence 181423 from Patent EP1572962.LF366129 - JP 2014500723-A/173632: Polycomb-Associated Non-Coding RNAs.JD132913 - Sequence 113937 from Patent EP1572962.JD507940 - Sequence 488964 from Patent EP1572962.JD447762 - Sequence 428786 from Patent EP1572962.JD259209 - Sequence 240233 from Patent EP1572962.JD240403 - Sequence 221427 from Patent EP1572962.BC042436 - Homo sapiens cDNA clone IMAGE:4471726, partial cds.AB462503 - Homo sapiens TVAS4 mRNA, PBMC-based diagnostic gene marker for vasculitis.AK055564 - Homo sapiens cDNA FLJ31002 fis, clone HLUNG2000004.BC028047 - Homo sapiens cDNA clone IMAGE:3899689, partial cds.BC016955 - Homo sapiens cDNA clone IMAGE:3899737, partial cds.BC052267 - Homo sapiens cDNA clone IMAGE:6575745, partial cds.BC062343 - Homo sapiens cDNA clone IMAGE:6574112, partial cds.BC039736 - Homo sapiens cDNA clone IMAGE:6025865, partial cds.JD365052 - Sequence 346076 from Patent EP1572962.DM176579 - A nucleics Acid regulating cell growth.HZ408692 - JP 2015528002-A/1289: CHIRAL CONTROL.HZ460865 - WO 2015190584-A/362: Kit or device and method for detecting prostate cancer.HZ461530 - WO 2015190586-A/343: Kit and method for detecting colon cancer.HZ462241 - WO 2015190591-A/396: Kit and method for detecting breast cancer.HZ463200 - WO 2015194535-A/294: Kit and method for detecting stomach cancer.HZ463868 - WO 2015194610-A/304: Kit and method for detecting lung cancer.HZ464571 - WO 2015194615-A/389: Kit or device and method for detecting hepatic cancer.HZ465344 - WO 2015194627-A/397: Kit and method for detecting esophageal cancer.LG052026 - KR 1020150036642-A/1292: CHIRAL CONTROL.LY496527 - KR 1020170018406-A/397: ESOPHAGEAL CANCER DETECTION KIT OR DEVICE, AND DETECTION METHOD.LY497173 - KR 1020170016485-A/343: COLORECTAL CANCER DETECTION KIT OR DEVICE, AND DETECTION METHOD.LY497769 - KR 1020170018409-A/304: KIT OR DEVICE FOR DETECTING LUNG CANCER, AND LUNG CANCER DETECTION METHOD.LY498472 - KR 1020170018411-A/389: LIVER CANCER DETECTION KIT OR DEVICE, AND DETECTION METHOD.LY499244 - KR 1020170018412-A/396: BREAST CANCER DETECTION KIT OR DEVICE, AND METHOD FOR DETECTING BREAST CANCER.LY500013 - KR 1020170019425-A/294: STOMACH CANCER DETECTION KIT OR DEVICE, AND DETECTION METHOD.LY500738 - KR 1020170016490-A/362: PROSTATE CANCER DETECTION KIT OR DEVICE, AND DETECTION METHOD.LZ238639 - WO 2017171048-A/300: Kit, device and method for detecting early pancreatic cancer or precancerous lesion of pancreas.MS869657 - Sequence 362 from Patent EP3156483.MS880559 - Sequence 396 from Patent EP3156498.MS884360 - Sequence 343 from Patent EP3156499.MS885132 - Sequence 294 from Patent EP3156503.MS994535 - Sequence 397 from Patent EP3159406.MS996835 - Sequence 304 from Patent EP3159416.DM176499 - A nucleics Acid regulating cell growth.FW312374 - DETECTING NUCLEIC ACIDS.FW364520 - Oligonucleotides for modulating target RNA activity.HI964860 - Sequence 145 from Patent WO2010139812.HI966456 - Sequence 776 from Patent WO2010139811.HI967322 - Sequence 776 from Patent