ID:GRIP1_HUMAN DESCRIPTION: RecName: Full=Glutamate receptor-interacting protein 1; Short=GRIP-1; FUNCTION: May play a role as a localized scaffold for the assembly of a multiprotein signaling complex and as mediator of the trafficking of its binding partners at specific subcellular location in neurons. SUBUNIT: Interacts with EPHA7, EPHB2, KIF5A, KIF5B, KIF5C, GRIA2, GRIA3, GRIPAP1/GRASP1, PPFIA1, PPFIA4, FRAS1, PLCD4, PTPRF and liprins-alpha. Can form homomultimers or heteromultimers with GRIP2. Forms a ternary complex with GRIA2 and CSPG4 (By similarity). Interacts with ATAD1 in an ATP-dependent manner. ATAD1-catalyzed ATP hydrolysis disrupts binding to ATAD1 and to GRIA2 and leads to AMPAR complex disassembly (By similarity). Interacts with EFNB1, EFNB3 and the C-terminal tail of PRLHR. Interacts with SLC30A9 (By similarity). SUBCELLULAR LOCATION: Cytoplasmic vesicle. Endoplasmic reticulum. Cell junction, synapse, postsynaptic cell membrane (By similarity). Note=Cytoplasmic and membrane-associated with vesicles, peri-Golgi complexes and endoplasmic reticulum. Enriched in postsynaptic plasma membrane and postsynaptic densities (By similarity). DOMAIN: PDZ 6 mediates interaction with the PDZ recognition motif of EFNB1 and EPHB2 and with the C-terminus of PPFIA1 and PPFIA4. PDZ 4 and PDZ 5 mediate interaction with the C-terminus of GRIA2 and GRIA3. PDZ 4, PDZ 5 and PDZ 6 mediate homomultimers. PDZ 7 mediates interaction with PDZ domain of GRASP1. PDZ 7 domain binds CSPG4. PDZ 6 mediates interaction with the C-terminus of liprins- alpha. PDZ 1, PDZ 2 and PDZ 3 mediate interaction with the PDZ- binding motif of FRAS1 (By similarity). PDZ 4 and PDZ 5 mediate interaction with PRLHR. SIMILARITY: Contains 7 PDZ (DHR) domains.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9Y3R0
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
AK295565 - Homo sapiens cDNA FLJ59282 partial cds, highly similar to Glutamate receptor-interacting protein 1. AJ133439 - Homo sapiens mRNA for GRIP1 protein. KJ898488 - Synthetic construct Homo sapiens clone ccsbBroadEn_07882 GRIP1 gene, encodes complete protein. BC115393 - Homo sapiens glutamate receptor interacting protein 1, mRNA (cDNA clone MGC:134841 IMAGE:40053971), complete cds. BC115394 - Homo sapiens glutamate receptor interacting protein 1, mRNA (cDNA clone MGC:134842 IMAGE:40053972), complete cds. AK095519 - Homo sapiens cDNA FLJ38200 fis, clone FCBBF1000377, highly similar to Homo sapiens mRNA for GRIP1 protein. AK307576 - Homo sapiens cDNA, FLJ97524. BC029871 - Homo sapiens, clone IMAGE:5169851, mRNA. JD511326 - Sequence 492350 from Patent EP1572962. JD264934 - Sequence 245958 from Patent EP1572962. JD471299 - Sequence 452323 from Patent EP1572962. JD110729 - Sequence 91753 from Patent EP1572962. JD357718 - Sequence 338742 from Patent EP1572962. JD530901 - Sequence 511925 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q9Y3R0 (Reactome details) participates in the following event(s):
R-HSA-416639 Trafficking of GluR2-containing AMPA receptors to extrasynaptic sites R-HSA-421007 Endocytosis of Ca impermeable AMPA receptors R-HSA-416985 Trafficking of GluR2-containing AMPA receptors to synapse R-HSA-416993 Trafficking of GluR2-containing AMPA receptors R-HSA-399719 Trafficking of AMPA receptors R-HSA-399721 Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112315 Transmission across Chemical Synapses R-HSA-112316 Neuronal System
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
