Human Gene GPX2 (ENST00000389614.6_9) from GENCODE V47lift37
  Description: glutathione peroxidase 2, transcript variant 1 (from RefSeq NM_002083.4)
Gencode Transcript: ENST00000389614.6_9
Gencode Gene: ENSG00000176153.13_10
Transcript (Including UTRs)
   Position: hg19 chr14:65,405,876-65,409,463 Size: 3,588 Total Exon Count: 2 Strand: -
Coding Region
   Position: hg19 chr14:65,406,206-65,409,444 Size: 3,239 Coding Exon Count: 2 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr14:65,405,876-65,409,463)mRNA (may differ from genome)Protein (190 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedReactome
UniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: GPX2_HUMAN
DESCRIPTION: RecName: Full=Glutathione peroxidase 2; Short=GPx-2; Short=GSHPx-2; EC=1.11.1.9; AltName: Full=Gastrointestinal glutathione peroxidase; AltName: Full=Glutathione peroxidase-gastrointestinal; Short=GPx-GI; Short=GSHPx-GI; AltName: Full=Glutathione peroxidase-related protein 2; Short=GPRP-2;
FUNCTION: Could play a major role in protecting mammals from the toxicity of ingested organic hydroperoxides. Tert-butyl hydroperoxide, cumene hydroperoxide and linoleic acid hydroperoxide but not phosphatidycholine hydroperoxide, can act as acceptors.
CATALYTIC ACTIVITY: 2 glutathione + H(2)O(2) = glutathione disulfide + 2 H(2)O.
SUBUNIT: Homotetramer.
SUBCELLULAR LOCATION: Cytoplasm. Note=Mainly cytoplasmic.
TISSUE SPECIFICITY: Mostly in liver and gastrointestinal tract, not found in heart or kidney.
SIMILARITY: Belongs to the glutathione peroxidase family.
WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/gpx2/";

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: GPX2
Diseases sorted by gene-association score: colorectal cancer (3)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 151.49 RPKM in Liver
Total median expression: 675.05 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -1.2019-0.063 Picture PostScript Text
3' UTR -105.80330-0.321 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000889 - Glutathione_peroxidase
IPR012336 - Thioredoxin-like_fold

Pfam Domains:
PF00255 - Glutathione peroxidase

SCOP Domains:
52833 - Thioredoxin-like

Protein Data Bank (PDB) 3-D Structure
MuPIT help
2HE3 - X-ray MuPIT


ModBase Predicted Comparative 3D Structure on P18283
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004601 peroxidase activity
GO:0004602 glutathione peroxidase activity
GO:0009055 electron carrier activity
GO:0016491 oxidoreductase activity

Biological Process:
GO:0006979 response to oxidative stress
GO:0022900 electron transport chain
GO:0034599 cellular response to oxidative stress
GO:0055114 oxidation-reduction process
GO:0098869 cellular oxidant detoxification

Cellular Component:
GO:0005737 cytoplasm
GO:0005829 cytosol


-  Descriptions from all associated GenBank mRNAs
  BC022820 - Homo sapiens glutathione peroxidase 2 (gastrointestinal), mRNA (cDNA clone MGC:39263 IMAGE:5429926), complete cds.
AK225871 - Homo sapiens mRNA for gastrointestinal glutathione peroxidase 2 variant, clone: FCC124C06.
BC067221 - Homo sapiens glutathione peroxidase 2 (gastrointestinal), mRNA (cDNA clone MGC:71978 IMAGE:6668339), complete cds.
X68314 - H.sapiens mRNA for glutathione peroxidase-GI.
BC005277 - Homo sapiens glutathione peroxidase 2 (gastrointestinal), mRNA (cDNA clone MGC:12324 IMAGE:3996732), complete cds.
BC016756 - Homo sapiens glutathione peroxidase 2 (gastrointestinal), mRNA (cDNA clone MGC:13627 IMAGE:3681457), complete cds.
X53463 - Human mRNA for glutathione peroxidase-like protein.
BC039850 - Homo sapiens cDNA clone IMAGE:5761158, containing frame-shift errors.
BC046164 - Homo sapiens cDNA clone IMAGE:5182669, containing frame-shift errors.
JD502438 - Sequence 483462 from Patent EP1572962.
JD235643 - Sequence 216667 from Patent EP1572962.
JD428653 - Sequence 409677 from Patent EP1572962.
JD195519 - Sequence 176543 from Patent EP1572962.
JD443828 - Sequence 424852 from Patent EP1572962.
JD079730 - Sequence 60754 from Patent EP1572962.
JD267250 - Sequence 248274 from Patent EP1572962.
JD113457 - Sequence 94481 from Patent EP1572962.
JD470738 - Sequence 451762 from Patent EP1572962.
JD324865 - Sequence 305889 from Patent EP1572962.
JD525749 - Sequence 506773 from Patent EP1572962.
JD412241 - Sequence 393265 from Patent EP1572962.
JD548763 - Sequence 529787 from Patent EP1572962.
KJ896929 - Synthetic construct Homo sapiens clone ccsbBroadEn_06323 GPX2-like gene, encodes complete protein.
E02175 - Human glutathione peroxidase gene.

-  Biochemical and Signaling Pathways
  BioCyc Knowledge Library
DETOX1-PWY-1 - reactive oxygen species degradation
PWY-4081 - glutathione-peroxide redox reactions

Reactome (by CSHL, EBI, and GO)

Protein P18283 (Reactome details) participates in the following event(s):

R-HSA-3341277 GPX2 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O
R-HSA-2161791 15S-HpETE is reduced to 15S-HETE by GPX1/2/4
R-HSA-2161946 5S-HpETE is reduced to 5S-HETE by GPX1/2/4
R-HSA-2161959 12R-HpETE is reduced to 12R-HETE by GPX1/2/4
R-HSA-2161999 12S-HpETE is reduced to 12S-HETE by GPX1/2/4
R-HSA-3299685 Detoxification of Reactive Oxygen Species
R-HSA-5628897 TP53 Regulates Metabolic Genes
R-HSA-2142770 Synthesis of 15-eicosatetraenoic acid derivatives
R-HSA-2142688 Synthesis of 5-eicosatetraenoic acids
R-HSA-2142712 Synthesis of 12-eicosatetraenoic acid derivatives
R-HSA-2262752 Cellular responses to stress
R-HSA-3700989 Transcriptional Regulation by TP53
R-HSA-2142753 Arachidonic acid metabolism
R-HSA-8953897 Cellular responses to external stimuli
R-HSA-212436 Generic Transcription Pathway
R-HSA-8978868 Fatty acid metabolism
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-556833 Metabolism of lipids
R-HSA-74160 Gene expression (Transcription)
R-HSA-1430728 Metabolism

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000389614.1, ENST00000389614.2, ENST00000389614.3, ENST00000389614.4, ENST00000389614.5, GPX2 , GPX2_HUMAN, NM_002083, P18283, Q6PJ52, Q8WWI7, Q9NRP9, uc318tgh.1, uc318tgh.2
UCSC ID: ENST00000389614.6_9
RefSeq Accession: NM_002083.4
Protein: P18283 (aka GPX2_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.