WO2010139810.HV595432 - JP 2010539959-A/813: Micromirs.HV953983 - JP 2012518421-A/895: METHODS OF DETECTING LUNG CANCER.HZ074470 - JP 2013535982-A/561: Single-Stranded RNAi Agents Containing an Internal, Non-Nucleic Acid Spacer.HZ157989 - JP 2015130862-A/813: Micromirs.HZ186833 - JP 2015146814-A/582: Oligonucleotides for modulating target RNA activity.HZ460681 - WO 2015190584-A/178: Kit or device and method for detecting prostate cancer.HZ461338 - WO 2015190586-A/151: Kit and method for detecting colon cancer.HZ461963 - WO 2015190591-A/118: Kit and method for detecting breast cancer.HZ463001 - WO 2015194535-A/95: Kit and method for detecting stomach cancer.HZ463689 - WO 2015194610-A/125: Kit and method for detecting lung cancer.HZ464354 - WO 2015194615-A/172: Kit or device and method for detecting hepatic cancer.HZ465134 - WO 2015194627-A/187: Kit and method for detecting esophageal cancer.HZ482444 - JP 2015535430-A/2950: TERMINALLY MODIFIED RNA.HZ792375 - JP 2016504050-A/4120: SIGNAL-SENSOR POLYNUCLEOTIDES FOR THE ALTERATION OF CELLULAR PHENOTYPES.JA400898 - Sequence 145 from Patent WO2011080318.JA401876 - Sequence 145 from Patent WO2011080315.JA402883 - Sequence 145 from Patent WO2011080316.JA405514 - Sequence 145 from Patent EP2336353.JA426934 - Sequence 267 from Patent WO2011072177.JA429040 - Sequence 145 from Patent WO2011095623.JA715113 - Sequence 895 from Patent EP2401406.JA792027 - Sequence 76 from Patent WO2012089753.JA808545 - Sequence 17 from Patent WO2012083969.JB620655 - Sequence 635 from Patent WO2013063544.JC515107 - Sequence 5360 from Patent WO2014113089.LF160840 - JP 2016513950-A/906: Oligomers with improved off-target profile.LP727082 - Sequence 776 from Patent EP2883966.LP819352 - Sequence 776 from Patent EP3296406.LP939294 - Sequence 776 from Patent EP3184651.LQ072695 - Sequence 3019 from Patent EP2964234.LY405497 - KR 1020160117535-A/802: POLY OLIGOMER COMPOUND WITH BIOCLEAVABLE CONJUGATES.LY496317 - KR 1020170018406-A/187: ESOPHAGEAL CANCER DETECTION KIT OR DEVICE, AND DETECTION METHOD.LY496981 - KR 1020170016485-A/151: COLORECTAL CANCER DETECTION KIT OR DEVICE, AND DETECTION METHOD.LY497590 - KR 1020170018409-A/125: KIT OR DEVICE FOR DETECTING LUNG CANCER, AND LUNG CANCER DETECTION METHOD.LY498255 - KR 1020170018411-A/172: LIVER CANCER DETECTION KIT OR DEVICE, AND DETECTION METHOD.LY498966 - KR 1020170018412-A/118: BREAST CANCER DETECTION KIT OR DEVICE, AND METHOD FOR DETECTING BREAST CANCER.LY499814 - KR 1020170019425-A/95: STOMACH CANCER DETECTION KIT OR DEVICE, AND DETECTION METHOD.LY500554 - KR 1020170016490-A/178: PROSTATE CANCER DETECTION KIT OR DEVICE, AND DETECTION METHOD.LZ234190 - JP 2017184756-A/582: Oligonucleotides for modulating target RNA activity.LZ238388 - WO 2017171048-A/49: Kit, device and method for detecting early pancreatic cancer or precancerous lesion of pancreas.MA260736 - JP 2017505623-A/802: POLY OLIGOMER COMPOUND WITH BIOCLEAVABLE CONJUGATES.MS833999 - Sequence 145 from Patent EP3112479.MS869473 - Sequence 178 from Patent