Human Gene GSTM1 (ENST00000309851.10_4) from GENCODE V47lift37
  Description: glutathione S-transferase mu 1, transcript variant 1 (from RefSeq NM_000561.4)
Gencode Transcript: ENST00000309851.10_4
Gencode Gene: ENSG00000134184.13_13
Transcript (Including UTRs)
   Position: hg19 chr1:110,230,439-110,236,367 Size: 5,929 Total Exon Count: 8 Strand: +
Coding Region
   Position: hg19 chr1:110,230,496-110,235,917 Size: 5,422 Coding Exon Count: 8 

Page IndexSequence and LinksPrimersMalaCardsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureOther SpeciesmRNA DescriptionsPathways
Other NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:110,230,439-110,236,367)mRNA (may differ from genome)Protein (218 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsHGNC
MalacardsMGIOMIMPubMedUniProtKBWikipedia
BioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: GSTM1
Diseases sorted by gene-association score: lung cancer, gstm1-related* (100), lung cancer* (34), senile cataract (29), asbestosis (27), oral leukoplakia (24), larynx cancer (24), urinary bladder cancer (19), oral cancer (15), toxic encephalopathy (12), oral cavity cancer (11), alcoholic liver cirrhosis (11), pharynx cancer (11), acute leukemia (10), leukoplakia (10), mutagen sensitivity (9), central serous chorioretinopathy (9), varicocele (8), drug-induced hepatitis (8), nicotine dependence, protection against (8), esophageal cancer (8), oral submucous fibrosis (8), scabies (7), acute lymphoblastic leukemia, childhood (7), neonatal jaundice (7), isolated cleft lip (7), open-angle glaucoma (7), pneumoconiosis (7), oligospermia (7), toxic oil syndrome (6), glaucoma 1, open angle, e (6), ischemic optic neuropathy (6), arteritic anterior ischemic optic neuropathy (6), diffuse gastric cancer (5), norwegian scabies (5), endometriosis (4), basal cell carcinoma (4), nasopharyngeal carcinoma (3), aplastic anemia (3), acute lymphocytic leukemia (3), bladder cancer, somatic (2), colorectal cancer (2), substance dependence (2), lynch syndrome (2), myelodysplastic syndrome (2), stomach cancer (2), squamous cell carcinoma, head and neck (2), prostate cancer (1), prostate cancer susceptibility (1)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 33.93 RPKM in Ovary
Total median expression: 424.35 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -15.9057-0.279 Picture PostScript Text
3' UTR -154.60450-0.344 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
      
      
      
      
      

-  Descriptions from all associated GenBank mRNAs
  BC024005 - Homo sapiens glutathione S-transferase mu 1, mRNA (cDNA clone MGC:26563 IMAGE:4823313), complete cds.
BC095463 - Homo sapiens cDNA clone IMAGE:30563420, containing frame-shift errors.
X08020 - Human mRNA for glutathione S-transferase subunit 4 (EC 2.5.1.18).
J03817 - Human glutathione transferase M1B (GST1) mRNA, complete cds.
BC036805 - Homo sapiens glutathione S-transferase M1, mRNA (cDNA clone IMAGE:5726483).
GQ129273 - Synthetic construct Homo sapiens clone HAIB:100068668; DKFZo004C0636 glutathione S-transferase M1 protein (GSTM1) gene, partial cds.
GQ129274 - Synthetic construct Homo sapiens clone HAIB:100068571; DKFZo008C0635 glutathione S-transferase M1 protein (GSTM1) gene, complete cds.
AB590610 - Synthetic construct DNA, clone: pFN21AE1714, Homo sapiens GSTM1 gene for glutathione S-transferase mu 1, without stop codon, in Flexi system.
KJ534856 - Homo sapiens clone GSTM1_iso-D_fetal-F04 glutathione S-transferase mu 1 isoform D (GSTM1) mRNA, partial cds, alternatively spliced.
KJ534857 - Homo sapiens clone GSTM1_iso-B_fetal-F08 glutathione S-transferase mu 1 isoform B (GSTM1) mRNA, partial cds, alternatively spliced.
KJ534858 - Homo sapiens clone GSTM1_iso-C_fetal-F11 glutathione S-transferase mu 1 isoform C (GSTM1) mRNA, partial cds, alternatively spliced.
KJ534998 - Homo sapiens clone GSTM1_iso-E_fetal-F07 glutathione S-transferase mu 1 isoform E (GSTM1) mRNA, complete cds, alternatively spliced.
KJ535021 - Homo sapiens clone GSTM1_iso-A_fetal-F09 glutathione S-transferase mu 1 isoform A (GSTM1) mRNA, complete cds, alternatively spliced.
AY510272 - Homo sapiens glutathione S-transferase M1 mRNA, complete cds.
AY532926 - Homo sapiens chromosome 1 glutathione-S-transferase M1 mRNA, complete cds.
AY532927 - Homo sapiens chromosome 1 glutathione S-transferase M1 transcript variant 2 mRNA, complete cds.
CR541868 - Homo sapiens full open reading frame cDNA clone RZPDo834H1032D for gene GSTM1, glutathione S-transferase M1; complete cds, incl. stopcodon.
CU692840 - Synthetic construct Homo sapiens gateway clone IMAGE:100020183 5' read GSTM1 mRNA.
HQ448375 - Synthetic construct Homo sapiens clone IMAGE:100071799; CCSB001300_01 glutathione S-transferase M1 (GSTM1) gene, encodes complete protein.
KJ891308 - Synthetic construct Homo sapiens clone ccsbBroadEn_00702 GSTM1 gene, encodes complete protein.
JD419144 - Sequence 400168 from Patent EP1572962.
JD095033 - Sequence 76057 from Patent EP1572962.
JD251853 - Sequence 232877 from Patent EP1572962.
JD345790 - Sequence 326814 from Patent EP1572962.
JD452833 - Sequence 433857 from Patent EP1572962.
JD414392 - Sequence 395416 from Patent EP1572962.
JD194050 - Sequence 175074 from Patent EP1572962.
JD370037 - Sequence 351061 from Patent EP1572962.
JD553505 - Sequence 534529 from Patent EP1572962.
JD563271 - Sequence 544295 from Patent EP1572962.
JD380531 - Sequence 361555 from Patent EP1572962.
JD392325 - Sequence 373349 from Patent EP1572962.
JD377881 - Sequence 358905 from Patent EP1572962.
JD353818 - Sequence 334842 from Patent EP1572962.
JD058572 - Sequence 39596 from Patent EP1572962.
JD045513 - Sequence 26537 from Patent EP1572962.
JD537152 - Sequence 518176 from Patent EP1572962.
JD240165 - Sequence 221189 from Patent EP1572962.
JD487843 - Sequence 468867 from Patent EP1572962.
JD161280 - Sequence 142304 from Patent EP1572962.
JD068279 - Sequence 49303 from Patent EP1572962.
JD438097 - Sequence 419121 from Patent EP1572962.
JD174754 - Sequence 155778 from Patent EP1572962.
JD255026 - Sequence 236050 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  BioCyc Knowledge Library
PWY-4061 - glutathione-mediated detoxification I

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000309851.1, ENST00000309851.2, ENST00000309851.3, ENST00000309851.4, ENST00000309851.5, ENST00000309851.6, ENST00000309851.7, ENST00000309851.8, ENST00000309851.9, GSTM1 , NM_000561, uc317opm.1, uc317opm.2, X5DR03, X5DR03_HUMAN
UCSC ID: ENST00000309851.10_4
RefSeq Accession: NM_000561.4

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.