Human Gene GPS2 (ENST00000380728.7_7) from GENCODE V47lift37
  Description: G protein pathway suppressor 2 (from RefSeq NM_004489.5)
Gencode Transcript: ENST00000380728.7_7
Gencode Gene: ENSG00000132522.16_16
Transcript (Including UTRs)
   Position: hg19 chr17:7,215,980-7,218,679 Size: 2,700 Total Exon Count: 11 Strand: -
Coding Region
   Position: hg19 chr17:7,216,075-7,218,371 Size: 2,297 Coding Exon Count: 10 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr17:7,215,980-7,218,679)mRNA (may differ from genome)Protein (327 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedReactome
UniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: GPS2_HUMAN
DESCRIPTION: RecName: Full=G protein pathway suppressor 2; Short=GPS-2;
FUNCTION: Suppresses G-protein- and mitogen-activated protein kinase-mediated signal transduction.
SUBUNIT: Component of the N-Cor repressor complex, at least composed of NCOR1, NCOR2, HDAC3, TBL1X, TBL1R, CORO2A and GPS2.
INTERACTION: P57077:TAK1L; NbExp=2; IntAct=EBI-713355, EBI-748831; P12504:vif (xeno); NbExp=2; IntAct=EBI-713355, EBI-779991;
TISSUE SPECIFICITY: Widely expressed.
SEQUENCE CAUTION: Sequence=CAB75677.2; Type=Erroneous translation; Note=Wrong choice of frame;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: GPS2
Diseases sorted by gene-association score: timothy grass allergy (3)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
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+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -39.5097-0.407 Picture PostScript Text
3' UTR -20.8095-0.219 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR026094 - GPS2

Pfam Domains:
PF15991 - G-protein pathway suppressor

Protein Data Bank (PDB) 3-D Structure
MuPIT help
2L5G - NMR MuPIT


ModBase Predicted Comparative 3D Structure on Q13227
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGDEnsembl   
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003713 transcription coactivator activity
GO:0003714 transcription corepressor activity
GO:0005095 GTPase inhibitor activity
GO:0005515 protein binding
GO:0030332 cyclin binding

Biological Process:
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0000188 inactivation of MAPK activity
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007254 JNK cascade
GO:0010804 negative regulation of tumor necrosis factor-mediated signaling pathway
GO:0010875 positive regulation of cholesterol efflux
GO:0016032 viral process
GO:0019216 regulation of lipid metabolic process
GO:0030183 B cell differentiation
GO:0034122 negative regulation of toll-like receptor signaling pathway
GO:0034260 negative regulation of GTPase activity
GO:0035360 positive regulation of peroxisome proliferator activated receptor signaling pathway
GO:0045598 regulation of fat cell differentiation
GO:0045599 negative regulation of fat cell differentiation
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0046329 negative regulation of JNK cascade
GO:0050728 negative regulation of inflammatory response
GO:0050859 negative regulation of B cell receptor signaling pathway
GO:0098780 response to mitochondrial depolarisation
GO:1900045 negative regulation of protein K63-linked ubiquitination

Cellular Component:
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0017053 transcriptional repressor complex


-  Descriptions from all associated GenBank mRNAs
  LF209156 - JP 2014500723-A/16659: Polycomb-Associated Non-Coding RNAs.
AK301877 - Homo sapiens cDNA FLJ61446 complete cds, highly similar to G protein pathway suppressor 2.
BC014192 - Homo sapiens G protein pathway suppressor 2, mRNA (cDNA clone IMAGE:4761870), with apparent retained intron.
BC013652 - Homo sapiens G protein pathway suppressor 2, mRNA (cDNA clone IMAGE:3461822), complete cds.
AL122080 - Homo sapiens mRNA; cDNA DKFZp434L1550 (from clone DKFZp434L1550).
AL157493 - Homo sapiens mRNA; cDNA DKFZp434A0312 (from clone DKFZp434A0312).
AK092999 - Homo sapiens cDNA FLJ35680 fis, clone SPLEN2019043.
AX747847 - Sequence 1372 from Patent EP1308459.
BC107738 - Homo sapiens G protein pathway suppressor 2, mRNA (cDNA clone MGC:104294 IMAGE:5810755), complete cds.
U28963 - Human Gps2 (GPS2) mRNA, complete cds.
BC103901 - Homo sapiens G protein pathway suppressor 2, mRNA (cDNA clone MGC:119287 IMAGE:40005162), complete cds.
BC103902 - Homo sapiens G protein pathway suppressor 2, mRNA (cDNA clone IMAGE:40005169), complete cds.
BC103903 - Homo sapiens G protein pathway suppressor 2, mRNA (cDNA clone MGC:119289 IMAGE:40005170), complete cds.
KJ891290 - Synthetic construct Homo sapiens clone ccsbBroadEn_00684 GPS2 gene, encodes complete protein.
CR541723 - Homo sapiens full open reading frame cDNA clone RZPDo834B0929D for gene GPS2, G protein pathway suppressor 2; complete cds, incl. stopcodon.
KJ938048 - Homo sapiens MLL4/GPS2 fusion protein mRNA, complete cds.
BT006998 - Homo sapiens G protein pathway suppressor 2 mRNA, complete cds.
CR541750 - Homo sapiens full open reading frame cDNA clone RZPDo834G0929D for gene GPS2, G protein pathway suppressor 2; complete cds, without stopcodon.
LF326456 - JP 2014500723-A/133959: Polycomb-Associated Non-Coding RNAs.
JD405573 - Sequence 386597 from Patent EP1572962.
MA562033 - JP 2018138019-A/133959: Polycomb-Associated Non-Coding RNAs.
MA444733 - JP 2018138019-A/16659: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q13227 (Reactome details) participates in the following event(s):

R-HSA-3777129 HDAC3 containing complexes deacetylate histone
R-HSA-3214815 HDACs deacetylate histones
R-HSA-3247509 Chromatin modifying enzymes
R-HSA-4839726 Chromatin organization

-  Other Names for This Gene
  Alternate Gene Symbols: B4DXA1, ENST00000380728.1, ENST00000380728.2, ENST00000380728.3, ENST00000380728.4, ENST00000380728.5, ENST00000380728.6, GPS2 , GPS2_HUMAN, NM_004489, Q13227, Q6FHM8, uc318puk.1, uc318puk.2
UCSC ID: ENST00000380728.7_7
RefSeq Accession: NM_004489.5
Protein: Q13227 (aka GPS2_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.