EP3156483.MS880281 - Sequence 118 from Patent EP3156498.MS884168 - Sequence 151 from Patent EP3156499.MS884933 - Sequence 95 from Patent EP3156503.MS994325 - Sequence 187 from Patent EP3159406.MS996656 - Sequence 125 from Patent EP3159416.AK025835 - Homo sapiens cDNA: FLJ22182 fis, clone HRC00953.MA646196 - JP 2017113010-A/4120: SIGNAL-SENSOR POLYNUCLEOTIDES FOR THE ALTERATION OF CELLULAR PHENOTYPES.MA734080 - JP 2017140048-A/2950: TERMINALLY MODIFIED RNA.MA619775 - JP 2018138019-A/191701: Polycomb-Associated Non-Coding RNAs.MA601698 - JP 2018138019-A/173624: Polycomb-Associated Non-Coding RNAs.MA601699 - JP 2018138019-A/173625: Polycomb-Associated Non-Coding RNAs.MA601700 - JP 2018138019-A/173626: Polycomb-Associated Non-Coding RNAs.MA601701 - JP 2018138019-A/173627: Polycomb-Associated Non-Coding RNAs.MA601702 - JP 2018138019-A/173628: Polycomb-Associated Non-Coding RNAs.MA601703 - JP 2018138019-A/173629: Polycomb-Associated Non-Coding RNAs.MA601704 - JP 2018138019-A/173630: Polycomb-Associated Non-Coding RNAs.MA601705 - JP 2018138019-A/173631: Polycomb-Associated Non-Coding RNAs.MA601706 - JP 2018138019-A/173632: Polycomb-Associated Non-Coding RNAs.MP015056 - Sequence 259 from Patent WO2019016252.MA806087 - WO 2018199275-A/347: Kit, device and method for detection of ovary tumor.MA803249 - JP 2018183181-A/4120: SIGNAL-SENSOR POLYNUCLEOTIDES FOR THE ALTERATION OF CELLULAR PHENOTYPES.MA805809 - WO 2018199275-A/69: Kit, device and method for detection of ovary tumor.MA822781 - WO 2019004436-A/594: Kit, device, and method for detection of lung cancer.MA822442 - WO 2019004436-A/255: Kit, device, and method for detection of lung cancer.MB021436 - JP 2019050772-A/7: A test method for predicting side reactions after vaccination.LY616403 - KR 1020180129785-A/300: KIT OR DEVICE FOR DETECTING EARLY STAGE PANCREATIC CANCER OR PANCREATIC CANCER PRECURSOR LESIONS AND DETECTION METHOD THEREFOR.LY616152 - KR 1020180129785-A/49: KIT OR DEVICE FOR DETECTING EARLY STAGE PANCREATIC CANCER OR PANCREATIC CANCER PRECURSOR LESIONS AND DETECTION METHOD THEREFOR.AF506289 - Homo sapiens orphan G protein-coupling receptor PEIG-1 mRNA, complete cds.MB472988 - WO 2019208671-A/387: Kit or device and method for detecting bladder cancer.MB472755 - WO 2019208671-A/154: Kit or device and method for detecting bladder cancer.
Other Names for This Gene
Alternate Gene Symbols: B3KV45, ENST00000014914.1, ENST00000014914.2, ENST00000014914.3, ENST00000014914.4, ENST00000014914.5, GPCR5A, NM_003979, O95357, Q8NFJ5, RAI3, RAI3_HUMAN, RAIG1, uc317bxx.1, uc317bxx.2UCSC ID: ENST00000014914.6_7RefSeq Accession: NM_003979.4 Protein: Q8NFJ5
(aka RAI3_HUMAN)
Gene Model Information
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for a detailed description of the fields of the table above.
Methods, Credits, and Use Restrictions
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for details on how this gene model was made and data restrictions if any.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
