Human Gene GSR (ENST00000221130.11_9) from GENCODE V47lift37

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Description: glutathione-disulfide reductase, transcript variant 1 (from RefSeq NM_000637.5)
Gencode Transcript: ENST00000221130.11_9
Gencode Gene: ENSG00000104687.14_17
Transcript (Including UTRs)
Position: hg19 chr8:30,535,583-30,585,363 Size: 49,781 Total Exon Count: 13 Strand: -
Coding Region
Position: hg19 chr8:30,537,037-30,585,352 Size: 48,316 Coding Exon Count: 13

Page Index	Sequence and Links	Primers	MalaCards	CTD	Gene Alleles
RNA-Seq Expression	Microarray Expression	RNA Structure	Other Species	mRNA Descriptions	Pathways
Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr8:30,535,583-30,585,363)			mRNA (may differ from genome)		Protein (522 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	Malacards	MGI	OMIM	PubMed	UniProtKB
Wikipedia	BioGrid CRISPR DB

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

MalaCards Disease Associations


	MalaCards Gene Search: GSR Diseases sorted by gene-association score: hemolytic anemia due to glutathione reductase deficiency* (450), riboflavin deficiency (19), transitional meningioma (15), von economo's disease (15), pyridoxine deficiency (12), meningococcal infection (10), senile cataract (10), morgagni cataract (9), lymphosarcoma (8), ariboflavinosis (6), limbic encephalitis (6), nodular goiter (5), valproate embryopathy, susceptibility to (5), rasmussen encephalitis (4), asthma (2), malaria (2), amyotrophic lateral sclerosis 1 (1) * = Manually curated disease association

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D003300 Copper C074702 chromium hexavalent ion D002330 Carmustine C017947 sodium arsenite D006861 Hydrogen Peroxide D000111 Acetylcysteine D001205 Ascorbic Acid D002104 Cadmium D019256 Cadmium Chloride D005978 Glutathione more ... click here to view the complete list

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 25.11 RPKM in Colon - Transverse Total median expression: 671.62 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
3' UTR	-533.80	1454	-0.367	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	Genome Browser	Genome Browser
Gene Details	Gene Details			Gene Details	Gene Details
Gene Sorter	Gene Sorter			Gene Sorter	Gene Sorter
	RGD	Ensembl		WormBase	SGD
				Protein Sequence	Protein Sequence
				Alignment	Alignment

Descriptions from all associated GenBank mRNAs


	LP747425 - Sequence 12 from Patent WO2018009939. BC035691 - Homo sapiens, clone IMAGE:5756011, mRNA. FJ224321 - Homo sapiens epididymis luminal protein 75 (HEL-75) mRNA, complete cds. X15722 - Human mRNA for glutathione reductase (EC 1.6.4.2). AF228704 - Homo sapiens mitochondrial glutathione reductase (GRD1) mRNA, complete cds; nuclear gene for mitochondrial product. BC069244 - Homo sapiens glutathione reductase, mRNA (cDNA clone MGC:78522 IMAGE:6422426), complete cds. GQ472231 - Homo sapiens epididymis secretory sperm binding protein Li 122m (HEL-S-122m) mRNA, complete cds. AB519179 - Homo sapiens GSR mRNA for glutathion reductase delta8 alternative splicing variant, complete cds. AB519180 - Homo sapiens GSR mRNA for glutathion reductase delta9 alternative splicing varian, complete cds. AB519181 - Homo sapiens GSR mRNA for glutathion reductase delta8+9 alternative splicing variant, complete cds. MB486565 - JP 2019531699-A/12: METHODS FOR DIAGNOSING AND TREATING CANCER. DL491371 - Novel nucleic acids. DL490001 - Novel nucleic acids. JD199645 - Sequence 180669 from Patent EP1572962. JD147076 - Sequence 128100 from Patent EP1572962. JD111224 - Sequence 92248 from Patent EP1572962. JD332595 - Sequence 313619 from Patent EP1572962. JD539161 - Sequence 520185 from Patent EP1572962. LQ021088 - Sequence 31 from Patent WO2015144924. X54507 - H.sapiens mRNA for glutathione reductase (partial). CU686724 - Synthetic construct Homo sapiens gateway clone IMAGE:100023160 5' read GSR mRNA. JD210773 - Sequence 191797 from Patent EP1572962. JD424115 - Sequence 405139 from Patent EP1572962.

Biochemical and Signaling Pathways


	BioCyc Knowledge Library PWY-4081 - glutathione-peroxide redox reactions BioCarta from NCI Cancer Genome Anatomy Project h_freePathway - Free Radical Induced Apoptosis

Other Names for This Gene


	Alternate Gene Symbols: ENST00000221130.1, ENST00000221130.10, ENST00000221130.2, ENST00000221130.3, ENST00000221130.4, ENST00000221130.5, ENST00000221130.6, ENST00000221130.7, ENST00000221130.8, ENST00000221130.9, HEL-75 , HEL-S-122m , NM_000637, uc317daf.1, uc317daf.2, V9HW90, V9HW90_HUMAN UCSC ID: ENST00000221130.11_9 RefSeq Accession: NM_000637.5

Gene Model Information


	Click here for a detailed description of the fields of the table above.

Methods, Credits, and Use Restrictions


	Click here for details on how this gene model was made and data restrictions if any.