ID:GRHL3_HUMAN DESCRIPTION: RecName: Full=Grainyhead-like protein 3 homolog; AltName: Full=Sister of mammalian grainyhead; AltName: Full=Transcription factor CP2-like 4; FUNCTION: May function as a transcription factor. SUBUNIT: Homodimer, also forms heterodimers with GRHL1 and GRHL2. SUBCELLULAR LOCATION: Nucleus. TISSUE SPECIFICITY: Expressed in brain, colon, pancreas, placenta and kidney. Isoform 1 is expressed in lung and tonsil. Isoform 2 is prostate-specific. SIMILARITY: Belongs to the grh/CP2 family. Grainyhead subfamily.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q8TE85
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding GO:0003677 DNA binding GO:0005515 protein binding GO:0031490 chromatin DNA binding GO:0043565 sequence-specific DNA binding
Biological Process: GO:0001736 establishment of planar polarity GO:0001843 neural tube closure GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006366 transcription from RNA polymerase II promoter GO:0007389 pattern specification process GO:0007398 ectoderm development GO:0007417 central nervous system development GO:0008544 epidermis development GO:0010628 positive regulation of gene expression GO:0032956 regulation of actin cytoskeleton organization GO:0042060 wound healing GO:0043547 positive regulation of GTPase activity GO:0045893 positive regulation of transcription, DNA-templated GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:0061029 eyelid development in camera-type eye GO:0061436 establishment of skin barrier GO:0090103 cochlea morphogenesis GO:0090179 planar cell polarity pathway involved in neural tube closure
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
