Human Gene GSTP1 (ENST00000398606.10_6) from GENCODE V47lift37
  Description: glutathione S-transferase pi 1 (from RefSeq NM_000852.4)
Gencode Transcript: ENST00000398606.10_6
Gencode Gene: ENSG00000084207.18_13
Transcript (Including UTRs)
   Position: hg19 chr11:67,351,283-67,354,124 Size: 2,842 Total Exon Count: 7 Strand: +
Coding Region
   Position: hg19 chr11:67,351,315-67,354,048 Size: 2,734 Coding Exon Count: 7 

Page IndexSequence and LinksPrimersMalaCardsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureOther SpeciesmRNA DescriptionsPathways
Other NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr11:67,351,283-67,354,124)mRNA (may differ from genome)Protein (210 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedUniProtKB
WikipediaBioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: GSTP1
Diseases sorted by gene-association score: oral mucosa leukoplakia (15), prostate cancer (15), squamous cell carcinoma (13), prostate adenocarcinoma (8), larynx cancer (8), hepatocellular adenoma (7), adamantinoma of long bones (7), asbestosis (6), diffuse gastric cancer (6), hellp syndrome (6), lung cancer (6), ovarian cyst (6), progressive bulbar palsy (5), bladder cancer, somatic (5), barrett esophagus/esophageal adenocarcinoma (5), esophageal cancer (4), asthma (4), colorectal cancer (3), stomach cancer (3), kidney cancer (3), hepatocellular carcinoma (3), urinary bladder cancer (2), ovarian cancer, somatic (2), breast cancer (2), testicular germ cell tumor (2), squamous cell carcinoma, head and neck (2), male reproductive organ cancer (2), lynch syndrome (1), reproductive organ cancer (1), gastric cancer, somatic (1), colonic benign neoplasm (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 968.47 RPKM in Esophagus - Mucosa
Total median expression: 10189.22 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -4.5032-0.141 Picture PostScript Text
3' UTR -22.6076-0.297 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologGenome BrowserNo ortholog
Gene DetailsGene Details  Gene Details 
Gene SorterGene Sorter  Gene Sorter 
 RGDEnsembl WormBase 
    Protein Sequence 
    Alignment 

-  Descriptions from all associated GenBank mRNAs
  D28456 - Homo sapiens mRNA for glutathione S-transferase Pi, 5'UTR region.
AY887902 - Homo sapiens mutant GSTP1 (GSTP1) mRNA, complete cds.
BC010915 - Homo sapiens glutathione S-transferase pi 1, mRNA (cDNA clone MGC:13474 IMAGE:3960700), complete cds.
EU794620 - Homo sapiens epididymis secretory protein Li 22 (HEL-S-22) mRNA, complete cds.
BC044846 - Homo sapiens glutathione S-transferase pi 1, mRNA (cDNA clone IMAGE:5162861), with apparent retained intron.
X15480 - Human mRNA for anionic glutathione-S-transferase (GST-pi-1).
U62589 - Human glutathione S-transferase P1c (GSTp1c) mRNA, complete cds.
U30897 - Human glutathione S-transferase (P1b) mRNA, complete cds.
AB527935 - Synthetic construct DNA, clone: pF1KB0973, Homo sapiens GSTP1 gene for glutathione S-transferase pi 1, without stop codon, in Flexi system.
CR450361 - Homo sapiens full open reading frame cDNA clone RZPDo834C083D for gene GSTP1, glutathione S-transferase pi; complete cds; without stopcodon.
BT019949 - Homo sapiens glutathione S-transferase pi mRNA, complete cds.
BT019950 - Homo sapiens glutathione S-transferase pi mRNA, complete cds.
DQ892738 - Synthetic construct clone IMAGE:100005368; FLH189249.01X; RZPDo839D0274D glutathione S-transferase pi (GSTP1) gene, encodes complete protein.
DQ895985 - Synthetic construct Homo sapiens clone IMAGE:100010445; FLH189245.01L; RZPDo839D0264D glutathione S-transferase pi (GSTP1) gene, encodes complete protein.
KJ896941 - Synthetic construct Homo sapiens clone ccsbBroadEn_06335 GSTP1 gene, encodes complete protein.
AY579414 - Homo sapiens glutathione S-transferase pi-like mRNA, partial sequence.
M69113 - Human fatty acid ethyl ester synthase-III mRNA sequence.
X06547 - Human mRNA for class Pi glutathione S-transferase (GST-Pi; E.C.2.5.1.18).
LF205523 - JP 2014500723-A/13026: Polycomb-Associated Non-Coding RNAs.
GQ141553 - Homo sapiens isolate PV-1A glutathione S-transferase pi (GSTP1) mRNA, partial cds.
GQ141554 - Homo sapiens isolate PF-1A glutathione S-transferase pi (GSTP1) mRNA, partial cds.
LF321463 - JP 2014500723-A/128966: Polycomb-Associated Non-Coding RNAs.
LF321462 - JP 2014500723-A/128965: Polycomb-Associated Non-Coding RNAs.
MA557040 - JP 2018138019-A/128966: Polycomb-Associated Non-Coding RNAs.
MA557039 - JP 2018138019-A/128965: Polycomb-Associated Non-Coding RNAs.
MA441100 - JP 2018138019-A/13026: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  BioCyc Knowledge Library
PWY-4061 - glutathione-mediated detoxification I
PWY-7112 - 4-hydroxy-2-nonenal detoxification

BioCarta from NCI Cancer Genome Anatomy Project
h_mrpPathway - Multi-Drug Resistance Factors

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000398606.1, ENST00000398606.2, ENST00000398606.3, ENST00000398606.4, ENST00000398606.5, ENST00000398606.6, ENST00000398606.7, ENST00000398606.8, ENST00000398606.9, GSTP1 , hCG_21055 , HEL-S-22 , NM_000852, uc318zvl.1, uc318zvl.2, V9HWE9, V9HWE9_HUMAN
UCSC ID: ENST00000398606.10_6
RefSeq Accession: NM_000852.4

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.