Human Gene GPX5 (ENST00000412168.7_4) from GENCODE V47lift37
  Description: glutathione peroxidase 5, transcript variant 1 (from RefSeq NM_001509.3)
Gencode Transcript: ENST00000412168.7_4
Gencode Gene: ENSG00000224586.7_7
Transcript (Including UTRs)
   Position: hg19 chr6:28,493,658-28,502,732 Size: 9,075 Total Exon Count: 5 Strand: +
Coding Region
   Position: hg19 chr6:28,493,791-28,501,944 Size: 8,154 Coding Exon Count: 5 

Page IndexSequence and LinksPrimersCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureOther SpeciesmRNA DescriptionsPathwaysOther Names
Model InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr6:28,493,658-28,502,732)mRNA (may differ from genome)Protein (221 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMGIOMIMPubMedUniProtKBWikipedia
BioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 2.60 RPKM in Testis
Total median expression: 2.60 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -44.30133-0.333 Picture PostScript Text
3' UTR -208.00788-0.264 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologGenome BrowserNo ortholog
Gene DetailsGene Details  Gene Details 
Gene SorterGene Sorter  Gene Sorter 
 RGD  WormBase 
    Protein Sequence 
    Alignment 

-  Descriptions from all associated GenBank mRNAs
  BC128159 - Homo sapiens glutathione peroxidase 5 (epididymal androgen-related protein), mRNA (cDNA clone IMAGE:40112992), complete cds.
BC128160 - Homo sapiens glutathione peroxidase 5 (epididymal androgen-related protein), mRNA (cDNA clone IMAGE:40113000), complete cds.
AJ005277 - Homo sapiens mRNA for glutathione peroxidase type 5 (GPX5).
FJ460514 - Homo sapiens epididymis secretory sperm binding protein Li 75p (HEL-S-75p) mRNA, complete cds.
AB463692 - Synthetic construct DNA, clone: pF1KB7184, Homo sapiens GPX5 gene for glutathione peroxidase 5, without stop codon, in Flexi system.
BC111375 - Synthetic construct Homo sapiens clone IMAGE:40080648, MGC:133436 GPX5 protein (GPX5) mRNA, encodes complete protein.
AK093099 - Homo sapiens cDNA FLJ35780 fis, clone TESTI2005391, highly similar to Homo sapiens glutathione peroxidase 5 (epididymal androgen-related protein) (GPX5), transcript variant 2, mRNA.
JD117967 - Sequence 98991 from Patent EP1572962.
JD109761 - Sequence 90785 from Patent EP1572962.
JD438565 - Sequence 419589 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  BioCyc Knowledge Library
DETOX1-PWY-1 - reactive oxygen species degradation

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000412168.1, ENST00000412168.2, ENST00000412168.3, ENST00000412168.4, ENST00000412168.5, ENST00000412168.6, GPX5 , hCG_22448 , HEL-S-75p , NM_001509, uc319iew.1, uc319iew.2, V9HWN8, V9HWN8_HUMAN
UCSC ID: ENST00000412168.7_4
RefSeq Accession: NM_001509.3

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.