ID:GSTA1_HUMAN DESCRIPTION: RecName: Full=Glutathione S-transferase A1; EC=2.5.1.18; AltName: Full=GST HA subunit 1; AltName: Full=GST class-alpha member 1; AltName: Full=GST-epsilon; AltName: Full=GSTA1-1; AltName: Full=GTH1; FUNCTION: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. CATALYTIC ACTIVITY: RX + glutathione = HX + R-S-glutathione. SUBUNIT: Homodimer or heterodimer of GSTA1 and GSTA2. SUBCELLULAR LOCATION: Cytoplasm. TISSUE SPECIFICITY: Liver. DOMAIN: The C-terminal domain may form a component of the hydrophobic substrate-binding site, but in contrast appears not to be directly involved in GSH binding and is not absolutely essential for catalytic activity. SIMILARITY: Belongs to the GST superfamily. Alpha family. SIMILARITY: Contains 1 GST C-terminal domain. SIMILARITY: Contains 1 GST N-terminal domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P08263
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
