Human Gene GRAMD1C (ENST00000358160.9_5) from GENCODE V47lift37
  Description: GRAM domain containing 1C, transcript variant 1 (from RefSeq NM_017577.5)
Gencode Transcript: ENST00000358160.9_5
Gencode Gene: ENSG00000178075.20_11
Transcript (Including UTRs)
   Position: hg19 chr3:113,557,635-113,666,021 Size: 108,387 Total Exon Count: 18 Strand: +
Coding Region
   Position: hg19 chr3:113,557,757-113,664,325 Size: 106,569 Coding Exon Count: 18 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr3:113,557,635-113,666,021)mRNA (may differ from genome)Protein (662 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsHGNC
MGIPubMedUniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: GRM1C_HUMAN
DESCRIPTION: RecName: Full=GRAM domain-containing protein 1C;
SUBCELLULAR LOCATION: Membrane; Single-pass membrane protein (Potential).
SIMILARITY: Contains 1 GRAM domain.
SEQUENCE CAUTION: Sequence=AAH28972.1; Type=Erroneous initiation;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 8.86 RPKM in Testis
Total median expression: 123.06 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -63.60122-0.521 Picture PostScript Text
3' UTR -396.801696-0.234 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR004182 - GRAM

Pfam Domains:
PF02893 - GRAM domain
PF16016 - VAD1 Analog of StAR-related lipid transfer domain

ModBase Predicted Comparative 3D Structure on Q8IYS0
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGDEnsembl   
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding

Cellular Component:
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  AK097783 - Homo sapiens cDNA FLJ40464 fis, clone TESTI2042264.
BC035040 - Homo sapiens GRAM domain containing 1C, mRNA (cDNA clone MGC:34039 IMAGE:4829130), complete cds.
AK293884 - Homo sapiens cDNA FLJ57959 complete cds.
AK292846 - Homo sapiens cDNA FLJ76970 complete cds, highly similar to Homo sapiens GRAM domain containing 1C, mRNA.
KJ901066 - Synthetic construct Homo sapiens clone ccsbBroadEn_10460 GRAMD1C gene, encodes complete protein.
AK093181 - Homo sapiens cDNA FLJ35862 fis, clone TESTI2007346.
AX747974 - Sequence 1499 from Patent EP1308459.
AK304142 - Homo sapiens cDNA FLJ58720 complete cds.
AY358725 - Homo sapiens clone DNA105680 ENLS2543 (UNQ2543) mRNA, complete cds.
AK292964 - Homo sapiens cDNA FLJ78240 complete cds.
BC028972 - Homo sapiens GRAM domain containing 1C, mRNA (cDNA clone IMAGE:5000874), complete cds.
AL133661 - Homo sapiens mRNA; cDNA DKFZp434C0328 (from clone DKFZp434C0328).
CU688582 - Synthetic construct Homo sapiens gateway clone IMAGE:100018906 5' read GRAMD1C mRNA.
KJ904775 - Synthetic construct Homo sapiens clone ccsbBroadEn_14169 GRAMD1C gene, encodes complete protein.
BX648633 - Homo sapiens mRNA; cDNA DKFZp686K06117 (from clone DKFZp686K06117).
BX537661 - Homo sapiens mRNA; cDNA DKFZp686N2398 (from clone DKFZp686N2398).
JD240155 - Sequence 221179 from Patent EP1572962.
JD541731 - Sequence 522755 from Patent EP1572962.
JD097588 - Sequence 78612 from Patent EP1572962.
JD250638 - Sequence 231662 from Patent EP1572962.
JD303546 - Sequence 284570 from Patent EP1572962.
JD493053 - Sequence 474077 from Patent EP1572962.
JD552653 - Sequence 533677 from Patent EP1572962.
JD237406 - Sequence 218430 from Patent EP1572962.
JD498383 - Sequence 479407 from Patent EP1572962.
JD536768 - Sequence 517792 from Patent EP1572962.
JD514652 - Sequence 495676 from Patent EP1572962.
JD375527 - Sequence 356551 from Patent EP1572962.
JD162992 - Sequence 144016 from Patent EP1572962.
JD362895 - Sequence 343919 from Patent EP1572962.
JD369489 - Sequence 350513 from Patent EP1572962.
JD288712 - Sequence 269736 from Patent EP1572962.
JD300246 - Sequence 281270 from Patent EP1572962.
JD202649 - Sequence 183673 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: A8K9Y1, A8KA99, ASTRC_HUMAN, ENST00000358160.1, ENST00000358160.2, ENST00000358160.3, ENST00000358160.4, ENST00000358160.5, ENST00000358160.6, ENST00000358160.7, ENST00000358160.8, NM_017577, Q6AW94, Q6UWN1, Q8IYS0, Q8N6S0, Q9UF46, uc318akn.1, uc318akn.2, UNQ2543/PRO6095
UCSC ID: ENST00000358160.9_5
RefSeq Accession: NM_017577.5
Protein: Q8IYS0 (aka GRM1C_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.