ID:GRK6_HUMAN DESCRIPTION: RecName: Full=G protein-coupled receptor kinase 6; EC=2.7.11.16; AltName: Full=G protein-coupled receptor kinase GRK6; FUNCTION: Specifically phosphorylates the activated forms of G protein-coupled receptors. Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their desensitization. Seems to be involved in the desensitization of D2-like dopamin receptors in striatum and chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis (By similarity). Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor: LRP6 during Wnt signaling (in vitro). CATALYTIC ACTIVITY: ATP + [G-protein-coupled receptor] = ADP + [G- protein-coupled receptor] phosphate. SUBCELLULAR LOCATION: Membrane; Lipid-anchor. TISSUE SPECIFICITY: Widely expressed. PTM: It is uncertain whether palmitoylation is on Cys-561 and/or Cys-562 and/or Cys-565. SIMILARITY: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. SIMILARITY: Contains 1 AGC-kinase C-terminal domain. SIMILARITY: Contains 1 protein kinase domain. SIMILARITY: Contains 1 RGS domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00069 - Protein kinase domain PF00615 - Regulator of G protein signaling domain PF07714 - Protein tyrosine and serine/threonine kinase PF14531 - Kinase-like
SCOP Domains: 48097 - Regulator of G-protein signaling, RGS 56112 - Protein kinase-like (PK-like)
ModBase Predicted Comparative 3D Structure on P43250
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
