ID:GRPE1_HUMAN DESCRIPTION: RecName: Full=GrpE protein homolog 1, mitochondrial; AltName: Full=HMGE; AltName: Full=Mt-GrpE#1; Flags: Precursor; FUNCTION: Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins. SUBUNIT: Probable component of the PAM complex at least composed of a mitochondrial HSP70 protein, GRPEL1 or GRPEL2, TIMM44, TIMM16/PAM16 and TIMM14/DNAJC19 (By similarity). Binds to HSP70, HSC70 and HSJ1B. SUBCELLULAR LOCATION: Mitochondrion matrix. SIMILARITY: Belongs to the GrpE family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
SCOP Domains: 51064 - Head domain of nucleotide exchange factor GrpE 58014 - Coiled-coil domain of nucleotide exchange factor GrpE
ModBase Predicted Comparative 3D Structure on Q9HAV7
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
