ID:NMDZ1_HUMAN DESCRIPTION: RecName: Full=Glutamate [NMDA] receptor subunit zeta-1; AltName: Full=N-methyl-D-aspartate receptor subunit NR1; Short=NMD-R1; Flags: Precursor; FUNCTION: NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. This protein plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. It mediates neuronal functions in glutamate neurotransmission. Is involved in the cell surface targeting of NMDA receptors (By similarity). SUBUNIT: Forms heteromeric channel of a zeta subunit (GRIN1), a epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D) and a third subunit (GRIN3A or GRIN3B); disulfide-linked. Found in a complex with GRIN2A or GRIN2B, GRIN3A or GRIN3B and PPP2CB. Interacts with DLG4 and MPDZ (By similarity). Interacts with LRFN1 and LRFN2 (By similarity). Interacts with MYZAP. SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein (By similarity). Cell junction, synapse, postsynaptic cell membrane (By similarity). Cell junction, synapse, postsynaptic cell membrane, postsynaptic density (By similarity). Note=Enriched in postsynaptic plasma membrane and postsynaptic densities (By similarity). PTM: NMDA is probably regulated by C-terminal phosphorylation of an isoform of NR1 by PKC. Dephosphorylated on Ser-897 probably by protein phosphatase 2A (PPP2CB). Its phosphorylated state is influenced by the formation of the NMDAR-PPP2CB complex and the NMDAR channel activity (By similarity). DISEASE: Defects in GRIN1 are the cause of mental retardation autosomal dominant type 8 (MRD8) [MIM:614254]. Mental retardation is characterized by significantly below average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. SIMILARITY: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. NR1/GRIN1 subfamily. WEB RESOURCE: Name=Wikipedia; Note=NMDA receptor entry; URL="http://en.wikipedia.org/wiki/NMDA_receptor";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q05586
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0000165 MAPK cascade GO:0001661 conditioned taste aversion GO:0001964 startle response GO:0001967 suckling behavior GO:0001975 response to amphetamine GO:0006811 ion transport GO:0006812 cation transport GO:0006816 calcium ion transport GO:0006874 cellular calcium ion homeostasis GO:0007420 brain development GO:0007585 respiratory gaseous exchange GO:0007611 learning or memory GO:0007612 learning GO:0007613 memory GO:0007616 long-term memory GO:0008306 associative learning GO:0008344 adult locomotory behavior GO:0008355 olfactory learning GO:0008542 visual learning GO:0010524 positive regulation of calcium ion transport into cytosol GO:0010646 regulation of cell communication GO:0018964 propylene metabolic process GO:0019233 sensory perception of pain GO:0019722 calcium-mediated signaling GO:0021586 pons maturation GO:0021987 cerebral cortex development GO:0035176 social behavior GO:0035235 ionotropic glutamate receptor signaling pathway GO:0035249 synaptic transmission, glutamatergic GO:0042391 regulation of membrane potential GO:0043065 positive regulation of apoptotic process GO:0043278 response to morphine GO:0043523 regulation of neuron apoptotic process GO:0043524 negative regulation of neuron apoptotic process GO:0043576 regulation of respiratory gaseous exchange GO:0045471 response to ethanol GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:0048013 ephrin receptor signaling pathway GO:0048167 regulation of synaptic plasticity GO:0048168 regulation of neuronal synaptic plasticity GO:0048169 regulation of long-term neuronal synaptic plasticity GO:0048814 regulation of dendrite morphogenesis GO:0050770 regulation of axonogenesis GO:0050905 neuromuscular process GO:0051290 protein heterotetramerization GO:0051963 regulation of synapse assembly GO:0055074 calcium ion homeostasis GO:0060079 excitatory postsynaptic potential GO:0060134 prepulse inhibition GO:0060179 male mating behavior GO:0097553 calcium ion transmembrane import into cytosol GO:0098976 excitatory chemical synaptic transmission GO:1903428 positive regulation of reactive oxygen species biosynthetic process GO:1903539 protein localization to postsynaptic membrane GO:1905429 response to glycine GO:2000463 positive regulation of excitatory postsynaptic potential GO:2001056 positive regulation of cysteine-type endopeptidase activity GO:1904646 cellular response to beta-amyloid
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
