Human Gene GSR (ENST00000221130.11_9) from GENCODE V47lift37
  Description: glutathione-disulfide reductase, transcript variant 1 (from RefSeq NM_000637.5)
Gencode Transcript: ENST00000221130.11_9
Gencode Gene: ENSG00000104687.14_17
Transcript (Including UTRs)
   Position: hg19 chr8:30,535,583-30,585,363 Size: 49,781 Total Exon Count: 13 Strand: -
Coding Region
   Position: hg19 chr8:30,537,037-30,585,352 Size: 48,316 Coding Exon Count: 13 

Page IndexSequence and LinksPrimersMalaCardsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureOther SpeciesmRNA DescriptionsPathways
Other NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr8:30,535,583-30,585,363)mRNA (may differ from genome)Protein (522 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedUniProtKB
WikipediaBioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: GSR
Diseases sorted by gene-association score: hemolytic anemia due to glutathione reductase deficiency* (450), riboflavin deficiency (19), transitional meningioma (15), von economo's disease (15), pyridoxine deficiency (12), meningococcal infection (10), senile cataract (10), morgagni cataract (9), lymphosarcoma (8), ariboflavinosis (6), limbic encephalitis (6), nodular goiter (5), valproate embryopathy, susceptibility to (5), rasmussen encephalitis (4), asthma (2), malaria (2), amyotrophic lateral sclerosis 1 (1)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 25.11 RPKM in Colon - Transverse
Total median expression: 671.62 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
3' UTR -533.801454-0.367 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologGenome BrowserGenome Browser
Gene DetailsGene Details  Gene DetailsGene Details
Gene SorterGene Sorter  Gene SorterGene Sorter
 RGDEnsembl WormBaseSGD
    Protein SequenceProtein Sequence
    AlignmentAlignment

-  Descriptions from all associated GenBank mRNAs
  LP747425 - Sequence 12 from Patent WO2018009939.
BC035691 - Homo sapiens, clone IMAGE:5756011, mRNA.
FJ224321 - Homo sapiens epididymis luminal protein 75 (HEL-75) mRNA, complete cds.
X15722 - Human mRNA for glutathione reductase (EC 1.6.4.2).
AF228704 - Homo sapiens mitochondrial glutathione reductase (GRD1) mRNA, complete cds; nuclear gene for mitochondrial product.
BC069244 - Homo sapiens glutathione reductase, mRNA (cDNA clone MGC:78522 IMAGE:6422426), complete cds.
GQ472231 - Homo sapiens epididymis secretory sperm binding protein Li 122m (HEL-S-122m) mRNA, complete cds.
AB519179 - Homo sapiens GSR mRNA for glutathion reductase delta8 alternative splicing variant, complete cds.
AB519180 - Homo sapiens GSR mRNA for glutathion reductase delta9 alternative splicing varian, complete cds.
AB519181 - Homo sapiens GSR mRNA for glutathion reductase delta8+9 alternative splicing variant, complete cds.
MB486565 - JP 2019531699-A/12: METHODS FOR DIAGNOSING AND TREATING CANCER.
DL491371 - Novel nucleic acids.
DL490001 - Novel nucleic acids.
JD199645 - Sequence 180669 from Patent EP1572962.
JD147076 - Sequence 128100 from Patent EP1572962.
JD111224 - Sequence 92248 from Patent EP1572962.
JD332595 - Sequence 313619 from Patent EP1572962.
JD539161 - Sequence 520185 from Patent EP1572962.
LQ021088 - Sequence 31 from Patent WO2015144924.
X54507 - H.sapiens mRNA for glutathione reductase (partial).
CU686724 - Synthetic construct Homo sapiens gateway clone IMAGE:100023160 5' read GSR mRNA.
JD210773 - Sequence 191797 from Patent EP1572962.
JD424115 - Sequence 405139 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  BioCyc Knowledge Library
PWY-4081 - glutathione-peroxide redox reactions

BioCarta from NCI Cancer Genome Anatomy Project
h_freePathway - Free Radical Induced Apoptosis

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000221130.1, ENST00000221130.10, ENST00000221130.2, ENST00000221130.3, ENST00000221130.4, ENST00000221130.5, ENST00000221130.6, ENST00000221130.7, ENST00000221130.8, ENST00000221130.9, HEL-75 , HEL-S-122m , NM_000637, uc317daf.1, uc317daf.2, V9HW90, V9HW90_HUMAN
UCSC ID: ENST00000221130.11_9
RefSeq Accession: NM_000637.5

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.